生物钟紊乱导致护士患乳腺癌风险的研究进展
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摘要
大多数生物都存在生物钟,也称生物节律,人类也不例外,但是外界环境刺激可以强化、减弱甚至破坏这种节律。由于护理行业的特殊性,护理人员实行轮班制,而不规则轮班会打破生活作息导致昼夜颠倒、生物节律紊乱。动物实验和人群流行病学研究表明,生物节律紊乱与乳腺癌的发病危险相关,但其机制尚未确定。现研究较多的是多种生物钟基因的自主调节的负反馈循环障碍及昼夜节律紊乱导致体内激素水平异常。本文就国内外的研究现况对不规则轮班、生物节律紊乱和乳腺癌之间的关联进行综述,为护理管理者排班提供依据,更好地预防护士患乳腺癌的风险和改善其身心健康。
Most organisms have biological clocks, also known as biological rhythms, human beings are no exception,but external environmental stimuli can strengthen, weaken or even destroy this rhythm. Because of the particularity of nursing profession, nurses carry out shift system, and irregular shift will break the daily life and rest and lead to the reversal of day and night and the disorder of biological rhythm. Animal experiments and population epidemiological studies show that the disorder of biological rhythm is associated with the risk of breast cancer, but its mechanism has not been determined. Now it is more studied that the negative feedback circulatory disorder and circadian rhythm disorder caused by the autonomic regulation of many biological clock genes lead to abnormal hormone levels in the body. In this paper, the relationship among irregular shift, biological rhythm disorder and breast cancer was reviewed in order to provide basis for nursing managers to work on shifts, to prevent breast cancer risk for nurses and to improve their physical and mental health.
Most organisms have biological clocks, also known as biological rhythms, human beings are no exception,but external environmental stimuli can strengthen, weaken or even destroy this rhythm. Because of the particularity of nursing profession, nurses carry out shift system, and irregular shift will break the daily life and rest and lead to the reversal of day and night and the disorder of biological rhythm. Animal experiments and population epidemiological studies show that the disorder of biological rhythm is associated with the risk of breast cancer, but its mechanism has not been determined. Now it is more studied that the negative feedback circulatory disorder and circadian rhythm disorder caused by the autonomic regulation of many biological clock genes lead to abnormal hormone levels in the body. In this paper, the relationship among irregular shift, biological rhythm disorder and breast cancer was reviewed in order to provide basis for nursing managers to work on shifts, to prevent breast cancer risk for nurses and to improve their physical and mental health.
引文
[1]Siegel RL,Miller KD,Jemal A.Cancer statistics,2017[J].CA Cancer J Clin,2017,67(1):7-30.
[2] Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-32.
[3]陈万青,郑荣寿.中国女性乳腺癌发病死亡和生存状况[J].中国肿瘤临床,2015,42(13):668-674.
[4]宋宛芝,高晋南,杨海波.乳腺癌的流行状况及发病特征[J].中国药物与临床,2017,17(2):228-229.
[5]李贺,郑荣寿,张思维,等.2014年中国女性乳腺癌发病与死亡分析[J].中华肿瘤杂志,2018,40(3):166-171.
[6]Shostak A.Circadian clock,cell division,and cancer:from molecules to organism[J].Int J Mol Sci,2017,18(4):873.
[7]Blakeman V,Williams JL,Meng QJ,et al.Circadian clocks and breast cancer[J].Breast Cancer Res,2016,18(1):89.
[8]Reszka E,Przybek M,Muurlink O,e t al.Circadian gene variants and breast cancer[J].Cancer Lett,2017,390:137-145.
[9]Wang XS,Armstrong ME,Cairns BJ,et al.Shift work and chronic disease:the epidemiological evidence[J].Occup Med(Lond),2011,61(2):78-89.
[10]Hansen J.Women with night shift work and breast cancer:the situation in Denmark[J].J Epidemiol Community Health,2010,64(12):1025-1026.
[11]Bracci M,Manzella N,Copertaro A,et al.Rotating-shift nurses after a day off:peripheral clock gene expression,urinary melatonin,and serum 17-β-estradiol levels[J].Scand J Work Environ Health,2014,40(3):295-304.
[12]Schernhammer ES,Laden F,Speizer FE,et al.rotating night shifts and risk of breast cancer in women participating in the nurses′health study[J].J Natl Cancer Inst,2001,93(20):1563-8.
[13]Jia Y,Lu Y,Wu K,et al.Does night work increase the risk of breast cancer? a systematic review and meta-analysis of epidemiological studies[J].Cancer Epidemiol,2013,37(3):197-206.
[14]Travis RC,Balkwill A,Fensom GK,et al.Night shift work and breast cancer incidence:three prospective studies and meta-analysis of published studies[J].J Natl Cancer Inst,2016,108(12):169.
[15]Wegrzyn LR,Tamimi RM,Brown SB,et al.Rotating night shift work and risk of breast cancer in the nurses’ health studies[J].Am J Epidemiol,2017,186(5):532-540.
[16]Kandalepas PC,Mitchell JW,Gillette MU.Melatonin signal transduction pathways require E-box-mediated transcription of Per1 and Per2 to reset the SCN clock at dusk[J].PLoS One,2016,11(6):e0157824.
[17]Casey TM,Crodian J,Erickson E,et al.Tissue-specific changes in molecular clocks during the transition from pregnancy to lactation in mice[J].Biol Reprod,2014,90(6):127.
[18]Li Y,Li S,Zhou Y,et al.Melatonin for the prevention and treatment of cancer[J].Oncotarget,2017,8(24):39 896-39921.
[19]Hansen J.Night shift work and risk of breast cancer[J].Curr Environ Health Rep,2017,4(3):325-339.
[20]Nooshinfar E,Safaroghli-Azar A,Bashash D,et al.Melatonin,an inhibitory agent in breast cancer[J].Breast Cancer,2017,24(1):42-51.
[21]James P,Bertrand KA,Hart JE,et al.Outdoor light at night and breast cancer incidence in the nurses′health studyⅡ[J].Environ Health Perspect,2017,125(8):087 010.
[22]Oh H,Eliassen AH,Beck AH,et al.Breast cancer risk factors in relation to estrogen receptor,progesterone receptor,insulin-like growth factor-1 receptor,and Ki67 expression in normal breast tissue[J].NPJ Breast Cancer,2017,3(1):39.
[23]Devore EE,Warner ET,Eliassen H,et al.Urinary melatonin in relation to postmenopausal breast cancer risk according to melatonin 1 receptor status[J].Cancer Epidemiol Biomarkers Prev,2017,26(3):413-419.
[24]Danforth DN Jr,Tamarkin L,Mulvihill JJ,et al.Plasma melatonin and the hormonedependency of human breast cancer[J].J Clin Oncol,1985,3(7):941-948.
[25]Knauth P,Hornberger S.Preventive and compensatory measures for shift workers[J].Occap Med(Lond),2003,53(2):109-116.
[26]王莉月,赵桂兰,尤柯,等.对夜班护士内分泌节律变化的观察及探讨[J].中华护理杂志,1992,27(5):198-200.
[27]王瑞华,华云,高芸.小循月换夜班法的临床实践与研究[J].中国实用护理杂志,1993,9(5):38-41.
[28]林燕玲,樊粤光.护士夜班排班方式的改革[J].护理学报,2000,7(4):54-55.
[29]李晶,杨丽君,张静平.专职夜班排班模式的研究进展[J].中华现代护理杂志,2013,19(12):1472-1473.
[30]Keshet-Sitton A,Or-Chen K,Yitzhak S,et al.Can Avoiding Light at Night Reduce the Risk of Breast Cancer[J].Integr Cancer Ther,2016,15(2):145-52.
[31]Stevens RG,Brainard GC,David E,et al.Breast cancer and circadian disruption from electric lighting in the modern world[J].CA Cancer J Clin,2014,64(3):207-218.
[32]张保宁.国际乳腺癌筛查指南的争议引发的思考[J].癌症进展,2016,14(2):109-111.
[33]Ranzese E,Nigri G.Night work as a possible risk factor for breast cancer in nurses.Correlation between the onset of tumors and alterations in blood melatonin levels[J].Prof Inferm,2007,60(2):89-93.
[2] Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-32.
[3]陈万青,郑荣寿.中国女性乳腺癌发病死亡和生存状况[J].中国肿瘤临床,2015,42(13):668-674.
[4]宋宛芝,高晋南,杨海波.乳腺癌的流行状况及发病特征[J].中国药物与临床,2017,17(2):228-229.
[5]李贺,郑荣寿,张思维,等.2014年中国女性乳腺癌发病与死亡分析[J].中华肿瘤杂志,2018,40(3):166-171.
[6]Shostak A.Circadian clock,cell division,and cancer:from molecules to organism[J].Int J Mol Sci,2017,18(4):873.
[7]Blakeman V,Williams JL,Meng QJ,et al.Circadian clocks and breast cancer[J].Breast Cancer Res,2016,18(1):89.
[8]Reszka E,Przybek M,Muurlink O,e t al.Circadian gene variants and breast cancer[J].Cancer Lett,2017,390:137-145.
[9]Wang XS,Armstrong ME,Cairns BJ,et al.Shift work and chronic disease:the epidemiological evidence[J].Occup Med(Lond),2011,61(2):78-89.
[10]Hansen J.Women with night shift work and breast cancer:the situation in Denmark[J].J Epidemiol Community Health,2010,64(12):1025-1026.
[11]Bracci M,Manzella N,Copertaro A,et al.Rotating-shift nurses after a day off:peripheral clock gene expression,urinary melatonin,and serum 17-β-estradiol levels[J].Scand J Work Environ Health,2014,40(3):295-304.
[12]Schernhammer ES,Laden F,Speizer FE,et al.rotating night shifts and risk of breast cancer in women participating in the nurses′health study[J].J Natl Cancer Inst,2001,93(20):1563-8.
[13]Jia Y,Lu Y,Wu K,et al.Does night work increase the risk of breast cancer? a systematic review and meta-analysis of epidemiological studies[J].Cancer Epidemiol,2013,37(3):197-206.
[14]Travis RC,Balkwill A,Fensom GK,et al.Night shift work and breast cancer incidence:three prospective studies and meta-analysis of published studies[J].J Natl Cancer Inst,2016,108(12):169.
[15]Wegrzyn LR,Tamimi RM,Brown SB,et al.Rotating night shift work and risk of breast cancer in the nurses’ health studies[J].Am J Epidemiol,2017,186(5):532-540.
[16]Kandalepas PC,Mitchell JW,Gillette MU.Melatonin signal transduction pathways require E-box-mediated transcription of Per1 and Per2 to reset the SCN clock at dusk[J].PLoS One,2016,11(6):e0157824.
[17]Casey TM,Crodian J,Erickson E,et al.Tissue-specific changes in molecular clocks during the transition from pregnancy to lactation in mice[J].Biol Reprod,2014,90(6):127.
[18]Li Y,Li S,Zhou Y,et al.Melatonin for the prevention and treatment of cancer[J].Oncotarget,2017,8(24):39 896-39921.
[19]Hansen J.Night shift work and risk of breast cancer[J].Curr Environ Health Rep,2017,4(3):325-339.
[20]Nooshinfar E,Safaroghli-Azar A,Bashash D,et al.Melatonin,an inhibitory agent in breast cancer[J].Breast Cancer,2017,24(1):42-51.
[21]James P,Bertrand KA,Hart JE,et al.Outdoor light at night and breast cancer incidence in the nurses′health studyⅡ[J].Environ Health Perspect,2017,125(8):087 010.
[22]Oh H,Eliassen AH,Beck AH,et al.Breast cancer risk factors in relation to estrogen receptor,progesterone receptor,insulin-like growth factor-1 receptor,and Ki67 expression in normal breast tissue[J].NPJ Breast Cancer,2017,3(1):39.
[23]Devore EE,Warner ET,Eliassen H,et al.Urinary melatonin in relation to postmenopausal breast cancer risk according to melatonin 1 receptor status[J].Cancer Epidemiol Biomarkers Prev,2017,26(3):413-419.
[24]Danforth DN Jr,Tamarkin L,Mulvihill JJ,et al.Plasma melatonin and the hormonedependency of human breast cancer[J].J Clin Oncol,1985,3(7):941-948.
[25]Knauth P,Hornberger S.Preventive and compensatory measures for shift workers[J].Occap Med(Lond),2003,53(2):109-116.
[26]王莉月,赵桂兰,尤柯,等.对夜班护士内分泌节律变化的观察及探讨[J].中华护理杂志,1992,27(5):198-200.
[27]王瑞华,华云,高芸.小循月换夜班法的临床实践与研究[J].中国实用护理杂志,1993,9(5):38-41.
[28]林燕玲,樊粤光.护士夜班排班方式的改革[J].护理学报,2000,7(4):54-55.
[29]李晶,杨丽君,张静平.专职夜班排班模式的研究进展[J].中华现代护理杂志,2013,19(12):1472-1473.
[30]Keshet-Sitton A,Or-Chen K,Yitzhak S,et al.Can Avoiding Light at Night Reduce the Risk of Breast Cancer[J].Integr Cancer Ther,2016,15(2):145-52.
[31]Stevens RG,Brainard GC,David E,et al.Breast cancer and circadian disruption from electric lighting in the modern world[J].CA Cancer J Clin,2014,64(3):207-218.
[32]张保宁.国际乳腺癌筛查指南的争议引发的思考[J].癌症进展,2016,14(2):109-111.
[33]Ranzese E,Nigri G.Night work as a possible risk factor for breast cancer in nurses.Correlation between the onset of tumors and alterations in blood melatonin levels[J].Prof Inferm,2007,60(2):89-93.