骆驼锥虫病研究现状
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摘要
锥虫病是世界卫生组织认定的由锥虫引发的主要的人畜共患原虫病之一。在我国流行的主要是骆驼、马、牛等家畜的伊氏锥虫病。骆驼锥虫病可造成骆驼日渐消瘦、心肌衰竭甚至死亡,随着疾病的蔓延会造成较大的经济损失。通常使用苏拉明、贝尼尔、安锥赛等药物可达到防治该病的目的。为了让更多的人们较为系统地了解和有效防治骆驼锥虫病,从骆驼锥虫病的病原体特征、流行病学、临床症状、病理变化和防治措施等方面进行了综述。此外,对骆驼锥虫病的防治提出了新的方法和思路,为骆驼锥虫病的诊断、治疗及预防提供参考。
Trypanosomiasis,certified by WHO,is one of the critical zoonosis caused by trypanosomes.Trypanosoma evansi,which infects camels,horses,cattle and other domestic animals,is widely prevalent in China.Camel trypanosomiasis can cause livestock to lose weight,cardiac dysfunction and even death,resulting in greater economic loss as the diseases spread.Suramin,Berenil,Antrycide and other drugs are generally used for effective prophylaxis and treatment of this disease.In order to make more people widely understand and effectively control the camel trypanosomiasis,the pathogen characteristics,epidemiology,clinical symptoms,pathological lesions,prevention and treatment measures of camel trypanosomiasis were comprehensively discussed.Furthermore,the new methods and ideas were mentioned for prophylaxis and treatment of camel trypanosomiasis in the future,in order to strive for achieving a significant progress in diagnosis,treatment and prophylaxis of camel trypanosomiasis.
Trypanosomiasis,certified by WHO,is one of the critical zoonosis caused by trypanosomes.Trypanosoma evansi,which infects camels,horses,cattle and other domestic animals,is widely prevalent in China.Camel trypanosomiasis can cause livestock to lose weight,cardiac dysfunction and even death,resulting in greater economic loss as the diseases spread.Suramin,Berenil,Antrycide and other drugs are generally used for effective prophylaxis and treatment of this disease.In order to make more people widely understand and effectively control the camel trypanosomiasis,the pathogen characteristics,epidemiology,clinical symptoms,pathological lesions,prevention and treatment measures of camel trypanosomiasis were comprehensively discussed.Furthermore,the new methods and ideas were mentioned for prophylaxis and treatment of camel trypanosomiasis in the future,in order to strive for achieving a significant progress in diagnosis,treatment and prophylaxis of camel trypanosomiasis.
引文
[1] Ngaira J M,Bett B,Karanja S M,et al.Evaluation of antigen and antibody rapid detection tests for Trypanosoma evansi infection in camels in Kenya[J].Vet Parasitol,2003,114(2):131-141.
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[3] Desquesnes M,Holzmuller P,Lai D H,et al.Trypanosoma evansi and Surra:a review and perspectives on origin,history,distribution,taxonomy,morphology,hosts,and pathogenic effects[J].Biomed Res Int,doi:10.1155/2013/194176.
[4] Bennoune O,Adili N,Amri K,et al.Trypanosomiasis of camels (Camelus dromedarius) in Algeria:first report[J].Vet Res Forum,2013,4(4):273-275.
[5] 李详瑞.我国伊氏锥虫病的研究现状及存在的主要问题[J].畜牧与兽医,1994(4):183-185.
[6] 颜喜俊,周庆国.家畜伊氏锥虫病的防治[J].中国畜牧兽医文摘,2014,30(12):134.
[7] 许明,加冷·哈布尔哈克,巴依曼·毛吾列提.骆驼伊氏锥虫病的诊治[J].畜牧兽医科技信息,2016(5):51.
[8] Khosravi A,Hakimi Parizi M,Bamorovat M,et al.Prevalence of Trypanosoma evansi in camels using molecular and parasitological methods in the southeast of Iran,2011[J].J Parasit Dis,2015,39(3):422-425.
[9] 别依勒汗.骆驼锥虫病的防治[J].中国兽医杂志,2003(3):13.
[10] Losos G J,刘钟灵.伊氏锥虫病(述评)[J].湖北农业科学,1981(10):35-38.
[11] Bezie M,Girma M,Dagnachew S,et al.African trypanosomes:virulence factors,pathogenicity and host responses[J].J Anim Vet Adv,2014,4(11):732-745.
[12] Mackinnon M J,Gandon S,Read A F.Virulence evolution in response to vaccination:the case of malaria[J].Vaccine,2008,26(3):42-52.
[13] Little T J,Chadwick W,Watt K.Parasite variation and the evolution of virulence in a Daphnia-microparasite system[J].Parasitology,2008,135(3):303-308.
[14] Kamidi C M,Auma J,Mireji P O,et al.Differential virulence of camel Trypanosoma evansi isolates in mice[J].Parasitology,2018(24):1-8.
[15] Wernery U,Kinne J,Schuster R K,et al.Camelid Infectious Disorders[M].Paris:Office International Des Eplzooties,2014:358-365.
[16] 洪清华,王韵丞,李鸿雁.一段检测锥虫特异性核酸靶序列的筛选及评价[J].中国寄生虫学与寄生虫病杂志,2017(6):588-593.
[17] Njiru Z K,Constantine C C,Guya S,et al.The use of ITS1 rDNA PCR in detecting pathogenic African trypanosomes[J].Parasitol Res,2005,95(3):186-192.
[18] 唐丽华.抗锥虫兽药及在兽医临床上的应用[J].兽医导刊,2015(24):188.
[19] 陶金林,蔡国宝,杨旭东,等.役用骆驼锥虫混合感染肺丝虫病的诊断与综合防治[J].中国草食动物科学,2015,239(3):48-49.
[20] Mossaad E,Salim B,Suganuma K,et al.Trypanosoma vivax is the second leading cause of camel trypanosomosis in Sudan after Trypanosoma evansi[J].Parasit Vectors,2017,10(1):176.
[21] 阿里木江·阿不都热西提.骆驼锥虫病的治疗预防措施[J].畜禽业,2017,28(8):134.
[22] 陈木新,陈家旭.基因芯片技术在人体锥虫生物学特性研究方面的进展[J].中国寄生虫学与寄生虫病杂志,2016,34(4):87-91.
[2] Rathore N S,Manuja A,Manuja B K,et al.Chemotherapeutic approaches against Trypanosoma evansi:retrospective analysis,current status and future outlook[J].Curr Top Med Chem,2016,16(20):2316-2327.
[3] Desquesnes M,Holzmuller P,Lai D H,et al.Trypanosoma evansi and Surra:a review and perspectives on origin,history,distribution,taxonomy,morphology,hosts,and pathogenic effects[J].Biomed Res Int,doi:10.1155/2013/194176.
[4] Bennoune O,Adili N,Amri K,et al.Trypanosomiasis of camels (Camelus dromedarius) in Algeria:first report[J].Vet Res Forum,2013,4(4):273-275.
[5] 李详瑞.我国伊氏锥虫病的研究现状及存在的主要问题[J].畜牧与兽医,1994(4):183-185.
[6] 颜喜俊,周庆国.家畜伊氏锥虫病的防治[J].中国畜牧兽医文摘,2014,30(12):134.
[7] 许明,加冷·哈布尔哈克,巴依曼·毛吾列提.骆驼伊氏锥虫病的诊治[J].畜牧兽医科技信息,2016(5):51.
[8] Khosravi A,Hakimi Parizi M,Bamorovat M,et al.Prevalence of Trypanosoma evansi in camels using molecular and parasitological methods in the southeast of Iran,2011[J].J Parasit Dis,2015,39(3):422-425.
[9] 别依勒汗.骆驼锥虫病的防治[J].中国兽医杂志,2003(3):13.
[10] Losos G J,刘钟灵.伊氏锥虫病(述评)[J].湖北农业科学,1981(10):35-38.
[11] Bezie M,Girma M,Dagnachew S,et al.African trypanosomes:virulence factors,pathogenicity and host responses[J].J Anim Vet Adv,2014,4(11):732-745.
[12] Mackinnon M J,Gandon S,Read A F.Virulence evolution in response to vaccination:the case of malaria[J].Vaccine,2008,26(3):42-52.
[13] Little T J,Chadwick W,Watt K.Parasite variation and the evolution of virulence in a Daphnia-microparasite system[J].Parasitology,2008,135(3):303-308.
[14] Kamidi C M,Auma J,Mireji P O,et al.Differential virulence of camel Trypanosoma evansi isolates in mice[J].Parasitology,2018(24):1-8.
[15] Wernery U,Kinne J,Schuster R K,et al.Camelid Infectious Disorders[M].Paris:Office International Des Eplzooties,2014:358-365.
[16] 洪清华,王韵丞,李鸿雁.一段检测锥虫特异性核酸靶序列的筛选及评价[J].中国寄生虫学与寄生虫病杂志,2017(6):588-593.
[17] Njiru Z K,Constantine C C,Guya S,et al.The use of ITS1 rDNA PCR in detecting pathogenic African trypanosomes[J].Parasitol Res,2005,95(3):186-192.
[18] 唐丽华.抗锥虫兽药及在兽医临床上的应用[J].兽医导刊,2015(24):188.
[19] 陶金林,蔡国宝,杨旭东,等.役用骆驼锥虫混合感染肺丝虫病的诊断与综合防治[J].中国草食动物科学,2015,239(3):48-49.
[20] Mossaad E,Salim B,Suganuma K,et al.Trypanosoma vivax is the second leading cause of camel trypanosomosis in Sudan after Trypanosoma evansi[J].Parasit Vectors,2017,10(1):176.
[21] 阿里木江·阿不都热西提.骆驼锥虫病的治疗预防措施[J].畜禽业,2017,28(8):134.
[22] 陈木新,陈家旭.基因芯片技术在人体锥虫生物学特性研究方面的进展[J].中国寄生虫学与寄生虫病杂志,2016,34(4):87-91.