miR-143与骨肉瘤的研究进展
摘要
随着新辅助化疗结合保肢术方法的完善,骨肉瘤患者5年生存率有所提高,但是化疗抵抗和肺转移仍是骨肉瘤不良预后的重要原因和难以逾越的屏障。近年来,随着微RNA(miRNA)与骨肉瘤发病机制关系的研究逐年增加,发现骨肉瘤患者中miRNA表达的差异性与其发病密切相关;同时发现miRNA对骨肉瘤的诊断和预后的判断有一定的意义。其中,miRNA-143(miR-143)可能作为抑癌基因参与了骨肉瘤的发生、发展。骨肉瘤发病与体内miR-143下降密切相关,且伴随着miR-143基因表达升高,骨肉瘤细胞的增殖、凋亡以及侵袭和转移的能力有所改变。本文阐述了具有预后标志物潜能的miR-143调控的基因(K-ras、Bcl-2、PAI-1等)与骨肉瘤发生、发展和转移之间的关系。
引文
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[28] Liu Z,Liu Z,Zhang Y,et al.miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway[J].Biochem Biophys Res Commun,2017,486(2):211-217.
[29] Hirahata M,Osaki M,Kanda Y,et al.PAI-1,a target gene of miR-143,regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma[J].Cancer Med,2016,5(5):892-902.
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[34] Li DC,Zhang F,Yan WJ.Effect of miR-143 on proliferation of osteosarcoma cells under low dosage cisplatin[J].Int J Clin Exp Pathol,2016,9(1):124-128.
[2] Reed DR,Hayashi M,Wagner L,et al.Treatment Pathway of Bone Sarcoma in Children,Adolescents,and Young Adults[J].Cancer,2017,123(12):2206-2218.
[3] Palmini G,Marini F,Brandi ML.What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma?[J].Molecules,2017,22(3):E417.
[4] Kumar RM,Boro A,Fuchs B.Involvement and Clinical Aspects of MicroRNA in Osteosarcoma[J].Int J Mol Sci,2016,17(6):E877.
[5] Zhu KP,Zhang CL,Shen GQ,et al.Long noncoding RNA expression profiles of the doxorubicin-resistant human osteosarcoma cell line MG63/DXR and its parental cell line MG63 as ascertained by microarray analysis[J].Int J Clin Exp Pathol,2015,8(8):8754-8773.
[6] Zhao F,Lv J,Gan H,et al.MiRNA profile of osteosarcoma with CD117 and stro-1 expression:miR-1247 functions as an onco-miRNA by targeting MAP3K9[J].Int J Clin Exp Pathol,2015,8(2):1451-1458.
[7] Hutanu D,Popescu R,Stefanescu H,et al.The Molecular Gene-tic Expression as a Novel Biomarker in the Evaluation and Monitoring of Patients With Osteosarcoma-Subtype Bone Cancer Disease[J].Biochem Genet,2017,55(4):291-299.
[8] Kushlinskii NE,Fridman MV,Braga EA.Molecular Mechanisms and microRNAs in Osteosarcoma Pathogenesis[J].Biochemistry (Mosc),2016,81(4):315-328.
[9] Ouyang L,Liu P,Yang S,et al.A three-plasma miRNA signature serves as novel biomarkers for osteosarcoma[J].Med Oncol,2013,30(1):340.
[10] Wei GJ,Li C,Yao M,et al.Identification of microRNA-143 as a prognostic marker for survival in patients with osteosarcoma[J].Int J Clin Exp Pathol,2017,10(3):3753-3757.
[11] Fang Y,Zhang Z,Wang Q,et al.Expression and clinical significance of cyclooxygenase-2 and microRNA-143 in osteosarcoma[J].Exp Ther Med,2015,9(6):2374-2378.
[12] Lian J,Guo J,Huang X,et al.miRNAs Regulate hERG[J].J Cardiovasc Electrophysiol,2016,27(12):1472-1482.
[13] 吴进,陈志达,曾文容,等.HERG基因调控NF-κB 通道抑制骨肉瘤恶性表型的研究[J].国际肿瘤学杂志,2016,43(7):508-514.
[14] Zhou J,Wu S,Chen Y,et al.microRNA-143 is associated with the survival of ALDH1+CD133+ osteosarcoma cells and the chemoresistance of osteosarcoma[J].Exp Biol Med (Maywood),2015,240(7):867-875.
[15] Li WH,Wu HJ,Li YX,et al.MicroRNA-143 promotes apoptosis of osteosarcoma cells by caspase-3 activation via targeting Bcl-2[J].Biomed Pharmacother,2016,80:8-15.
[16] Na KY,Kim YW,Park YK.Mitogen-activated protein kinase pathway in osteosarcoma[J].Pathology,2012,44(6):540-546.
[17] Sun Y,Liu WZ,Liu T,et al.Signaling pathway of MAPK/ERK in cell proliferation,differentiation,migration,senescence and apoptosis[J].J Recept Signal Transduct Res,2015,35(6):600-604.
[18] Wang JL,Lu L,Huang K,et al.miR-143 inhibits osteosarcoma cell proliferation by down-regulating K-ras expression[J].Int J Clin Exp Pathol,2016,9(3):3436-3441.
[19] Wang Q,Cai J,Wang J,et al.MiR-143 inhibits EGFR-signaling-dependent osteosarcoma invasion[J].Tumour Biol,2014,35(12):12743-12748.
[20] Dong X,Lv B,Li Y,et al.MiR-143 regulates the proliferation and migration of osteosarcoma cells through targeting MAPK7[J].Arch Biochem Biophys,2017,630:47-53.
[21] 柳豪.miR-143在骨肉瘤细胞中的作用及机制研究[D].济南:山东大学,2017.
[22] Ma Z,Luo Y,Qiu M.miR-143 Induces the Apoptosis of Prostate Cancer LNCap Cells by Suppressing Bcl-2 Expression[J].Med Sci Monit,2017,23:359-365.
[23] Liu H,Wang H,Liu H,et al.Effect of miR-143 on the apoptosis of osteosarcoma cells[J].Int J Clin Exp Pathol,2015,8(11):14241-14246.
[24] Zhang H,Wang G,Ding C,et al.Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.[J].Oncotarget,2017,8(37):61687-61697.
[25] Santibanez JF,Obradovic H,Kukolj T,et al.Transforming Growth Factor-beta,Matrix Metalloproteinases and Urokinase-Type Plasminogen Activator Interaction in the Cancer Epithelial to Mesenchymal Transition[J].Dev Dyn,2018,247(3):382-395.
[26] Osaki M,Takeshita F,Sugimoto Y,et al.MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression[J].Mol Ther,2011,19(6):1123-1130.
[27] 李勇,齐巍,王保苍,等.miR-143过表达对骨肉瘤143B细胞侵袭和迁移能力的影响[J].广东医学,2017,38(12):1809-1813.
[28] Liu Z,Liu Z,Zhang Y,et al.miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway[J].Biochem Biophys Res Commun,2017,486(2):211-217.
[29] Hirahata M,Osaki M,Kanda Y,et al.PAI-1,a target gene of miR-143,regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma[J].Cancer Med,2016,5(5):892-902.
[30] Li F,Li S,Cheng T.TGF-beta1 promotes osteosarcoma cell migration and invasion through the miR-143-versican pathway[J].Cell Physiol Biochem,2014,34(6):2169-2179.
[31] 姜珍.miR-143-3p调控人骨肉瘤(OS)肺转移的分子机制[D].苏州:苏州大学,2015.
[32] Li Y,Zhang J,Zhang L,et al.Diallyl trisulfide inhibits proliferation,invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling[J].Carcinogenesis,2013,34(7):1601-1610.
[33] Ye Z,Jingzhong L,Yangbo L,et al.Propofol inhibits proliferation and invasion of osteosarcoma cells by regulation of microRNA-143 expression[J].Oncol Res,2013,21(4):201-207.
[34] Li DC,Zhang F,Yan WJ.Effect of miR-143 on proliferation of osteosarcoma cells under low dosage cisplatin[J].Int J Clin Exp Pathol,2016,9(1):124-128.