蛭蛇通络胶囊联合瑞舒伐他汀治疗脑梗死伴颈动脉粥样硬化斑块的临床研究
|
摘要
目的探讨蛭蛇通络胶囊联合瑞舒伐他汀治疗脑梗死伴颈动脉粥样硬化斑块的临床疗效。方法将90例该院收治的脑梗死伴颈动脉粥样硬化斑块患者分为观察组和对照组。对照组采用瑞舒伐他汀治疗。观察组在对照组基础上,采用蛭蛇通络胶囊治疗。检测二组患者的血液流变学水平。采用彩色多普勒超声检测二组患者治疗前后颈动脉斑块情况,包括IMT、斑块面积、斑块积分。结果观察组的总有效率比对照组高,差异有统计学意义(P<0.05);二组治疗后的全血黏度(WBV)、血浆黏度(PV)、血沉(ESR)、纤维蛋白原(FIB)显著降低(P<0.05);治疗后,观察组的WBV、PV、ESR、FIB比对照组低,差异有统计学意义(P<0.05);二组治疗后的IMT、斑块面积、斑块积分显著降低(P<0.05);治疗后观察组的IMT、斑块面积、斑块积分比对照组低,差异有统计学意义(P<0.05)。结论蛭蛇通络胶囊能提高脑梗死伴颈动脉粥样硬化斑块的疗效,改善血液流变学水平,降低颈动脉粥样硬化斑块。
Objective To investigate the clinical effect of Zhishetongluo capsule combined with rosuvastatin on cerebral infarction with carotid atherosclerotic plaque.Methods Ninety patients with cerebral infarction and carotid atherosclerosis plaque were divided into observation group and control group.The control group was treated with rosuvastatin.The observation group was treated with Zhishetongluo Capsule on the basis of the control group.The hemorheological levels of the two groups were measured.Carotid plaque was detected by color Doppler ultrasound before and after treatment in two groups,including IMT,plaque area and plaque score.Results The total effective rate of the observation group was higher than that of the control group(P<0.05),the blood viscosity(WBV),plasma viscosity(PV),erythrocyte sedimentation rate(ESR),fibrinogen(FIB)of the two groups were significantly lower after treatment(P<0.05);after treatment,the WBV,PV,ESR and FIB of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05);after treatment,IMT,ESR and FIB of the two groups were significantly lower than those of the control group(P<0.05).After treatment,the IMT,plaque area and plaque score of the observation group were lower than those of the control group(P<0.05).Conclusion Zhishetongluo Capsule can improve the curative effect of cerebral infarction with carotid atherosclerotic plaque,improve the level of hemorheology,reduce carotid atherosclerotic plaque.
Objective To investigate the clinical effect of Zhishetongluo capsule combined with rosuvastatin on cerebral infarction with carotid atherosclerotic plaque.Methods Ninety patients with cerebral infarction and carotid atherosclerosis plaque were divided into observation group and control group.The control group was treated with rosuvastatin.The observation group was treated with Zhishetongluo Capsule on the basis of the control group.The hemorheological levels of the two groups were measured.Carotid plaque was detected by color Doppler ultrasound before and after treatment in two groups,including IMT,plaque area and plaque score.Results The total effective rate of the observation group was higher than that of the control group(P<0.05),the blood viscosity(WBV),plasma viscosity(PV),erythrocyte sedimentation rate(ESR),fibrinogen(FIB)of the two groups were significantly lower after treatment(P<0.05);after treatment,the WBV,PV,ESR and FIB of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05);after treatment,IMT,ESR and FIB of the two groups were significantly lower than those of the control group(P<0.05).After treatment,the IMT,plaque area and plaque score of the observation group were lower than those of the control group(P<0.05).Conclusion Zhishetongluo Capsule can improve the curative effect of cerebral infarction with carotid atherosclerotic plaque,improve the level of hemorheology,reduce carotid atherosclerotic plaque.
引文
[1]黄金华,陈伟,辛家厚,等.国内进展性脑梗死危险因素的系统评价[J].中西医结合心脑血管病杂志,2016,14(14):1575-1579
[2]张亚楠,邢瑜,李辉,等.颈动脉粥样硬化斑块与脑梗死的临床相关分析[J].脑与神经疾病杂志,2016,12(2):108-112
[3]贺曦,张敏,杨柳,等.瑞舒伐他汀钙对脑梗死患者动脉粥样硬化及脑血流动力学的改善作用研究[J].检验医学与临床,2016,13(16):2276-2277
[4]王永刚,于远望,钟伟,等.蛭蛇通络胶囊对脑梗死恢复期患者血脂、血液流变学的影响[J].中华中医药学刊,2017,9(10):2492-2494
[5]中医学会神经病学分会脑血管病学组急性缺血脑卒中诊治指南撰学组.中国急性缺血性脑卒中诊治指南2010[J].中国全科医学,2011,35(2):16-19
[6]Dunning K.National Institutes of Health Stroke Scale[J].Encyclopedia of Clinical Neuropsychology,2011,9(1):1714-1715
[7]国家中医药管理局脑病急症协作组.中风病诊断、疗效评定标准[J].北京中医药大学学报,1996,19(1):55-57
[8]段春苗,石富铭.颈动脉斑块分布、性质及狭窄程度与脑梗死的相关性分析[J].中国煤炭工业医学杂志,2017,20(4):440-443
[9]陈斌.瑞舒伐他汀对脑梗死合并颈动脉粥样硬化斑块患者的疗效观察[J].中国医药导报,2011,08(29):61-62
[10]冯志强,陆云南,许红,等.瑞舒伐他汀治疗急性脑梗死合并颈动脉粥样硬化斑块患者的疗效观察及对内皮功能的影响[J].贵州医药,2017,20(12):1289-1291
[11]甘佳乐,徐武清,刘敬霞,等.中医药治疗脑梗死研究进展[J].吉林中医药,2016,12(2):214-216
[12]么红英,王照平,李伟,等.蛭蛇通络胶囊联合阿司匹林对脑梗死患者凝血功能影响的研究[J].医学临床研究,2016,33(5):1020-1022
[13]王永刚,李彩红,于远望,等.蛭蛇通络胶囊联合西药治疗缺血性脑卒中恢复期78例临床观察[J].中医杂志,2015,56(19):1659-1662
[14]饶才辉,妥佳,张玉珍,等.急性脑梗死血液流变学指标临床观察[J].人民军医,2000,8(9):528-528
[15]杨耀国,陈忠,唐小斌,等.颈动脉狭窄稳定斑块与易损斑块患者的临床特征分析[J].中国医药,2018,13(7):1021-1024
[2]张亚楠,邢瑜,李辉,等.颈动脉粥样硬化斑块与脑梗死的临床相关分析[J].脑与神经疾病杂志,2016,12(2):108-112
[3]贺曦,张敏,杨柳,等.瑞舒伐他汀钙对脑梗死患者动脉粥样硬化及脑血流动力学的改善作用研究[J].检验医学与临床,2016,13(16):2276-2277
[4]王永刚,于远望,钟伟,等.蛭蛇通络胶囊对脑梗死恢复期患者血脂、血液流变学的影响[J].中华中医药学刊,2017,9(10):2492-2494
[5]中医学会神经病学分会脑血管病学组急性缺血脑卒中诊治指南撰学组.中国急性缺血性脑卒中诊治指南2010[J].中国全科医学,2011,35(2):16-19
[6]Dunning K.National Institutes of Health Stroke Scale[J].Encyclopedia of Clinical Neuropsychology,2011,9(1):1714-1715
[7]国家中医药管理局脑病急症协作组.中风病诊断、疗效评定标准[J].北京中医药大学学报,1996,19(1):55-57
[8]段春苗,石富铭.颈动脉斑块分布、性质及狭窄程度与脑梗死的相关性分析[J].中国煤炭工业医学杂志,2017,20(4):440-443
[9]陈斌.瑞舒伐他汀对脑梗死合并颈动脉粥样硬化斑块患者的疗效观察[J].中国医药导报,2011,08(29):61-62
[10]冯志强,陆云南,许红,等.瑞舒伐他汀治疗急性脑梗死合并颈动脉粥样硬化斑块患者的疗效观察及对内皮功能的影响[J].贵州医药,2017,20(12):1289-1291
[11]甘佳乐,徐武清,刘敬霞,等.中医药治疗脑梗死研究进展[J].吉林中医药,2016,12(2):214-216
[12]么红英,王照平,李伟,等.蛭蛇通络胶囊联合阿司匹林对脑梗死患者凝血功能影响的研究[J].医学临床研究,2016,33(5):1020-1022
[13]王永刚,李彩红,于远望,等.蛭蛇通络胶囊联合西药治疗缺血性脑卒中恢复期78例临床观察[J].中医杂志,2015,56(19):1659-1662
[14]饶才辉,妥佳,张玉珍,等.急性脑梗死血液流变学指标临床观察[J].人民军医,2000,8(9):528-528
[15]杨耀国,陈忠,唐小斌,等.颈动脉狭窄稳定斑块与易损斑块患者的临床特征分析[J].中国医药,2018,13(7):1021-1024