不同剂量戊酸雌二醇对宫内组织残留的治疗探讨
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摘要
目的探讨不同剂量戊酸雌二醇在宫内组织残留临床治疗中的应用效果。方法方便抽取该院2016年5月—2017年3月期间收治的92例宫内组织残留患者被随机分常规剂量组和大剂量组,每组46例,分别给予两组患者常规剂量戊酸雌二醇(2 mg/d)和大剂量戊酸雌二醇(6 mg/d)配伍地屈孕酮治疗,对比两组患者的阴道流血时间、清宫率、不良反应发生率。结果常规剂量组患者的阴道流血时间为(4.92±1.02)d,大剂量组患者的阴道流血时间为(4.01±0.98)d,两组比较,差异无统计学意义(t=2.877,P>0.05)。但常规剂量组患者的清宫率为23.91%,高于大剂量组患者的4.35%,两组比较差异有统计学意义(χ~2=4.039,P<0.05)。常规剂量组患者中,1例情绪低落,1例消化不良,总不良反应发生率为4.34%,大剂量组患者中,1例情绪低落,1例消化不良,1例乳房胀痛,不良反应发生率为6.51%,大剂量组患者的不良反应发生率略高于常规剂量组患者,但组间差异无统计学意义(χ~2=0.212,P>0.05)。结论与常规剂量戊酸雌二醇比较,大剂量戊酸雌二醇治疗宫内组织残留的疗效更好,且不良反应发生率不会明显增加。
Objective To investigate the effect of different doses of estradiol valerate in the clinical treatment of intrauterine tissue residual. Methods A total of 92 patients with intrauterine tissue admitted to our hospital from May 2016 to March 2017 were convenient selected and randomly divided into the conventional dose group and the high dose group. Each group received 46 patients, and the two groups were given conventional doses of valerate alcohol(2 mg/day) and high-dose estradiol valerate(6 mg/day) were combined with dydrogesterone. The vaginal bleeding time, clearing rate and adverse reaction rate were compared between the two groups. Results The vaginal bleeding time was(4.92±1.02) d in the routine dose group and(4.01±0.98) d in the high dose group. There was no significant difference between the two groups(t=2.877, P>0.05).However, the clearing rate was 23.91% in the conventional dose group, which was higher than 4.35% in the high-dose group. The difference between the two groups was statistically significant(χ~2=4.039, P <0.05). Among the patients in the conventional dose group, 1 patient was depressed, 1 patient had indigestion, and the total adverse reaction rate was 4.34%.Among the patients in the high-dose group, 1 patient was depressed, 1 patient had indigestion, 1 patient had breast pain,and adverse reactions occurred. The rate of adverse reactions was 6.51 significantly higher in the high-dose group than in the conventional dose group, but the difference was not statistically significant(χ~2=0.212, P>0.05). Conclusion Compared with the conventional dose of estradiol valerate, high-dose estradiol valerate is more effective in treating intrauterine tissue residues, and the incidence of adverse reactions is not significantly increased.
Objective To investigate the effect of different doses of estradiol valerate in the clinical treatment of intrauterine tissue residual. Methods A total of 92 patients with intrauterine tissue admitted to our hospital from May 2016 to March 2017 were convenient selected and randomly divided into the conventional dose group and the high dose group. Each group received 46 patients, and the two groups were given conventional doses of valerate alcohol(2 mg/day) and high-dose estradiol valerate(6 mg/day) were combined with dydrogesterone. The vaginal bleeding time, clearing rate and adverse reaction rate were compared between the two groups. Results The vaginal bleeding time was(4.92±1.02) d in the routine dose group and(4.01±0.98) d in the high dose group. There was no significant difference between the two groups(t=2.877, P>0.05).However, the clearing rate was 23.91% in the conventional dose group, which was higher than 4.35% in the high-dose group. The difference between the two groups was statistically significant(χ~2=4.039, P <0.05). Among the patients in the conventional dose group, 1 patient was depressed, 1 patient had indigestion, and the total adverse reaction rate was 4.34%.Among the patients in the high-dose group, 1 patient was depressed, 1 patient had indigestion, 1 patient had breast pain,and adverse reactions occurred. The rate of adverse reactions was 6.51 significantly higher in the high-dose group than in the conventional dose group, but the difference was not statistically significant(χ~2=0.212, P>0.05). Conclusion Compared with the conventional dose of estradiol valerate, high-dose estradiol valerate is more effective in treating intrauterine tissue residues, and the incidence of adverse reactions is not significantly increased.
引文
[1]陈运红,蒋依玲,苏莉,等.不同剂量戊酸雌二醇用于子宫纵隔切除术术后预防宫腔粘连[J].医药导报,2016,35(6):604-608.
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[9]周娟.不同剂量米非司酮配伍米索前列醇、戊酸雌二醇治疗稽留流产的疗效比较[J].现代诊断与治疗,2013,24(10):2225-2227.
[10]王竹峰.不同剂量戊酸雌二醇用于绝经后宫内节育器取出术90例[J].中国药业,2013,22(17):100-101.
[11]王明凯,王蔼明,尹善德,等.水囊联合不同剂量雌激素用于宫腔粘连辅助治疗的疗效观察[J].解放军医学院学报,2014,35(7):667-669.
[12]王显,何援利,蔡慧华,等.不同剂量戊酸雌二醇防治大鼠宫腔粘连的作用研究[J].重庆医科大学学报,2017,42(4):378-382.
[2]黄琴,吴闽君.不同剂量戊酸雌二醇用于中、重度宫腔粘连术后辅助治疗的价值评价[J].当代医学,2016,22(18):128-129.
[3]张慧莉,陈玉环,邱兰,等.不同浓度雌激素预防宫腔镜下子宫纵隔切除术后宫腔再粘连及其对妊娠结局的影响[J].医学综述,2016,22(19):3924-3926,3930.
[4]帅洁莉,张海鹰.不同剂量的戊酸雌二醇用于防治宫腔粘连分离术后再粘连的疗效研究[J].新疆医学,2016,46(9):1119-1123.
[5]王凯怡,董婕.不同剂量戊酸雌二醇用于中、重度宫腔粘连术后辅助治疗的临床疗效观察[J].生殖与避孕,2015,35(3):166-171.
[6]马晓旻,郑萍,卢丹,等.不同剂量戊酸雌二醇治疗宫腔粘连的临床效果[J].现代生物医学进展,2015,15(30):5886-5888.
[7]石岩,池余刚.不同剂量戊酸雌二醇对宫腔镜术后宫腔粘连状况的影响[J].中国妇幼保健,2015,30(30):5136-5138.
[8]王晶,陈滢,童明.不同剂量戊酸雌二醇预防宫腔粘连48例临床效果分析[J].华南国防医学杂志,2014,28(4):312-313+359.
[9]周娟.不同剂量米非司酮配伍米索前列醇、戊酸雌二醇治疗稽留流产的疗效比较[J].现代诊断与治疗,2013,24(10):2225-2227.
[10]王竹峰.不同剂量戊酸雌二醇用于绝经后宫内节育器取出术90例[J].中国药业,2013,22(17):100-101.
[11]王明凯,王蔼明,尹善德,等.水囊联合不同剂量雌激素用于宫腔粘连辅助治疗的疗效观察[J].解放军医学院学报,2014,35(7):667-669.
[12]王显,何援利,蔡慧华,等.不同剂量戊酸雌二醇防治大鼠宫腔粘连的作用研究[J].重庆医科大学学报,2017,42(4):378-382.