有氧运动和抗阻运动对心衰大鼠心功能的影响
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摘要
目的观察有氧运动、抗阻运动对心衰大鼠心功能的影响。方法 60只SD大鼠随机选取8只作为对照组,其余52只皮下注射异丙肾上腺素建立心衰模型。造模成功后,将造模存活大鼠随机分为模型组、有氧运动组、抗阻运动组、有氧运动联合抗阻运动组,每组12只。每组按不同的运动方案进行8周后用Elisa法检测NT-proBNP指标,并计算大鼠的HMI指数。结果对照组、模型组、有氧运动组、抗阻运动组、有氧运动联合抗阻运动组的HMI指数依次为(2.44±0.23)mg/g、(3.53±0.21)mg/g、(3.11±0.23)mg/g、(3.07±0.20)mg/g、(2.86±0.15)mg/g,NT-proBNP指数依次为(96.39±18.76)pg/mL、(445.65±34.17)pg/mL、(341.22±23.23)pg/mL、(333.82±17.64)pg/mL、(290.68±14.99)pg/mL;有氧运动组、抗阻运动组、有氧运动联合抗阻运动组均可明显降低心衰大鼠的NT-proBNP、HMI指数,与模型组比较有统计学意义(P<0.01);且与有氧运动组、抗阻运动组相比,有氧运动联合抗阻运动组效果更显著(P<0.05),但有氧运动组和抗阻运动组相比疗效无显著差异(P>0.05)。结论有氧运动、抗阻运动均可改善心衰,且有氧运动联合抗阻运动改善心衰的效果更显著。
Objective To observe effect of aerobic exercise training and resistance exercise training on cardiac function in rats with heart failure. Methods Eight rats were randomly selected from 60 SD rats as the control group, and the others were built for the cardiomyopathy model by subcutaneous injection of isoprenaline. After successful modeling, the model group was randomly divided into the model group, the aerobic exercise training group, the resistance exercise training group, and the aerobic exercise training combined with the resistance exercise training group, with 12 rats in each group. After 8 weeks experiment, NT-proBNP index was detected by Elisa method, and the HMI of rats was calculated. Results The HMI index of the control group, the model group, the aerobic exercise group, the resistance exercise group, and the aerobic exercise combined resistance exercise group were(2.44±0.23) mg/g,(3.53±0.21)mg/g,(3.11±0.23) mg/g,(3.07±0.20) mg/g,(2.86±0.15) mg/g, respectively. And NT-proBNP index of these groups was(96.39±18.76)pg/mL,(445.65±34.17) pg/mL,(341.22±23.23) pg/mL,(333.82±17.64) pg/mL,(290.68±14.99) pg/mL. The aerobic exercise group, the resistance exercise group, and the aerobic exercise combined with the resistance exercise group could significantly reduce NT-proBNP and HMI index in rats with heart failure, which had statistically significant difference with the data in the model group(P <0.01).Compared with the aerobic exercise group, the anti-resistance exercise group, the effect of aerobic exercise combined with the antiresistance exercise group was more obvious(P<0.05). And the difference between the aerobic exercise group and the anti-resistance exercise group was not significant(P>0.05). Conclusion The aerobic exercise training and the resistance exercise training can reduce the level of NT-proBNP and HMI, which has a good effect on heart failure. And the effect of aerobic exercise combined with resistance exercise training is more obvious.
Objective To observe effect of aerobic exercise training and resistance exercise training on cardiac function in rats with heart failure. Methods Eight rats were randomly selected from 60 SD rats as the control group, and the others were built for the cardiomyopathy model by subcutaneous injection of isoprenaline. After successful modeling, the model group was randomly divided into the model group, the aerobic exercise training group, the resistance exercise training group, and the aerobic exercise training combined with the resistance exercise training group, with 12 rats in each group. After 8 weeks experiment, NT-proBNP index was detected by Elisa method, and the HMI of rats was calculated. Results The HMI index of the control group, the model group, the aerobic exercise group, the resistance exercise group, and the aerobic exercise combined resistance exercise group were(2.44±0.23) mg/g,(3.53±0.21)mg/g,(3.11±0.23) mg/g,(3.07±0.20) mg/g,(2.86±0.15) mg/g, respectively. And NT-proBNP index of these groups was(96.39±18.76)pg/mL,(445.65±34.17) pg/mL,(341.22±23.23) pg/mL,(333.82±17.64) pg/mL,(290.68±14.99) pg/mL. The aerobic exercise group, the resistance exercise group, and the aerobic exercise combined with the resistance exercise group could significantly reduce NT-proBNP and HMI index in rats with heart failure, which had statistically significant difference with the data in the model group(P <0.01).Compared with the aerobic exercise group, the anti-resistance exercise group, the effect of aerobic exercise combined with the antiresistance exercise group was more obvious(P<0.05). And the difference between the aerobic exercise group and the anti-resistance exercise group was not significant(P>0.05). Conclusion The aerobic exercise training and the resistance exercise training can reduce the level of NT-proBNP and HMI, which has a good effect on heart failure. And the effect of aerobic exercise combined with resistance exercise training is more obvious.
引文
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[12]武俊英,孟世峰,许志强,等.心力衰竭病人运动康复治疗的系统评价[J].中西医结合心脑血管病杂志,2017,15(18):2232-2236.
[13]李伟,沈维艳,长期有氧运动联合抗阻训练对冠心病致心肌缺血患者心功能和运动耐力及生活质量的影响研究[J].医药,2016(5):229-230.
[14]黄兴清.抗阻运动在冠心病心力衰竭治疗中的应用研究[J]中国循证心血管医学杂志,2017,9(2):203-205.
[2]Renxin J I,Chen W,Qi Q I.Summary of Proprioceptive Training on Motor Dysfunction Rehabilitation[J].Rehabilitation Medicine,2017,27(2):53-55.
[3]丁立群,张云梅,张进,等.运动康复治疗对射血分数保存心力衰竭患者运动耐力、舒张功能和生活质量的影响[J]临床心血管病杂志,2017,33(9):33-37.
[4]Weigand K,Witte R,Moukabary T,et al.In-vivo Electrophysiological Study of Induced Ventricular Tachycardia in Intact Rat Model of Chronic Ischemic Heart Failure.[J]IEEE Transactions on Biomedical Engineering,2017,64(6)1393-1399.
[5]Li D,Li Q L,Ma Q,et al.[Effects of Moxibustion on Ventricular Mass Index and Expression of Apoptosis Related Proteins in Myocardium of Rats with Chronic Heart Failure][J].Zhen ci yan jiu=Acupuncture research,2018,43(2)80-82.
[6]LI P,LUO S,PAN C.et al.Modulation of fatty acid metabolism is involved in the alleviation of isoproterenolinduced rat heart failure by fenofibrate[J].Molecular Mddicine Reports,2015,12(6):7899-7906.
[7]倪华,袁勇,徐文津,等.有氧运动联合弹性运动治疗冠心病合并心功能不全患者疗效观察[J].世界最新医学信息文摘,2018,18(69):110-111.
[8]唐强,尹侠,朱路文,等.慢性心力衰竭患者运动康复研究进展[J].康复学报,2018,28(5):65-70.
[9]尚佳,王伟,吴昊.有氧运动对2型糖尿病心力衰竭患者心功能的影响[J].临床医学工程,2017,24(10):1381-1382.
[10]杨静,李钰兰,贾百全,等.芪苈强心胶囊联合左西孟旦治疗充血性心力衰竭的疗效及对血清NT-proBNP、Hcy水平的影响[J].药物评价研究,2017,40(8):1122-1125.
[11]Hornfeldt C S.Growing evidence of the beneficial effects of a marine protein‐based dietary supplement for treating hair loss[J].J Cosmet Dermatol,2017,17(2):209-213.
[12]武俊英,孟世峰,许志强,等.心力衰竭病人运动康复治疗的系统评价[J].中西医结合心脑血管病杂志,2017,15(18):2232-2236.
[13]李伟,沈维艳,长期有氧运动联合抗阻训练对冠心病致心肌缺血患者心功能和运动耐力及生活质量的影响研究[J].医药,2016(5):229-230.
[14]黄兴清.抗阻运动在冠心病心力衰竭治疗中的应用研究[J]中国循证心血管医学杂志,2017,9(2):203-205.