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Objective: To investigate the correlation between warfarin plasma concentration and international normalized ratio (INR) in patients with heart valve replacement in the northeast of Sichuan to provide reference for clinical rational drug use. Methods: Totally 67 patients with heart valve replacement treated with warfarin were chosen for the study from 2015 to 2017 in the northeast of Sichuan. HPLC was employed to measure the plasma concentration of warfarin,and an ACL200 automated coagulometer was used to monitor INR. Results: The results showed that the mean plasma concentration was (613. 7 ± 149. 6) ng·ml~(-1) in the 67 patients.Meanwhile,the coefficient was 0. 24 (0. 1 < P < 0. 2) for warfarin dosage with INR; the coefficient was 0. 23 (0. 3 < P < 0. 5) for warfarin plasma concentration with INR. Conclusion: The correlation is poor between warfarin plasma concentration and INR in the northeast of Sichuan. Meanwhile,in order to adjust the dosage more objectively and accurately,warfarin plasma concentration monitoring is necessary and helpful for clinical rational drug use.
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