颈康酊质量标准的建立
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摘要
目的:建立颈康酊质量标准。方法:采用TLC法对颈康酊中的三七、苏木、路路通药材进行定性鉴别,用HPLC法对三七中的人参皂苷Rbl进行含量测定研究。结果:TLC法可鉴定出制剂中的三七、苏木、路路通;人参皂苷Rbl在0. 856～8. 560μg范围内线性关系良好(r=0. 999 9),平均回收率为100. 30%,RSD为2. 70%(n=6)。结论:本法准确、简便、重复性好,可用于颈康酊的质量控制。
Objective: To establish the quality standard for Jingkang tincture. Methods: An TLC was adopted to identify Panax notoginseng( Burkill) F. H. Chen ex C. H.,Caesalpinia sappan L. and Fructus Liquidambaris in Jingkang tincture.HPLC was adopted to determine the content of ginsnoside Rb1 in Jingkang tincture. Results: Panax notoginseng( Burkill) F. H.Chen ex C. H.,Caesalpinia sappan L. and Fructus Liquidambaris could be identified by TLC. The linear range of ginsenoside Rb1 was 0. 856-8. 560 ! g( r = 0. 999 9),and the average recovery was 100. 30% with the RSD of 2. 70%( n = 6). Conclusion: The method is simple,accurate and reproducible,which can be used for the quality control of Jingkang tincture.
Objective: To establish the quality standard for Jingkang tincture. Methods: An TLC was adopted to identify Panax notoginseng( Burkill) F. H. Chen ex C. H.,Caesalpinia sappan L. and Fructus Liquidambaris in Jingkang tincture.HPLC was adopted to determine the content of ginsnoside Rb1 in Jingkang tincture. Results: Panax notoginseng( Burkill) F. H.Chen ex C. H.,Caesalpinia sappan L. and Fructus Liquidambaris could be identified by TLC. The linear range of ginsenoside Rb1 was 0. 856-8. 560 ! g( r = 0. 999 9),and the average recovery was 100. 30% with the RSD of 2. 70%( n = 6). Conclusion: The method is simple,accurate and reproducible,which can be used for the quality control of Jingkang tincture.
引文
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6孙肖琛,王芳,孟楣,等.UPLC-ELSD法测定芪白平肺胶囊中人参皂苷Rb1的含量[J].安徽医药,2015,19(7):1268-1271
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8曹泽峰,高松,孙磊,等.橘皮竹茹汤中人参皂苷Rb1的HPLC含量测定方法[J].国际药学研究杂志,2017,44(6):647-650
2朱山寅.路路通及其混伪品悬铃木果序的鉴别[J].中药材,2000,(4):198-199
3中国药典[S].2015年版.一部.11-12
4程道海,王捷,陆华,等.HPLC法同时测定舒血灵胶囊中三七皂苷R1、人参皂苷Rg1及人参皂苷Rb1的含量[J].中国药师,2015,18(11):1978-1980
5杨辉,劳广耀,唐德智.HPLC法测定复方黄根颗粒中人参皂苷Rg1、人参皂苷Rb1和三七皂苷R1含量[J].中国药师,2015,18(1):55-57
6孙肖琛,王芳,孟楣,等.UPLC-ELSD法测定芪白平肺胶囊中人参皂苷Rb1的含量[J].安徽医药,2015,19(7):1268-1271
7张洁,白娟,李成网.HPLC法测定祛白酊中人参皂苷Rb1的含量[J].亚太传统医药,2009,5(4):25-26
8曹泽峰,高松,孙磊,等.橘皮竹茹汤中人参皂苷Rb1的HPLC含量测定方法[J].国际药学研究杂志,2017,44(6):647-650