六味地黄汤加减治疗肝肾阴虚型慢性湿疹临床观察
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摘要
目的:观察六味地黄汤加减治疗肝肾阴虚型慢性湿疹的临床疗效。方法:将200例确诊为肝肾阴虚型慢性湿疹患者,按照随机信封分配法分为观察组与对照组各100例,观察组予六味地黄汤加减治疗,对照组予西替利嗪治疗,2组均外用青鹏软膏。采用湿疹面积及严重度指数评分表(EASI)评价患者的皮损情况,比较2组EASI评分、瘙痒评分、临床疗效及复发率。结果:临床疗效总有效率观察组97.00%,对照组88.00%,差异有统计学意义(P<0.05);治疗后,观察组EASI评分、瘙痒评分均明显低于对照组,差异均有统计学意义(P<0.05);随访观察3月,复发率观察组16.9%,明显低于对照组34.9%,差异有统计学意义(P<0.05)。结论:六味地黄汤加减治疗肝肾阴虚型慢性湿疹,近远期疗效均优于西替利嗪,各项指标评分改善明显,复发率低。
Objective:To observe the clinical effect of modified Liuwei Dihuang tang for chronic eczema of yin deficiency of liver and kidney type. Methods:Divided 200 cases of patients diagnosed as chronic eczema of yin deficiency of liver and kidney type into the observation group and the control group randomly according to random envelope allocation method,100 cases in each group. The observation group received modified Liuwei Dihuang tang for treatment,while the control group was given cetirizine for treatment. Both groups received the external application of Qingpeng ointment. Evaluated skin lesions of patients by using eczema area and severity index rating scale(EASI),and compared EASI score,itching score,clinical effect and recurrence rate in two groups. Results:The total effective rate of clinical effect was 97.00% in the observation group and 88.00% in the control group,difference being significant(P < 0.05). After treatment,EASI score and itching score in the observation group were obviously lower than those in the control group, differences being significant(P < 0.05). After follow-up of 3 months,recurrence rate in the observation group was 16.9%,being evidently lower than 34.9% in the control group,difference being significant(P < 0.05). Conclusion:The short-and long-term clinical effect of modified Liuwei Dihuang tang for chronic eczema of yin deficiency of liver and kidney type is better than Cetirizine. Each index score improves significantly,and the recurrence rate is low.
Objective:To observe the clinical effect of modified Liuwei Dihuang tang for chronic eczema of yin deficiency of liver and kidney type. Methods:Divided 200 cases of patients diagnosed as chronic eczema of yin deficiency of liver and kidney type into the observation group and the control group randomly according to random envelope allocation method,100 cases in each group. The observation group received modified Liuwei Dihuang tang for treatment,while the control group was given cetirizine for treatment. Both groups received the external application of Qingpeng ointment. Evaluated skin lesions of patients by using eczema area and severity index rating scale(EASI),and compared EASI score,itching score,clinical effect and recurrence rate in two groups. Results:The total effective rate of clinical effect was 97.00% in the observation group and 88.00% in the control group,difference being significant(P < 0.05). After treatment,EASI score and itching score in the observation group were obviously lower than those in the control group, differences being significant(P < 0.05). After follow-up of 3 months,recurrence rate in the observation group was 16.9%,being evidently lower than 34.9% in the control group,difference being significant(P < 0.05). Conclusion:The short-and long-term clinical effect of modified Liuwei Dihuang tang for chronic eczema of yin deficiency of liver and kidney type is better than Cetirizine. Each index score improves significantly,and the recurrence rate is low.
引文
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[2]施建新,阂仲生.慢性湿疹外治法研究进展[J].河南中医,2014,34(6):1204.
[3]张冰凌.苦参等中药在皮炎湿疹类皮肤病治疗中的应用[J].中医临床研究,2013,5(10):87-88.
[4]李曙东.黄连解毒汤合消风散治疗湿热型湿疹43例疗效观察[J].湖南中医杂志,2014,30(7):87.
[5]汪海珍,杨志波.湿疹纳米乳膏联合四物消风饮治疗慢性局限性湿疹55例临床观察[J].中医药导报,2013,19(1):34-36.
[6]唐凯.四物消风散联合局部封闭治疗慢性肛门湿疹血虚风燥证的临床观察[D].长沙:湖南中医药大学,2015.
[7]孙晓晖.消风散治疗风热型湿疹临床疗效观察[J].湖北中医药大学学报,2015,17(5):83-85.
[8]崔壤仁,黄尧洲.加味龙牡二妙汤治疗湿疹的临床疗效观察[J].世界中西医结合杂志,2014,9(4):419-421.
[9]汪文.中西医结合治疗慢性湿疹68例疗效观察[J].河北中医,2012,34(9):1373-1440.
[10]唐小荣.中医辨证治疗湿疹的临床观察[J].临床合理用药,2015,8(1C):118-119.