女性健康体检人群生殖道支原体和衣原体感染状况的调查
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摘要
目的:了解福州地区健康体检人群女性生殖道支原体和衣原体的感染状况,指导女性健康体检人群在体检时有选择性的筛查,能够更好地指导感染者及时就医。方法:选择2017年1月-2018年1月来本院体检中心体检的福州地区妇女860例,其中支原体检查860例,衣原体检查757例,取宫颈分泌物做Uu(解脲脲原体)、Mh(人型支原体)检测,并对阳性者做药敏试验;取宫颈分泌物做CT(沙眼衣原体)抗原检测。结果:健康体检者支原体阳性率51.4%,衣原体阳性率2.25%;支原体感染以Uu+为主,Uu+Mh+次之;支原体感染各年龄组阳性率不同。衣原体感染各年龄组阳性率不同,其中18～20岁阳性率0、21～30岁阳性率2.4%(6/247)、31～40岁阳性率1.8%(6/340)、41～50岁阳性率3.5%(4/114)、51～60岁阳性率2.2%(1/45)、61岁以上阳性率0。由于18～20岁和61岁以上支原体感染和衣原体感染总标本数太少不进行统计,支原体感染和衣原体感染都以41～50岁阳性率最高,分别为62.9%和3.5%,与其他年龄组比较差异有统计学意义(P<0.05)。结论:福州地区健康体检者支原体感染率高达到51.4%,尤以41～50岁为甚达到62.9%,其双重感染(Uu+Mh+)率达到16.4%;衣原体感染率较低2.25%,41～50岁达到3.5%;女性健康体检中要注重支原体检查和沙眼衣原体检测来提升女性生殖健康、优生优育以及防止性疾病传播均具有重要意义。
Objective:To understand the infection status of female genital tract mycoplasma and chlamydia in healthy checkup population in Fuzhou area,and to guide women's health checkups to selective screening during physical examination,so as to better guide the infected person to seek medical advice in time. Method:860 women were examined in the Fuzhou area of the physical examination center were selected from January 2017 to January 2018,757 cases of mycoplasma were examined by mycoplasma,the Uu(Ureaplasma urealyticum)and MH(Mycoplasma hominis)were detected by cervical secretions.Positive people was given drug susceptibility testing,the cervical secretions was given CT(Chlamydia trachomatis)antigen test.Result:The positive rate of chlamydia was 51.4% and the positive rate of chlamydia was 2.25%.The mycoplasma infection was mainly Uu+,followed by Uu+MH+.The positive rate of mycoplasma infection varies from age to age.Chlamydia infection rates vary among age groups,of which the positive rate of 18-20 years old was 0,the positive rate of 21-30 years old was 2.4%(6/247),31-40 years old positive rate was 1.8%(6/314),the 41-50 years old positive rate was 5.3%(4/114),the 51-60 years old positive rate was 2.2%(1/45),the positive rate 61 years old or older was 0.Since the total number of specimens of mycoplasma and chlamydia infections below the age of 20 and 61 years was too small to be counted,mycoplasma and chlamydial infections were highest in 41-50 years old,with the highest rates of 62.9% and 5.3%,respectively,compared with other age-matched groups,the difference was statistically significant(P<0.05).Conclusion:The high rate of mycoplasma infection in health examinations in Fuzhou was 51.4%,especially in 41-50 years old,which was 62.9%.The rate of dual infection(Uu+MH+)reached 4.16.%,chlamydial infection rate is lower 2.25%,41-50 years old reached 3.5%.It is important to pay attention to mycoplasma screening and chlamydia chlamydia detection in women's health physical examination to promote women's reproductive health,healthy birth and prevent disease transmission.
Objective:To understand the infection status of female genital tract mycoplasma and chlamydia in healthy checkup population in Fuzhou area,and to guide women's health checkups to selective screening during physical examination,so as to better guide the infected person to seek medical advice in time. Method:860 women were examined in the Fuzhou area of the physical examination center were selected from January 2017 to January 2018,757 cases of mycoplasma were examined by mycoplasma,the Uu(Ureaplasma urealyticum)and MH(Mycoplasma hominis)were detected by cervical secretions.Positive people was given drug susceptibility testing,the cervical secretions was given CT(Chlamydia trachomatis)antigen test.Result:The positive rate of chlamydia was 51.4% and the positive rate of chlamydia was 2.25%.The mycoplasma infection was mainly Uu+,followed by Uu+MH+.The positive rate of mycoplasma infection varies from age to age.Chlamydia infection rates vary among age groups,of which the positive rate of 18-20 years old was 0,the positive rate of 21-30 years old was 2.4%(6/247),31-40 years old positive rate was 1.8%(6/314),the 41-50 years old positive rate was 5.3%(4/114),the 51-60 years old positive rate was 2.2%(1/45),the positive rate 61 years old or older was 0.Since the total number of specimens of mycoplasma and chlamydia infections below the age of 20 and 61 years was too small to be counted,mycoplasma and chlamydial infections were highest in 41-50 years old,with the highest rates of 62.9% and 5.3%,respectively,compared with other age-matched groups,the difference was statistically significant(P<0.05).Conclusion:The high rate of mycoplasma infection in health examinations in Fuzhou was 51.4%,especially in 41-50 years old,which was 62.9%.The rate of dual infection(Uu+MH+)reached 4.16.%,chlamydial infection rate is lower 2.25%,41-50 years old reached 3.5%.It is important to pay attention to mycoplasma screening and chlamydia chlamydia detection in women's health physical examination to promote women's reproductive health,healthy birth and prevent disease transmission.
引文
[1]卢大乔,熊冰,周长春,等.泌尿生殖道性病感染病原体分布与耐药性分析[J].中华医院感染学杂志,2016,26(2):363-365.
[2]周丽华,沈梦远,李曦,等.12548例泌尿生殖道标本解脲尿原体和人型支原体检测及药物敏感性分析[J].中国卫生检验杂志,2018(1):120-125.
[3]韩泽平,林学良,何金花,等.广州市番禺区五种性传播疾病的流行病学分析[J].中国优生与遗传杂志,2016(8):18-20.
[4]Handsfield H H.Sexually Transmitted Diseases,Infections,and Disorders:What’s in a Name[J].Sexually Transmitted Diseases,2015,42(4):169.
[5]任翊,刘朝晖,朱学骏.妇科门诊人群宫颈解脲支原体检出情况及分群分型[J].中国皮肤性病学杂志,2002,16(3):155-157.
[6]张帝开,李秀云,覃春容,等.健康妇女下生殖道解脲脲原体及其分群分型研究[J].中国微生态学杂志,2007,19(3):288-289,292.
[7]Mindel A,Dwyer D,Herring B,et al.Global Epidemiology of Sexually Transmitted Diseases[J].Elsevier Ltd,2013,351 Suppl3(1):3-43.
[8]张欠欠,仵恒立,胡军婷,等.荧光定量PCR检测淋球菌、沙眼衣原体和解脲脲原体结果分析[J].中国人兽共患病学报,2016,32(3):312-314.
[9]周侃,魏瑜,周迪.417例女性生殖道感染沙眼衣原体和解脲支原体检测结果分析[J].国际检验医学杂志,2017,38(7):969-971.
[10]朱庆义.妇产科常见感染性疾病的病原学研究现状[J/OL].中华临床实验室管理电子杂志,2016,4(4):213-218.
[11]陈晓星.100例不孕患者解脲支原体培养及其药敏分析[J].中国优生与遗传杂志,2005,13(3):110.
[12]黄朝霞,涂权梅,王荣跃,等.女性不孕症患者支原体感染情况及耐药分析[J].中国妇幼保健,2007,22(14):1952-1953.
[13]裴丽君,王亚菲,郭超,等.妇女生殖道解脲支原体感染与自然流产关联的meta分析[J].中国计划生育学杂志,2012,20(7):449-454.
[14]陈曦,刘朝晖.生殖道沙眼衣原体感染的流行病学现状[J].中国性科学,2016,25(1):95-97.
[15]周侃,魏瑜,周迪.417例女性生殖道感染沙眼衣原体和解脲支原体检测结果分析[J].国际检验医学杂志,2017,38(7):969-971.
[16]董晓娟,何婵凤,王妍,等.孕妇生殖道沙眼衣原体与解脲脲支原体感染对胚胎停育的影响分析[J].中华医院感染学杂志,2016,26(8):1868-1870.
[17]Centers for disease control and prevention.2015 sexually transmitted diseases surveillance[J/CD].Available online at:https://wwwcdcgov/std/stats15/chlamydiahtm foot 2.(accessed at February 8,2017).
[18]岳晓丽,龚向东,滕菲,等2008-2015年中国性病监测点生殖道沙眼衣原体感染流行特征分析[J].中华皮肤科杂志,2016,49(5):308-313.
[19]Herzog S A,Heijne J C,Althaus C L,et al.Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease:systematic review of mathematical modeling studies[J].Sex Transm Dis,2012,39(8):628-637.
[20]2010年原卫生部办公厅关于印发《医疗机构临床基因扩增检验实验室管理办法》的通知(卫办医政发[2010]194号)[S].
[2]周丽华,沈梦远,李曦,等.12548例泌尿生殖道标本解脲尿原体和人型支原体检测及药物敏感性分析[J].中国卫生检验杂志,2018(1):120-125.
[3]韩泽平,林学良,何金花,等.广州市番禺区五种性传播疾病的流行病学分析[J].中国优生与遗传杂志,2016(8):18-20.
[4]Handsfield H H.Sexually Transmitted Diseases,Infections,and Disorders:What’s in a Name[J].Sexually Transmitted Diseases,2015,42(4):169.
[5]任翊,刘朝晖,朱学骏.妇科门诊人群宫颈解脲支原体检出情况及分群分型[J].中国皮肤性病学杂志,2002,16(3):155-157.
[6]张帝开,李秀云,覃春容,等.健康妇女下生殖道解脲脲原体及其分群分型研究[J].中国微生态学杂志,2007,19(3):288-289,292.
[7]Mindel A,Dwyer D,Herring B,et al.Global Epidemiology of Sexually Transmitted Diseases[J].Elsevier Ltd,2013,351 Suppl3(1):3-43.
[8]张欠欠,仵恒立,胡军婷,等.荧光定量PCR检测淋球菌、沙眼衣原体和解脲脲原体结果分析[J].中国人兽共患病学报,2016,32(3):312-314.
[9]周侃,魏瑜,周迪.417例女性生殖道感染沙眼衣原体和解脲支原体检测结果分析[J].国际检验医学杂志,2017,38(7):969-971.
[10]朱庆义.妇产科常见感染性疾病的病原学研究现状[J/OL].中华临床实验室管理电子杂志,2016,4(4):213-218.
[11]陈晓星.100例不孕患者解脲支原体培养及其药敏分析[J].中国优生与遗传杂志,2005,13(3):110.
[12]黄朝霞,涂权梅,王荣跃,等.女性不孕症患者支原体感染情况及耐药分析[J].中国妇幼保健,2007,22(14):1952-1953.
[13]裴丽君,王亚菲,郭超,等.妇女生殖道解脲支原体感染与自然流产关联的meta分析[J].中国计划生育学杂志,2012,20(7):449-454.
[14]陈曦,刘朝晖.生殖道沙眼衣原体感染的流行病学现状[J].中国性科学,2016,25(1):95-97.
[15]周侃,魏瑜,周迪.417例女性生殖道感染沙眼衣原体和解脲支原体检测结果分析[J].国际检验医学杂志,2017,38(7):969-971.
[16]董晓娟,何婵凤,王妍,等.孕妇生殖道沙眼衣原体与解脲脲支原体感染对胚胎停育的影响分析[J].中华医院感染学杂志,2016,26(8):1868-1870.
[17]Centers for disease control and prevention.2015 sexually transmitted diseases surveillance[J/CD].Available online at:https://wwwcdcgov/std/stats15/chlamydiahtm foot 2.(accessed at February 8,2017).
[18]岳晓丽,龚向东,滕菲,等2008-2015年中国性病监测点生殖道沙眼衣原体感染流行特征分析[J].中华皮肤科杂志,2016,49(5):308-313.
[19]Herzog S A,Heijne J C,Althaus C L,et al.Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease:systematic review of mathematical modeling studies[J].Sex Transm Dis,2012,39(8):628-637.
[20]2010年原卫生部办公厅关于印发《医疗机构临床基因扩增检验实验室管理办法》的通知(卫办医政发[2010]194号)[S].