首发抑郁症患者脑血流灌注和脑微观结构改变磁共振三维动脉自旋标记及弥散张量成像观察
摘要
目的探讨首发抑郁症患者脑血流灌注和脑微观结构改变的磁共振动脉自旋标记(ASL)及弥散张量成像(DTI表现。方法首发抑郁症患者15例(观察组),收集年龄与观察组匹配的15例体检健康志愿者作为对照组,两组患者均行ASL及DTI检查。结果两组左额叶、右额叶、左颞叶、右颞叶、左顶叶、左基底节区及右基底节区局部脑血流量值差异均有统计学意义(均<0.05)。两组各脑区弥散系数值差异均无统计学意义(均> 0.05),右侧额叶、左侧额叶、胼胝体膝部及胼胝体压部各向异性分数值差异均有统计学意义(均<0.05)。结论 ASL和DTI可反映首发抑郁症脑血管灌注的改变和脑微观结构的异常,有助于解释抑郁症的发生机制,检测抑郁症脑功能的变化。
引文
[1]Vangu MD,Esser JD,Boyd IH,et al.Effects of electroconvulsive therapy on regional cerebral blood flow measured by99mte chnetium HMPAO SPECT[J].Progress in Neuro-Psychopharmacology&Biological Psychiatry,2003,27(1):15.
[2]Videbech P.PET measurements of brain glucose metabolism and blood flow in major depressive disorder:A critical review[J].Acta Psychiatr Scand,2000,101(1):11-20.
[3]Fountoulakis KN,lacovides A,Geraimou G,et al.The relationship of regional cerebral blood flow with subtupes of major depression[J].Prog Neuropsychopharmacol Biol Psychiatry,2004,28(3):537-546.
[4]赵晋华,林祥通,江开达,等.抑郁症的基础与认知激活脑SPECT显像[J].中华核医学杂志,1998,18(2):70.
[5]吕粟,黄晓琦,孙学礼,等.抑郁症患者脑MR血流灌注的图像特征[J].中华放射学杂志,2009,43(3):244-248.
[6]Basser PJ,Pierpaoli C.Microstructural and physiological leatures of tissues elucidated by quantitative-diffusion-tensor MRI[J].J Magn Reson B,1996,111(3):209-219.
[7]Aghajani M,Veer IM,Lang ND,et al.Altered white-matte architecture in treatmentnaive adolescents with clinical depression[J].Psychol Med,2014,44(11):2287-2298.
[8]孙自豪,薛志敏,章瑜,等.未经治疗的抑郁症首次发病患者脑弥散张量成像的研究[J].中华精神科杂志,2009,42(4):198-201.
[2]Videbech P.PET measurements of brain glucose metabolism and blood flow in major depressive disorder:A critical review[J].Acta Psychiatr Scand,2000,101(1):11-20.
[3]Fountoulakis KN,lacovides A,Geraimou G,et al.The relationship of regional cerebral blood flow with subtupes of major depression[J].Prog Neuropsychopharmacol Biol Psychiatry,2004,28(3):537-546.
[4]赵晋华,林祥通,江开达,等.抑郁症的基础与认知激活脑SPECT显像[J].中华核医学杂志,1998,18(2):70.
[5]吕粟,黄晓琦,孙学礼,等.抑郁症患者脑MR血流灌注的图像特征[J].中华放射学杂志,2009,43(3):244-248.
[6]Basser PJ,Pierpaoli C.Microstructural and physiological leatures of tissues elucidated by quantitative-diffusion-tensor MRI[J].J Magn Reson B,1996,111(3):209-219.
[7]Aghajani M,Veer IM,Lang ND,et al.Altered white-matte architecture in treatmentnaive adolescents with clinical depression[J].Psychol Med,2014,44(11):2287-2298.
[8]孙自豪,薛志敏,章瑜,等.未经治疗的抑郁症首次发病患者脑弥散张量成像的研究[J].中华精神科杂志,2009,42(4):198-201.