中药资源产业化过程循环利用适宜技术体系创建及其推广应用
|
摘要
针对我国中药资源生产与深加工全产业链资源利用效率低下、资源消耗和浪费严重、生态环境压力不断加剧等重大经济、社会和生态问题,围绕中药资源循环利用共性关键技术进行集成创新,为推动我国中药资源全产业链的提质增效、资源节约和绿色发展做出引领性贡献。创新性地提出并构建了中药资源循环利用理论体系;系统创建适宜于中药废弃物及副产物的生物转化、化学转化和物理转化三套循环利用适宜技术;示范性地将非药用部位、废弃物及副产物转化为新医药及健康产品、新资源药材、纤维素酶、低聚糖、生物乙醇、生物炭及炭基复合肥等资源性产品,致力于推广"源于农田归于农田,提质增效绿色发展"的循环经济理念。研究成果服务于我国中药资源全产业链的提质增效与绿色发展。
Considering the major economic,social and ecological low efficiency of resource utilization,overconsumption and waste of resources,and the increasing pressure on ecological environment during the production and deep processing of Chinese Medicinal Materials( CMM) resources,the authors have developed the common key technologies of circulating utilization of resources and contributed the improvement of quality and efficiency,resource conservation and green development of the whole industry chain of CMM. The theoretical foundation of recycling utilization of CMM resources is put forward and constructed innovatively. Three sets of recycling technology systems suitable for biotransformation,chemical transformation and physical transformation of CMM wastes and by-products were established. As practices,some non-medicinal parts,wastes and by-products were innovatively transformed into new pharmaceutical and health products,new resource medicinal materials,cellulase,oligosaccharides,bioethanol,biochar and carbon-based compound fertilizer,etc. The efforts aim to realize the idea of "returning farmland to farmland,and improving quality,efficiency and green development"The application of recycling technology systems have applied for the improvement of quality and green development in the process of industrialization of CMM resources.
Considering the major economic,social and ecological low efficiency of resource utilization,overconsumption and waste of resources,and the increasing pressure on ecological environment during the production and deep processing of Chinese Medicinal Materials( CMM) resources,the authors have developed the common key technologies of circulating utilization of resources and contributed the improvement of quality and efficiency,resource conservation and green development of the whole industry chain of CMM. The theoretical foundation of recycling utilization of CMM resources is put forward and constructed innovatively. Three sets of recycling technology systems suitable for biotransformation,chemical transformation and physical transformation of CMM wastes and by-products were established. As practices,some non-medicinal parts,wastes and by-products were innovatively transformed into new pharmaceutical and health products,new resource medicinal materials,cellulase,oligosaccharides,bioethanol,biochar and carbon-based compound fertilizer,etc. The efforts aim to realize the idea of "returning farmland to farmland,and improving quality,efficiency and green development"The application of recycling technology systems have applied for the improvement of quality and green development in the process of industrialization of CMM resources.
引文
[1]段金廒,张伯礼,宿树兰,等.基于循环经济理论的中药资源循环利用策略与模式探讨[J].中草药,2015,46(12):1715-1722.
[2]段金廒,宿树兰,郭盛,等.中药资源化学研究与中药资源循环利用途径及目标任务[J].中国中药杂志,2015,40(13):69-75.
[3]段金廒,宿树兰,郭盛,等.中药资源产业化过程废弃物的产生及其利用策略与资源化模式[J].中草药,2013,44(20):2787-2797.
[4]段金廒,宿树兰,郭盛,等.中药废弃物的转化增效资源化模式及其研究与实践[J].中国中药杂志,2013,38(24):3991-3996.
[5]段金廒.中药资源化学---理论基础与资源循环利用[M].北京:科学出版社,2015.
[6]朱华旭,段金廒,郭立玮,等.基于膜科学技术的中药废弃物资源化原理及其应用实践[J].中国中药杂志,2014,39(9):1728-1732.
[7]朱华旭,唐志书,段金廒,等.基于资源循环经济的中药脉络宁注射液废弃物资源化循环利用中的共性关键问题[J].中国现代中药,2017,19(12):1672-1676,1687.
[8]刘双双,刘丽芳,朱华旭,等.超滤膜技术用于脉络宁注射液废弃物中多糖分离及其活性筛选研究[J].中草药,2016,47(13):2288-2293.
[9]刘双双,刘丽芳,朱华旭,等.酶解等4种方法用于中药废弃物资源化研究初探(Ⅰ)-以脉络宁注射液生产中石斛药渣的多糖资源化研究为例[J].中国实验方剂学杂志,2016,22(22):34-40.
[10]戴新新,沈飞,宿树兰,等.丹参药渣中丹参酮类化学成分的提取富集研究及其利用途径分析[J].中国现代中药,2016,18(12):1578-1582.
[11]戴新新,沈飞,宿树兰,等.酸碱预处理后酶解提升丹参药渣中丹参酮类成分的提取效率研究[J].中国中药杂志,2016,41(18):3355-3360.
[12]宿树兰,段金廒,赵步长,等.一种应用糖化预处理方法从丹参药渣中提取制备丹参酮类成分的方法:CN201510007766.7[P].2015-01-07.
[13]WENG Z B,GUO S,QIAN D W,et al.Sophora flavescens Seed as a promising high potential by-product:Phytochemical characterization and bioactivity evaluation[J].Ind Crop Prod,2017,109:19-26.
[14]季浩,滕丰琳,窦长清.一种甘草次酸的提纯方法:CN201510234378.2[P].2015-05-08.
[15]季浩,阚建伟,徐娟.一种复合甜味剂及其制备方法:CN201510220799.X[P].2015-05-04.
[16]郭盛,段金廒,鲁学军,等.中药固体废弃物的热解炭化利用策略与研究实践[J].中国现代中药,2017,19(12):1665-1671.
[17]段金廒,鲁学军,钱大玮,等.利用中药材及中药生产过程废弃物制取生物炭的装置及其方法:CN201510644189.2[P].2015-09-30.
[18]段金廒,鲁学军,钱大玮,等.一种连续式无氧热解炭化机:CN 201520774529.9[P].2015-09-30.
[19]江曙,刘培,段金廒,等.基于微生物转化的中药废弃物利用价值提升策略探讨[J].世界科学技术-中医药现代化,2014,16(6):1210-1216.
[20]段金廒,曾飞,张森,等.一种耐受甘草药渣的纤维素酶产生菌及应用于甘草药渣产纤维素酶的方法:CN201710560473.0[P].2017-07-11.
[21]曾飞,张森,钱大玮,等.甘草药渣降解菌的筛选及其产酶工艺研究[J].生物技术通报,2017,33(12):125-131.
[22]马新飞,张森,段金廒,等.一种高产细菌多糖的菌株及其发酵中药废弃物制备多糖的方法:CN 201710077738.1[P].2017-02-14.
[23]张森,段金廒,陶伟伟,等.一种中间苍白杆菌胞外多糖及其在土壤改良方面的应用:CN 201710077783.7[P].2017-02-14.
[24]李会伟,段金廒,刘培,等.莲藕中白桦脂酸的微生物转化及其产物的抗肿瘤活性研究[J].南京中医药大学学报,2017,33(2):144-149.
[25]张森,段金廒,朱振华,等.一种解淀粉芽孢杆菌及在非水相中制备琥珀酰芒柄花苷的方法:ZL 2016 1 0719089.6[P].2016-08-24.
[26]张森,段金廒,刘培,等.一种高糖基转移活性解淀粉芽孢杆菌在非水相中生物合成红景天苷的应用:CN201811363071.2[P].2018-11-16.
[27]张森,段金廒,赵明,等.一种地衣芽孢杆菌及高效制备3'-琥珀酰木犀草苷及4'-琥珀酰木犀草苷的方法:CN201810747299.5[P].2018-07-09.
[28]ZHAO Y X,WANG J J,ZHANG L,et al.Bioactive luteoloside produced by Myroides odoratimimus,solvent-tolerant bacterium form the rhizosphere of Lonicera japonica[J].Nat Prod Res,2018,doi:10.1080/14786419.2018.1481838.
[29]ZHANG S,LI D D,ZENG F,et al.Efficient biosynthesis,analysis,solubility and anti-bacterial activities of succinylglycosylated naringenin[J].Nat Prod Res,2018,doi:10.1080/14786419.2018.1431633.
[30]段金廒,郭盛,钱大玮.一种富含纤维素类物质的中药药渣高值化综合利用的方法:CN 201510962054.0[P].2015-12-21.
[31]段金廒.中药废弃物的资源化利用[M].北京:化学工业出版社,2013.
[32]郭盛,段金廒,钱大玮,等.一种中药药渣生物质燃料颗粒及其制备方法:CN 201510746799.3[P].2015-11-05.
[33]严辉,张森,陈佩东,等.基于木塑产品开发的中药固体废弃物资源化利用研究[J].中国现代中药,2017,19(12):1677-1682.
[34]陈佩东,段金廒,严辉,等.一种用黄蜀葵秸秆制备塑木材料的方法:CN 201310494845.6[P].2013-10-21.
[35]严辉,段金廒,陈佩东,等.一种蒸爆解纤自胶结黄蜀葵纤维板的制备方法:CN 201310479642.X[P].2013-10-15.
[36]陶金华,段金廒,钱大玮,等.菊属药用植物资源化学研究进展[J].中国现代中药,2016,18(9):1212-1219,1229.
[37]TAO J H,DUAN J A,JIANG S,et al.Biotransformation and metabolic profile of buddleoside with human intestinal microflora by ultrahigh-performance liquid chromatography coupled to hybrid linear ion trap/orbitrap mass spectrometer[J].J Chromatogr B,2016,1025:7-15.
[38]TAO J H,DUAN J A,JIANG S,et al.Simultaneous determination of six short-chain fatty acids in colonic contents of colitis mice after oral administration of polysaccharides from Chrysanthemum morifolium Ramat by gas chromatography with flame ionization detector[J].J Chromatogr B,2016,1029:88-94.
[39]赵明,段金廒,张森,等.基于中药资源产业化过程副产物开发禽畜用药及饲料添加剂的策略与路径[J].中国中药杂志,2017,42(18):3628-3632.
[40]顾俊菲,宿树兰,彭珂毓,等.丹参地上部分资源价值发现与开发利用策略[J].中国现代中药,2017,19(12):1659-1664.
[41]ZENG H T,SU S L,XIANG X,et al.Comparative Analysis of the Major Chemical Constituents in Salvia miltiorrhiza Roots,Stems,Leaves and Flowers during Different Growth Periods by UPLC-TQ-MS/MS and HPLC-ELSD Methods[J].Molecules,2017,22:771.
[42]GU J F,SU S L,GUO J M,et al.The aerial parts of Salvia miltiorrhiza Bge.strengthen intestinal barrier and modulate gut microbiota imbalance in streptozocin-induced diabetic mice[J].J Funct Food,2017,36:362-374.
[43]宿树兰,段金廒,江曙,等.利用生物转化技术从丹参地上茎叶中高效制备丹参酚酸类成分的方法:CN 201510070147.2[P].2015-02-10.
[44]张贻昌,王明耿.中药产品质量过程控制的重要性[J].中成药,2012,34(8):1581-1585.
[45]LIU H B,TANG Z S,CUI C L,et al.Fouling mechanisms of the extract of traditional Chinese medicine in ultrafiltration[J].Desalination,2014,354:87-96.
[46]GUO S,DUAN J A,LI Y Q,et al.Comparison of the Bioactive Components in Two Seeds of Ziziphus Species by Different Analytical Approaches Combined with Chemometrics[J].Front Pharmacol,2017,8:609.
[47]GUO S,DUAN J A,TANG Y P,et al.Simultaneous qualitative and quantitative analysis of triterpenic acids,saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD[J].J Pharm Biomed Anal,2011,56(2):264-270.
[48]段金廒,郭盛,钱大玮.酸枣的活性部位及其制备方法与应用:ZL 2012 1 0137229.0[P].2013-11-06.
[49]唐志书,张严磊,段金廒,等.一种提取酸枣渣中可溶性与不溶性膳食纤维的制备方法:ZL 2015 1 0617096.0[P].2018-03-27.
[50]张严磊,唐志书,宋忠兴,等.一种酸枣核壳木糖及二氧化硅的制备方法:ZL 2015 1 0615309.6[P].2018-01-02.
[2]段金廒,宿树兰,郭盛,等.中药资源化学研究与中药资源循环利用途径及目标任务[J].中国中药杂志,2015,40(13):69-75.
[3]段金廒,宿树兰,郭盛,等.中药资源产业化过程废弃物的产生及其利用策略与资源化模式[J].中草药,2013,44(20):2787-2797.
[4]段金廒,宿树兰,郭盛,等.中药废弃物的转化增效资源化模式及其研究与实践[J].中国中药杂志,2013,38(24):3991-3996.
[5]段金廒.中药资源化学---理论基础与资源循环利用[M].北京:科学出版社,2015.
[6]朱华旭,段金廒,郭立玮,等.基于膜科学技术的中药废弃物资源化原理及其应用实践[J].中国中药杂志,2014,39(9):1728-1732.
[7]朱华旭,唐志书,段金廒,等.基于资源循环经济的中药脉络宁注射液废弃物资源化循环利用中的共性关键问题[J].中国现代中药,2017,19(12):1672-1676,1687.
[8]刘双双,刘丽芳,朱华旭,等.超滤膜技术用于脉络宁注射液废弃物中多糖分离及其活性筛选研究[J].中草药,2016,47(13):2288-2293.
[9]刘双双,刘丽芳,朱华旭,等.酶解等4种方法用于中药废弃物资源化研究初探(Ⅰ)-以脉络宁注射液生产中石斛药渣的多糖资源化研究为例[J].中国实验方剂学杂志,2016,22(22):34-40.
[10]戴新新,沈飞,宿树兰,等.丹参药渣中丹参酮类化学成分的提取富集研究及其利用途径分析[J].中国现代中药,2016,18(12):1578-1582.
[11]戴新新,沈飞,宿树兰,等.酸碱预处理后酶解提升丹参药渣中丹参酮类成分的提取效率研究[J].中国中药杂志,2016,41(18):3355-3360.
[12]宿树兰,段金廒,赵步长,等.一种应用糖化预处理方法从丹参药渣中提取制备丹参酮类成分的方法:CN201510007766.7[P].2015-01-07.
[13]WENG Z B,GUO S,QIAN D W,et al.Sophora flavescens Seed as a promising high potential by-product:Phytochemical characterization and bioactivity evaluation[J].Ind Crop Prod,2017,109:19-26.
[14]季浩,滕丰琳,窦长清.一种甘草次酸的提纯方法:CN201510234378.2[P].2015-05-08.
[15]季浩,阚建伟,徐娟.一种复合甜味剂及其制备方法:CN201510220799.X[P].2015-05-04.
[16]郭盛,段金廒,鲁学军,等.中药固体废弃物的热解炭化利用策略与研究实践[J].中国现代中药,2017,19(12):1665-1671.
[17]段金廒,鲁学军,钱大玮,等.利用中药材及中药生产过程废弃物制取生物炭的装置及其方法:CN201510644189.2[P].2015-09-30.
[18]段金廒,鲁学军,钱大玮,等.一种连续式无氧热解炭化机:CN 201520774529.9[P].2015-09-30.
[19]江曙,刘培,段金廒,等.基于微生物转化的中药废弃物利用价值提升策略探讨[J].世界科学技术-中医药现代化,2014,16(6):1210-1216.
[20]段金廒,曾飞,张森,等.一种耐受甘草药渣的纤维素酶产生菌及应用于甘草药渣产纤维素酶的方法:CN201710560473.0[P].2017-07-11.
[21]曾飞,张森,钱大玮,等.甘草药渣降解菌的筛选及其产酶工艺研究[J].生物技术通报,2017,33(12):125-131.
[22]马新飞,张森,段金廒,等.一种高产细菌多糖的菌株及其发酵中药废弃物制备多糖的方法:CN 201710077738.1[P].2017-02-14.
[23]张森,段金廒,陶伟伟,等.一种中间苍白杆菌胞外多糖及其在土壤改良方面的应用:CN 201710077783.7[P].2017-02-14.
[24]李会伟,段金廒,刘培,等.莲藕中白桦脂酸的微生物转化及其产物的抗肿瘤活性研究[J].南京中医药大学学报,2017,33(2):144-149.
[25]张森,段金廒,朱振华,等.一种解淀粉芽孢杆菌及在非水相中制备琥珀酰芒柄花苷的方法:ZL 2016 1 0719089.6[P].2016-08-24.
[26]张森,段金廒,刘培,等.一种高糖基转移活性解淀粉芽孢杆菌在非水相中生物合成红景天苷的应用:CN201811363071.2[P].2018-11-16.
[27]张森,段金廒,赵明,等.一种地衣芽孢杆菌及高效制备3'-琥珀酰木犀草苷及4'-琥珀酰木犀草苷的方法:CN201810747299.5[P].2018-07-09.
[28]ZHAO Y X,WANG J J,ZHANG L,et al.Bioactive luteoloside produced by Myroides odoratimimus,solvent-tolerant bacterium form the rhizosphere of Lonicera japonica[J].Nat Prod Res,2018,doi:10.1080/14786419.2018.1481838.
[29]ZHANG S,LI D D,ZENG F,et al.Efficient biosynthesis,analysis,solubility and anti-bacterial activities of succinylglycosylated naringenin[J].Nat Prod Res,2018,doi:10.1080/14786419.2018.1431633.
[30]段金廒,郭盛,钱大玮.一种富含纤维素类物质的中药药渣高值化综合利用的方法:CN 201510962054.0[P].2015-12-21.
[31]段金廒.中药废弃物的资源化利用[M].北京:化学工业出版社,2013.
[32]郭盛,段金廒,钱大玮,等.一种中药药渣生物质燃料颗粒及其制备方法:CN 201510746799.3[P].2015-11-05.
[33]严辉,张森,陈佩东,等.基于木塑产品开发的中药固体废弃物资源化利用研究[J].中国现代中药,2017,19(12):1677-1682.
[34]陈佩东,段金廒,严辉,等.一种用黄蜀葵秸秆制备塑木材料的方法:CN 201310494845.6[P].2013-10-21.
[35]严辉,段金廒,陈佩东,等.一种蒸爆解纤自胶结黄蜀葵纤维板的制备方法:CN 201310479642.X[P].2013-10-15.
[36]陶金华,段金廒,钱大玮,等.菊属药用植物资源化学研究进展[J].中国现代中药,2016,18(9):1212-1219,1229.
[37]TAO J H,DUAN J A,JIANG S,et al.Biotransformation and metabolic profile of buddleoside with human intestinal microflora by ultrahigh-performance liquid chromatography coupled to hybrid linear ion trap/orbitrap mass spectrometer[J].J Chromatogr B,2016,1025:7-15.
[38]TAO J H,DUAN J A,JIANG S,et al.Simultaneous determination of six short-chain fatty acids in colonic contents of colitis mice after oral administration of polysaccharides from Chrysanthemum morifolium Ramat by gas chromatography with flame ionization detector[J].J Chromatogr B,2016,1029:88-94.
[39]赵明,段金廒,张森,等.基于中药资源产业化过程副产物开发禽畜用药及饲料添加剂的策略与路径[J].中国中药杂志,2017,42(18):3628-3632.
[40]顾俊菲,宿树兰,彭珂毓,等.丹参地上部分资源价值发现与开发利用策略[J].中国现代中药,2017,19(12):1659-1664.
[41]ZENG H T,SU S L,XIANG X,et al.Comparative Analysis of the Major Chemical Constituents in Salvia miltiorrhiza Roots,Stems,Leaves and Flowers during Different Growth Periods by UPLC-TQ-MS/MS and HPLC-ELSD Methods[J].Molecules,2017,22:771.
[42]GU J F,SU S L,GUO J M,et al.The aerial parts of Salvia miltiorrhiza Bge.strengthen intestinal barrier and modulate gut microbiota imbalance in streptozocin-induced diabetic mice[J].J Funct Food,2017,36:362-374.
[43]宿树兰,段金廒,江曙,等.利用生物转化技术从丹参地上茎叶中高效制备丹参酚酸类成分的方法:CN 201510070147.2[P].2015-02-10.
[44]张贻昌,王明耿.中药产品质量过程控制的重要性[J].中成药,2012,34(8):1581-1585.
[45]LIU H B,TANG Z S,CUI C L,et al.Fouling mechanisms of the extract of traditional Chinese medicine in ultrafiltration[J].Desalination,2014,354:87-96.
[46]GUO S,DUAN J A,LI Y Q,et al.Comparison of the Bioactive Components in Two Seeds of Ziziphus Species by Different Analytical Approaches Combined with Chemometrics[J].Front Pharmacol,2017,8:609.
[47]GUO S,DUAN J A,TANG Y P,et al.Simultaneous qualitative and quantitative analysis of triterpenic acids,saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD[J].J Pharm Biomed Anal,2011,56(2):264-270.
[48]段金廒,郭盛,钱大玮.酸枣的活性部位及其制备方法与应用:ZL 2012 1 0137229.0[P].2013-11-06.
[49]唐志书,张严磊,段金廒,等.一种提取酸枣渣中可溶性与不溶性膳食纤维的制备方法:ZL 2015 1 0617096.0[P].2018-03-27.
[50]张严磊,唐志书,宋忠兴,等.一种酸枣核壳木糖及二氧化硅的制备方法:ZL 2015 1 0615309.6[P].2018-01-02.