重症急性胰腺炎患者应用微生态肠内营养支持治疗的效果
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摘要
目的探究重症急性胰腺炎(SAP)患者应用微生态肠内营养(EIN)支持治疗的效果。方法选取我院收治的64例SAP患者为研究对象,随机分为观察组和对照组,每组32例。观察组患者给予EIN支持治疗,对照组患者给予肠内要素营养治疗。记录两组患者症状缓解时间差异,比较两组临床效果。结果观察组患者相关症状缓解时间均比对照组短(P<0.05);治疗7 d后,两组患者CD3~+、CD4~+/CD8~+水平均较治疗前显著升高,LPS、D-乳酸水平则较治疗前降低,且观察组上述指标水平均优于对照组(P<0.05)。结论 EIN应用于SAP患者治疗中效果较好,可促进患者症状缓解,且能改善其肠黏膜损伤状况,于提高患者免疫功能也有积极意义。
Objective To explore the effect of enteral ecoimmunonutrition(EIN) support in patients with severe acute pancreatitis(SAP). Methods A total of 64 cases of SAP patients in our hospital were selected and randomly divided into observation group and control group, with 32 cases in each group. The observation group was given EIN support, and the control group was treated with enteral nutrition(EN). The differences of the relief time of symptoms were recorded and the clinical effects were compared between the two groups. Results The relief time of related symptoms in the observation group were shorter than those in the control group(P<0.05). After 7 d of treatment, the levels of CD3~+, CD4~+/CD8~+in the two groups significantly increased, while the levels of LPS and D-lactate decreased, and those in the observation group were better than the control group(P<0.05). Conclusion EIN for SAP patients has good treatment effects, and it can improve the symptoms relief, the damage of intestinal mucosa and the immune function.
Objective To explore the effect of enteral ecoimmunonutrition(EIN) support in patients with severe acute pancreatitis(SAP). Methods A total of 64 cases of SAP patients in our hospital were selected and randomly divided into observation group and control group, with 32 cases in each group. The observation group was given EIN support, and the control group was treated with enteral nutrition(EN). The differences of the relief time of symptoms were recorded and the clinical effects were compared between the two groups. Results The relief time of related symptoms in the observation group were shorter than those in the control group(P<0.05). After 7 d of treatment, the levels of CD3~+, CD4~+/CD8~+in the two groups significantly increased, while the levels of LPS and D-lactate decreased, and those in the observation group were better than the control group(P<0.05). Conclusion EIN for SAP patients has good treatment effects, and it can improve the symptoms relief, the damage of intestinal mucosa and the immune function.
引文
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[6]王庆华,管清海,商琼琼,等.免疫肠内营养对重症急性胰腺炎病人肠黏膜屏障和细胞因子的影响[J].肠外与肠内营养,2016,23(5):275-278.
[7]张著杰,张振名,赵晓晨.不同配方肠内营养支持对重症急性胰腺炎患者应用效果比较[J].中国普通外科杂志,2016,25(3):339-344.
[2]黄强业,粱开坚,王齐全,等.肠内营养+双歧杆菌三联活菌散对重症急性胰腺炎患者疗效的影响[J].现代消化及介入诊疗,2015,20(6):663-665.
[3]中华医学会外科学分会胰腺外科学组.重症急性胰腺炎诊治指南[J].中华外科杂志,2007,45(11):727-729.
[4]杜宗汉,王文强,陈龙,等.经鼻胃管肠内营养在重症急性胰腺炎病人的应用[J].肠外与肠内营养,2015,22(3):168-170.
[5]殷景远,单红艳,李亚岭,等.酪酸梭菌活菌散联合肠内营养在重症急性胰腺炎治疗中的应用[J].广东医学,2015,36(3):464-466.
[6]王庆华,管清海,商琼琼,等.免疫肠内营养对重症急性胰腺炎病人肠黏膜屏障和细胞因子的影响[J].肠外与肠内营养,2016,23(5):275-278.
[7]张著杰,张振名,赵晓晨.不同配方肠内营养支持对重症急性胰腺炎患者应用效果比较[J].中国普通外科杂志,2016,25(3):339-344.