红细胞分布宽度及超敏C反应蛋白水平变化与急性脑梗死的关系
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摘要
目的探讨红细胞分布宽度(RDW)及超敏C反应蛋白(hs-CRP)水平变化与急性脑梗死的关系。方法选取2016年2月～2017年3月我院内科收治的70例脑梗死患者作为观察组,另选取同期我院门诊接收的66例健康体检者作为对照组,采用免疫增强比浊法和血液分析仪测量法,分别检测两组的hs-CRP水平和RDW,分析RDW及hs-CRP水平变化对急性脑梗死的影响。结果观察组的血清hs-CRP水平为(14.30±0.51)mg/L,RDW为(23.06±4.61)%,均高于对照组的(7.28±0.49)mg/L、(12.48±3.81)%,差异有统计学意义(P<0.05)。观察组的病变部位血管腔面积为(7.62±2.21)mm2,大于对照组的(6.51±1.91)mm2,差异有统计学意义(P<0.05)。hs-CRP水平与病变部位血管腔面积成正相关(r=0.326,P=0.001),RDW与病变部位血管腔面积成正相关(r=0.321,P=0.002)。结论检测急性脑梗死患者血清hs-CRP水平及RDW对患者疾病预测及治疗具有重要的临床意义。
Objective To investigate the relationship between red blood cell distribution width(RDW) and high sensitivity C reactive protein(hs-CRP) level and acute cerebral infarction. Methods Seventy patients with cerebral infarction admitted to our hospital from February 2016 to March 2017 were selected as the observation group, and 66 healthy subjects who received medical examination from the outpatient of our hospital were selected as the control group. Immunoenhanced turbidimetry and blood analysis instrumental measurement method were used to detect hs-CRP levels and RDW in the two groups, and to analyze the effect of RDW and hs-CRP levels on acute cerebral infarction. Results The serum hs-CRP level of the observation group was(14.30±0.51) mg/L, the RDW was(23.06±4.61) %, which was higher than that of the control group for(7.28±0.49) mg/L,(12.48±3.81) %, and the differences were statistically significant(P<0.05). The vascular lumen area of the lesion in the observation group was(7.62±2.21) mm2, which was larger than that in the control group of(6.51±1.91) mm2, and the difference was statistically significant(P<0.05). The level of hs-CRP was positively correlated with the vascular lumen area of the lesion(r=0.326, P=0.001), and RDW was positively correlated with the vascular lumen area of the lesion(r=0.321, P=0.002). Conclusion Detection of serum level of hs-CRP and RDW in patients with acute cerebral infarction has important clinical significance for disease prediction and treatment.
Objective To investigate the relationship between red blood cell distribution width(RDW) and high sensitivity C reactive protein(hs-CRP) level and acute cerebral infarction. Methods Seventy patients with cerebral infarction admitted to our hospital from February 2016 to March 2017 were selected as the observation group, and 66 healthy subjects who received medical examination from the outpatient of our hospital were selected as the control group. Immunoenhanced turbidimetry and blood analysis instrumental measurement method were used to detect hs-CRP levels and RDW in the two groups, and to analyze the effect of RDW and hs-CRP levels on acute cerebral infarction. Results The serum hs-CRP level of the observation group was(14.30±0.51) mg/L, the RDW was(23.06±4.61) %, which was higher than that of the control group for(7.28±0.49) mg/L,(12.48±3.81) %, and the differences were statistically significant(P<0.05). The vascular lumen area of the lesion in the observation group was(7.62±2.21) mm2, which was larger than that in the control group of(6.51±1.91) mm2, and the difference was statistically significant(P<0.05). The level of hs-CRP was positively correlated with the vascular lumen area of the lesion(r=0.326, P=0.001), and RDW was positively correlated with the vascular lumen area of the lesion(r=0.321, P=0.002). Conclusion Detection of serum level of hs-CRP and RDW in patients with acute cerebral infarction has important clinical significance for disease prediction and treatment.
引文
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[2]赵亚飞,杜雪平,董建琴.脑卒中社区防治的现状及存在的问题[J].中国全科医学,2010,13(14):1493-1495.
[3]解冰川,李艳敏,王彦永,等.MMP-9及hs-CRP与动脉粥样硬化、脑卒中关系的研究进展[J].临床误诊误治,2013,26(5):97-100.
[4]卜聪亚,周玉杰,赵迎新,等.高龄冠心病伴房颤患者hsCRP、和颈动脉粥样硬化的检测及意义[J].临床心血管病杂志,2014,16(1):59-61.
[5]胡波,万顺.血清超敏C-反应蛋白的表达与急性脑梗死的相关性分析[J].吉林医学,2013,34(5):825-826.
[6]陈伟伟,高润霖,刘力生,等.中国心血管病报告2013概要[J].中国循环杂志,2014,29(7):487-491.
[7]何晓全,刘梅林.中国冠心病防治策略[J].中国全科医学,2015,18(2):239-240.
[8]王波,王临池,赵翼洪,等.2009-2013年苏州20岁及以上居民冠心病发病率变化趋势及类型分析[J].中国全科医学,2015,18(24):2952-2956.
[9]杨曙光,汤学超.血清胱抑素C水平与冠心病严重程度的关系[J].中国动脉硬化杂志,2014,22(12):1247-1250.
[10]何姗姗,王晓燕,赵英帅,等.冠心病患者冠状动脉病变程度与血清胱抑素C及内皮功能相关性分析[J].重庆医学,2017,46(1):64-71.
[11]刘春晓,谭鹤长,宋雪霞,等.Cys-C在急性有机磷农药中毒急性肾损伤诊断中的应用[J].广西医科大学学报,2013,30(6):931-933.
[12].张宜春,徐岩.ACS患者红细胞分布宽度与GRACE评分及心功能的关联性分析[J].华中科技大学学报(医学版),2016,45(2):160-163.
[13]Senol K,Gündogdu SB,Ozkan B,et al.External validation of the new Japanese severity score in Turkish patients with acute pancreatitis[J].Pancreas,2014,43(3):487-488.
[14]Sadaka F,O′Brien J,Prakash S.Red cell distribution width and outcome in patients with septic shock[J].J Intensive Care Med,2013,28(5):307-313.
[15]吴丽娟.同型半胱氨酸、超敏C反应蛋白、胱抑素C和纤维蛋白原与急性脑梗死患者关系的研究[J].当代医学,2017,23(32):54-56.
[16]Vaya A,Hernández JL,Zorio E,et al.Association between red blood cell distribution width and the risk of future cardiovascular events[J].Clin Hemorheol Microcirc,2012,50(3):221-225.
[17]陈孝强,杨汉东,陈俊.血清C1q、超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性研究[J].中国医药导报,2017,14(35):41-44.