烟用酒精中羰基化合物的快速高效分离
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摘要
本文将超高效液相色谱等度洗脱(Ultra performance liquid chromatography-isocratic elution,UPLC-IE)法用于分离烟用酒精提取物中的8种羰基化合物。通过优化分离条件,可利用UPLC-IE法从烟用酒精提取物中分离得到6种羰基化合物(甲醛,乙醛,丙酮,丙烯醛,丙醛,巴豆醛)。
In this work,UPLC-IE method was used to separate eight carbonyl compounds in tobacco alcohol. By optimizing the separation conditions,UPLC-IE can be used to separate 6 kinds of carbonyl compounds from tobacco alcohol(formaldehyde,acetaldehyde,acetone,acrolein,propionaldehyde,crotonylaldehyde),while traditional high performance liquid chromatography(HPLC)can only be extracted from tobacco alcohol two carbonyl compounds(acetaldehyde,acrolein)were isolated.
In this work,UPLC-IE method was used to separate eight carbonyl compounds in tobacco alcohol. By optimizing the separation conditions,UPLC-IE can be used to separate 6 kinds of carbonyl compounds from tobacco alcohol(formaldehyde,acetaldehyde,acetone,acrolein,propionaldehyde,crotonylaldehyde),while traditional high performance liquid chromatography(HPLC)can only be extracted from tobacco alcohol two carbonyl compounds(acetaldehyde,acrolein)were isolated.
引文
[1] Wyder E L,Hoffman D,Tobacco and Tobacco smoke[M].Academic Press,1967.
[2] Hoffmann D,Hoffmann I,E1-bayoumy K. The less harmful cigarette:a controversial issue. Attribute to Ernst L. Wynder[J]. Chem. Res. Toxicol.,2001,14:767-790.
[3]秦存永,何爱民,赵晖,郑松锦,张晓静,The Determination of Distribution on Major Carbonyl Compounds during Caretigte Burning by HPLC The Food Industry(食品工业)[J],2017,01:289-292.
[4]王超,黄飞,王艳丽,孙明,姜莹,李河霖),Analysis of8 Carbonyl Compound in Smokeless Tobacco Products and Cigarette Filler by UPLC-IE Method The Food Industry(食品工业)[J],2017,03(38):256-261.
[5]张洪非,侯宏卫,庞永强.溶液捕集-高效液相色谱法测定卷烟主流烟气中主要羰基化合物. Physical Testing and Chemical Analysis Part B:Chemical Analysis(理化检验-化学分册)[J],2013,49:19-22.
[6] Wu Jingcun,William S. Rickert,Andrew Masters. An improved high performance liquid chromatography-fluorescence detection method for the analysis of major phenolic compounds in cigarette smoke and smokeless tobacco products[J]. Journal of Chromatography A,2012,1264:40-47.
[7]徐寿昌.有机化学.北京:高等教育出版社,1993,283.
[8] Miller J H,Gardner W P,Gonzalez R R. UHPLC Separation with MS analysis for eight carbonyl compounds in mainstream tobacco smoke[J]. J. Chromatogr. Sci.,2010,48(1):12-17.
[9]王鹏,尚军,吕祥敏,黎洪利,彭忠,流动分析法测定烟草中的羰基化合物含量[J].重庆与世界(学术版). 2016,04(11):15-18.
[10]余晶晶,王昇,王冰,赵晓东,蔡君兰,颜权平,潘立宁,谢复炜,张晓兵,Determination of Eight Volatile Carbonyl Compounds in Cigarette Filter by LC-ESI-MS/MS Tobacco Science&Technology(烟草科技)[J] 2013,09:39-46.
[11]陈小龙,高旭,李宏伟,丙烯醛分析检测技术研究[J].甘肃科技,2015,31(23):43-45.
[12]吴帅宾,李中皓,张洪非,韩书磊,刘彤,陈欢,An Ultra Performance Liquid Chromatography-Isocratic Elution Method for the Rapid and Efficient Separation of 8 Carbonyl Compounds in Tobacco Mainstream Smoke Journal of Analytical Science[J]分析科学学报,2014,03(30):357-360.
[13] YC/T 254-2008.卷烟主流烟气中主要羰基化合物的测定高效液相色谱法[S].
[2] Hoffmann D,Hoffmann I,E1-bayoumy K. The less harmful cigarette:a controversial issue. Attribute to Ernst L. Wynder[J]. Chem. Res. Toxicol.,2001,14:767-790.
[3]秦存永,何爱民,赵晖,郑松锦,张晓静,The Determination of Distribution on Major Carbonyl Compounds during Caretigte Burning by HPLC The Food Industry(食品工业)[J],2017,01:289-292.
[4]王超,黄飞,王艳丽,孙明,姜莹,李河霖),Analysis of8 Carbonyl Compound in Smokeless Tobacco Products and Cigarette Filler by UPLC-IE Method The Food Industry(食品工业)[J],2017,03(38):256-261.
[5]张洪非,侯宏卫,庞永强.溶液捕集-高效液相色谱法测定卷烟主流烟气中主要羰基化合物. Physical Testing and Chemical Analysis Part B:Chemical Analysis(理化检验-化学分册)[J],2013,49:19-22.
[6] Wu Jingcun,William S. Rickert,Andrew Masters. An improved high performance liquid chromatography-fluorescence detection method for the analysis of major phenolic compounds in cigarette smoke and smokeless tobacco products[J]. Journal of Chromatography A,2012,1264:40-47.
[7]徐寿昌.有机化学.北京:高等教育出版社,1993,283.
[8] Miller J H,Gardner W P,Gonzalez R R. UHPLC Separation with MS analysis for eight carbonyl compounds in mainstream tobacco smoke[J]. J. Chromatogr. Sci.,2010,48(1):12-17.
[9]王鹏,尚军,吕祥敏,黎洪利,彭忠,流动分析法测定烟草中的羰基化合物含量[J].重庆与世界(学术版). 2016,04(11):15-18.
[10]余晶晶,王昇,王冰,赵晓东,蔡君兰,颜权平,潘立宁,谢复炜,张晓兵,Determination of Eight Volatile Carbonyl Compounds in Cigarette Filter by LC-ESI-MS/MS Tobacco Science&Technology(烟草科技)[J] 2013,09:39-46.
[11]陈小龙,高旭,李宏伟,丙烯醛分析检测技术研究[J].甘肃科技,2015,31(23):43-45.
[12]吴帅宾,李中皓,张洪非,韩书磊,刘彤,陈欢,An Ultra Performance Liquid Chromatography-Isocratic Elution Method for the Rapid and Efficient Separation of 8 Carbonyl Compounds in Tobacco Mainstream Smoke Journal of Analytical Science[J]分析科学学报,2014,03(30):357-360.
[13] YC/T 254-2008.卷烟主流烟气中主要羰基化合物的测定高效液相色谱法[S].