探讨对围绝经期功能失调性子宫出血应用孕激素治疗的临床疗效
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摘要
目的探讨对围绝经期功能失调性子宫出血应用孕激素治疗的临床疗效。方法选取本院2014年7月至2016年7月收治的60例围绝经期功能失调性子宫出血患者作为研究对象,随机分为观察组和对照组,每组各30例。对观察组应用孕激素安宫黄体酮进行治疗,对对照组应用米非司酮进行治疗,两组患者均给予刮宫手术,观察两组患者临床治疗效果,统计两组患者治疗期间的不良反应例数及出血例数和患者子宫内膜厚度。结果两组患者子宫内膜厚度均有所减少,观察组治疗后子宫内膜厚度大于对照组,差异有统计学意义(P<0.05)。观察组患者治疗有效率为74.23%,对照组治疗有效率为97.29%,观察组治疗有效率明显低于对照组,P<0.05,差异具有显著的统计学意义。结论孕激素安宫黄体酮治疗围绝经期功能失血性子宫出血具有较显著的效果,可以有效减少子宫内膜厚度,但不如米非司酮的临床疗效好。
Objective To explore application of perimenopausal dysfunctional uterine bleeding progesterone clinical curative effect of treatment. Methods Selected 60 cases of perimenopausal dysfunctional uterine bleeding had been treated by our hospital during from July 2014 to July 2016 as the research object, randomly divided into observation group and control group, and 30 cases in each group. Using progesterone provera to treat the observation group, and using mifepristone to treat the control group, two groups of patients were given curettage surgery, observed clinical therapeutic effect in both groups, statisticed of two groups of patients with bleeding during treatment of adverse reaction cases and hemorrhage cases, and the endometrial thickness of patients. Results Two groups of patients with endometrial thickness decreased, observation group of endometrial thickness is greater than the control group after treatment, the difference was statistically significant(P<0.05). The observation group of patients treatment effective rate was 74.23%, the control group treatment effective rate of 97.29%, the treatment efficient observation group was obviously lower than the control group, P<0.05, the difference was statistically significant. Conclusion Progesterone provera treatment of perimenopausal functional uncontrolled hemorrhagic uterine bleeding has a significant effect, can effectively reduce the endometrial thickness, but not as good as the clinical efficacy of mifepristone.
Objective To explore application of perimenopausal dysfunctional uterine bleeding progesterone clinical curative effect of treatment. Methods Selected 60 cases of perimenopausal dysfunctional uterine bleeding had been treated by our hospital during from July 2014 to July 2016 as the research object, randomly divided into observation group and control group, and 30 cases in each group. Using progesterone provera to treat the observation group, and using mifepristone to treat the control group, two groups of patients were given curettage surgery, observed clinical therapeutic effect in both groups, statisticed of two groups of patients with bleeding during treatment of adverse reaction cases and hemorrhage cases, and the endometrial thickness of patients. Results Two groups of patients with endometrial thickness decreased, observation group of endometrial thickness is greater than the control group after treatment, the difference was statistically significant(P<0.05). The observation group of patients treatment effective rate was 74.23%, the control group treatment effective rate of 97.29%, the treatment efficient observation group was obviously lower than the control group, P<0.05, the difference was statistically significant. Conclusion Progesterone provera treatment of perimenopausal functional uncontrolled hemorrhagic uterine bleeding has a significant effect, can effectively reduce the endometrial thickness, but not as good as the clinical efficacy of mifepristone.
引文
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[2]王莲红.子宫出血易忽略因素的临床分析[J].基层医学论坛,2006,10(16):699-700.
[3]辛春.围绝经期功能失调性子宫出血孕激素治疗疗效观察[J].河北医药,2012,34(6):877-878.
[4]李杨,朱婷.孕激素治疗围绝经期功能失调性子宫出血的效果观察[J].中国医学创新,2014(01):65-66.
[5]黄剑云.安宫黄体酮联合抗生素治疗子宫内膜炎的效果观察[J].基层医学论坛,2016,9(22):65-66.
[6]吴晓燕.安宫黄体酮辅助刮宫术治疗围绝经期功能失调性子宫出血的效果观察[J].临床合理用药杂志,2014(27):95-96.
[7]辛春.围绝经期功能失调性子宫出血孕激素治疗疗效观察[J].河北医药,2012,34(6):877-878.
[8]张雅静.子宫内膜厚度对激素治疗围绝经期功血的价值[J].中外医学研究,2016,14(30):146-148.
[9]沈景丰,赵玲萍,蒋盈盈.米非司酮对围绝经期功血患者诱导闭经的效果[J].中国临床药学杂志,2009(2):93-95.
[10]项燕.小剂量米非司酮联合去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血的疗效分析[J].中国现代药物应用,2015(3):142-143.
[11]智桂红.米非司酮治疗围绝经期功能失调性子宫出血的临床分析[J].中国卫生标准管理,2014(20):107-109.
[12]徐国稚,梁燕梅.不同药物治疗围绝经期功能失调性子宫出血疗效观察[J].社区医学杂志,2014,12(10):28-29.