从褪黑素角度浅谈中医整体观在女性生殖节律中的体现
摘要
生物节律广泛存在于自然界,是大多数生物的基本特征。生物节律是机体逐步进化的结果,在适应环境变化、维持内环境稳定等方面起着重要的作用。褪黑素受到光信号-视网膜-下丘脑视交叉上核(SCN)通路调节,随着光暗循环的变化,呈现昼低夜高的近日节律,向人体各个系统发送"时间信号",是重要的授时因子,在生物节律的调节中具有重要的作用。很多研究发现,褪黑素通过影响生物节律,对女性生殖系统具有重要的调节作用,包括月经周期、受孕、分娩等。中医自古就认识到人与自然是一个整体,天人相应是中医整体观的体现,认为外界环境变化可以影响人体的生理,文章拟从中西医结合探讨褪黑素对女性生殖节律的影响。
引文
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[2]Malpaux B,Migaud M,Tricoire H,et al.Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin[J].J Biol Rhythms,2001,16(4):336.
[3]Rojansky N,Benshushan A,Meirsdorf S,et al.Seasonal variability in fertilization and embryo quality rates in women undergoing IVF[J].Fertil Steril,2000,74(3):476.
[4]Braga DP,Setti A,Figueira Rde C,et al.Seasonal variability in the fertilization rate of women undergoing assisted reproduction treatments[J].Gynecol Endocrinol,2012,28(7):549.
[5]Wood S,Quinn A,Troupe S,et al.Seasonal variation in assisted conception cycles and the influence of photoperiodism on outcome in in vitro fertilization cycles[J].Hum Fertil(Camb),2006,9(4):223.
[6]Labyak S,Lava S,Turek F,et al.Effects of shiftwork on sleep and menstrual function in nurses[J].Health Care Women Int,2002,23(6-7):703.
[7]Preston FS,Bateman SC,Short RV,et al.Effects of flying and of time changes on menstrual cycle length and on performance in airline stewardesses[J].Aerosp Med,1973,44(4):438.
[8]Hall JE,Sullivan JP,Richardson GS.Brief wake episodes modulate sleep-inhibited luteinizing hormone secretion in the early follicular phase[J].J Clin Endocrinol Metab,2005,90(4):2050.
[9]Axelsson G,Rylander R,Molin I.Outcome of pregnancy in relation to irregular and inconvenient work schedules[J].Br J Ind Med,1989,46(6):393.
[10]Cagnacci A.Melatonin in relation to physiology in adult humans[J].J Pineal Res,1996,21(4):200.
[11]Rex M,Kripke D F,Cole R J,et al.Nocturnal light effects on menstrual cycle length[J].J Altern Complement Med,1997,3(4):387.
[12]Berga S L,Mortola,J.F.et al.Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea[J].J Clin Endocrinol Meta,1988,66(1):242.
[13]Kostoglou-Athanassiou I,Athanassiou P,Treacher DF,et al.Neurohypophysial hormone and melatonin secretion over the natural and suppressed menstrual cycle in premenopausal women[J].Clin Endocrinol,1998,49(2):209.
[14]Shechter A,Lespeerance P.Ng Ying Kin NM,et al.Pilot investigation of the circadian plasma melatonin rhythm across the menstrual cycle in a small group of women with premenstrual dysphoric disorder[J].Plo S One,2012,7(12):51929.
[15]Baker FC,Dniver HS.et al.Circadian rhythms,sleep,and the menstrual cycle[J].Sleep Med,2007,8(6):613.
[16]Rojansky N,Benshushan A,Meirsdorf S,et al.Seasonal variability in fertilization and embryo quality rates in women undergoing IVF[J].Fertil Steril,2000,74(3):476.
[17]Braga DP,Setti A,Figueira Rde C,et al.Seasonal variability in the fertilization rate of women undergoing assisted reproduction treatments[J].Gynecol Endocrinol,2012,28(7):549.
[18]Glattre E,Bjerkedal T.The 24-hour rhythmicity of birth:a population study[J].Acta Obstet Gynecol Scand 1983,62(1):31.
[19]Cagnacci A,SoldaniR,Melis GB,et al.Diurnal rhythms of labor and delivery in women:modulation by parity and reasons[J].Am J Obst Gynecol,1998,178(1):140.
[20]Lindow SW,Jha RR,Thompson JW.24-hour rhythm to the onset of preterm labor[J].Br J Obstet Gynecol,2000,107(9):1145.
[21]Schlabritz-Loutsevitch N,Hellner N,Middendorf R,et al.The human myometrium as a target for melatonin[J].J Clin Endocrinol Metab[J]2003,88(2):908.
[22]Sharkey JT,Cable C,Olcese J.Melatonin sensitizes human myometrial cells to oxytocin in a PKCa/ERK-dependent manner[J].J Clin Endocrinol Metab,2010,95(6):2902.
[23]Olcese J,Lazier S,Paradise C.Melatonin and the circadian timing of human parturition[J].Reprod Sci,2013,20(2):168.
[24]夏桂成.试探月经周期中圆运动生物钟规律[J].南京中医药大学学报,1997,13(5):262.