补肾活血汤治疗帕金森病对其运动症状及生活质量的影响
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摘要
目的:观察补肾活血汤用于临床治疗帕金森病的临床疗效。方法:将患者80例按照随机数字表法分为2组各40例。对照组给予普拉克索片、美多芭治疗;观察组在对照组治疗基础上采用自拟中药汤剂补肾活血汤治疗。采用帕金森病评定量表(UPDRS)评价其临床疗效,采用帕金森病运动功能量表(MDRSPD)评价其运动功能,采用生活质量问卷调查其生活质量,记录治疗期间不良反应。结果:治疗前,2组MDRSPD、UPDRS评分比较,差异无统计学意义(P> 0.05)。2组治疗后1、3、6个月时MDRSPD、UPDRS评分低于治疗前(P <0.05),且治疗6个月时MDRSPD、UPDRS评分低于1、3个月(P <0.05),治疗3个月时MDRSPD、UPDRS评分低于治疗1个月(P <0.05)。治疗1、3、6个月时,2组间比较,差异有统计学意义(P <0.05)。治疗前,2组生活质量评分比较,差异无统计学意义(P>0.05)。治疗后,2组生活质量评分均提高(P<0.05),观察组治疗后评分高于对照组(P<0.05)。不良反应发生率观察组为5.0%,对照组为10.0%,2组比较,差异无统计学意义(χ2=0.720,P=0.395)。结论:采用自拟中药汤剂补肾活血汤联合西药治疗帕金森病可显著改善其运动症状,提高临床疗效,改善患者生活质量,且不会增加不良反应。
Objective:To observe the clinical effect of Bushen Huoxue tang in clinical treatment of Parkinson diseases. Methods:Divided 80 cases of patients into two groups,40 cases in each group according to random number table. The control group was treated with pramipexole tablets and Madopar, and the observation group was additionally treated with Bushen Huoxue tang. Evaluated the clinical effect by Parkinson diseases rating scale(UPDRS) and the motor function by Parkinson diseases motor function scale(MDRSPD),investigated the the quality of life by quality of life questionnaire, and recorded the adverse reactions during the treatment. Results:Before treatment,there was no significant differences being found in the comparison of MDRSPD and UPDRS scores between the two groups(P > 0.05). The MDRSPD and UPDRS scores of the two groups at 1,3,and 6 months after treatment were lower than those before treatment(P < 0.05);the MDRSPD and UPDRS scores at 6 months of treatment were lower than those at 1 and 3 months(P <0.05);the MDRSPD and UPDRS scores at 3 months of treatment was lower than that at 1 month(P < 0.05). At 1,3,and 6 months of treatment,there was no significant differences being found in the comparison of the two groups(P < 0.05). Before treatment,there was no significant differences being found in the comparison of the scores of quality of life in the two groups(P > 0.05). After treatment,the scores of quality of life in the two groups were increased(P < 0.05),and the score in the observation group was higher than that in the control group(P < 0.05). The adverse reaction rate was 5.0% in the observation group and 10.0% in the control group,compared the two groups, difference being insignificant(χ2=0.720, P=0.395). Conclusion: The use of Bushen Huoxue tang combined with western medicine for Parkinson diseases can significantly improve motor symptoms,promote clinical effect and quality of life of patients. It will not increase adverse reactions.
Objective:To observe the clinical effect of Bushen Huoxue tang in clinical treatment of Parkinson diseases. Methods:Divided 80 cases of patients into two groups,40 cases in each group according to random number table. The control group was treated with pramipexole tablets and Madopar, and the observation group was additionally treated with Bushen Huoxue tang. Evaluated the clinical effect by Parkinson diseases rating scale(UPDRS) and the motor function by Parkinson diseases motor function scale(MDRSPD),investigated the the quality of life by quality of life questionnaire, and recorded the adverse reactions during the treatment. Results:Before treatment,there was no significant differences being found in the comparison of MDRSPD and UPDRS scores between the two groups(P > 0.05). The MDRSPD and UPDRS scores of the two groups at 1,3,and 6 months after treatment were lower than those before treatment(P < 0.05);the MDRSPD and UPDRS scores at 6 months of treatment were lower than those at 1 and 3 months(P <0.05);the MDRSPD and UPDRS scores at 3 months of treatment was lower than that at 1 month(P < 0.05). At 1,3,and 6 months of treatment,there was no significant differences being found in the comparison of the two groups(P < 0.05). Before treatment,there was no significant differences being found in the comparison of the scores of quality of life in the two groups(P > 0.05). After treatment,the scores of quality of life in the two groups were increased(P < 0.05),and the score in the observation group was higher than that in the control group(P < 0.05). The adverse reaction rate was 5.0% in the observation group and 10.0% in the control group,compared the two groups, difference being insignificant(χ2=0.720, P=0.395). Conclusion: The use of Bushen Huoxue tang combined with western medicine for Parkinson diseases can significantly improve motor symptoms,promote clinical effect and quality of life of patients. It will not increase adverse reactions.
引文
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[5]王彦.补肾活血通络胶囊治疗原发性帕金森病临床疗效观察[J].中国继续医学教育,2015,7(17):188-189.
[6]邓晓红,黄建华,董竞成.附子药理作用的分子机制研究进展[J].江西中医药大学学报,2018,30(1):121-124.
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[8]林艳,肖榕,李春,等.生/制/发酵何首乌化学成分、药理作用及肝毒性研究进展[J].中药新药与临床药理,2018,29(5):661-672.
[9]刘倩,余意,梁琰,等.枸杞子活性成分及分析方法研究进展[J].辽宁中医药大学学报,2018,20(11):1-4.
[10]雷小小,苏艳莹,李美云,等.山茱萸环烯醚萜苷中马钱苷和莫诺苷的研究进展[J].上海中医药杂志,2018,52(1):104-108.
[11]杨倩,吕莉莉,孙蓉.基于网络药理学的丹参川芎嗪注射液作用机制分析[J].中草药,2018,49(11):2606-2613.
[12]田莎,田雪飞,黄晓蒂,等.蜈蚣药理作用、临床用量及毒性研究概况[J].湖南中医杂志,2018,34(5):212-214.
[2]中华医学会神经病学分会运动障碍及帕金森病学组.帕金森病的诊断[J].中华神经科杂志,2006,39(6):408-409.
[3]佚名.中医老年颤证诊断和疗效评定标准(试行)[J].山东中医学院学报,1992(6):55.
[4]李彪,汪瀚,杨文明.中医药治疗帕金森病临床研究进展[J].辽宁中医药大学学报,2017,19(7):130-133.
[5]王彦.补肾活血通络胶囊治疗原发性帕金森病临床疗效观察[J].中国继续医学教育,2015,7(17):188-189.
[6]邓晓红,黄建华,董竞成.附子药理作用的分子机制研究进展[J].江西中医药大学学报,2018,30(1):121-124.
[7] TUNJE R,叶阳烈,SONAUDDIN A,等.首乌熟地饮对MPTP致帕金森病小鼠模型多巴胺能神经元的影响[J].中国中药杂志,2016,41(18):3439-3442.
[8]林艳,肖榕,李春,等.生/制/发酵何首乌化学成分、药理作用及肝毒性研究进展[J].中药新药与临床药理,2018,29(5):661-672.
[9]刘倩,余意,梁琰,等.枸杞子活性成分及分析方法研究进展[J].辽宁中医药大学学报,2018,20(11):1-4.
[10]雷小小,苏艳莹,李美云,等.山茱萸环烯醚萜苷中马钱苷和莫诺苷的研究进展[J].上海中医药杂志,2018,52(1):104-108.
[11]杨倩,吕莉莉,孙蓉.基于网络药理学的丹参川芎嗪注射液作用机制分析[J].中草药,2018,49(11):2606-2613.
[12]田莎,田雪飞,黄晓蒂,等.蜈蚣药理作用、临床用量及毒性研究概况[J].湖南中医杂志,2018,34(5):212-214.