Ghrelin在应激状态下对机体保护作用的研究进展
|
摘要
Ghrelin是一种胃分泌素,具有多种生物学作用,对机体的功能发挥广泛的影响。近几年的研究发现,在病理状态下,Ghrelin对机体多个器官系统可发挥保护作用。本文从应激的这一角度出发,对10年来Ghrelin在应激状态下对机体各个器官系统的保护作用做一综述。
引文
1 Absi M. Stress and addiction:when a robust stress response indicates resiliency. Psychosom Med,2018,80:2~16.
2 Kemp BA,Howell NL,Gildea JJ,et al. Intrarenal ghrelin receptor antagonism prevents high-fat diet-induced hypertension in male rats. Endocrinology,2014,155:2658~2666.
3 Nojiri T,Hosoda H,Kimura T,et al. Protective effects of ghrelin on cisplatin-induced nephrotoxicity in mice. Peptides,2016,82:85~91.
4 Sun GX,Ding R,Li M,et al. Ghrelin attenuates renal fibrosis and inflammation of obstructive nephropathy. J Urol,2015,193:2107~2115.
5 Mao Y,Zhang S,Yu F,et al. Ghrelin attenuates liver fibrosis through regulation of TGF-beta1 expression and autophagy. Int J Mol Sci,2015,16:21911~21930.
6 Qin Y,Li Z,Wang Z,et al. Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion. Liver Int,2014,34:567~575.
7 Kamiide Y,Inomata N,Furuya M,et al. Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats. Eur J Pharmacol,2015,755:88~94.
8 Huang HJ,Zhu XC,Han QQ,et al. Ghrelin alleviates anxiety-and depression-like behaviors induced by chronic unpredictable mild stress in rodents. Behav Brain Res,2017,326:33~43.
9 Gorbunov NV,Kiang JG. Ghrelin therapy decreases incidents of intracranial hemorrhage in mice after whole-body ionizing irradiation combined with burn trauma. Int J Mol Sci,2017,18:1693.
10 陈丹,李士通.糖皮质激素性肌病研究进展.上海医学,2013,36:905~909.
11 Chen JA,Splenser A,Guillory B,et al. Ghrelin prevents tumour-and cisplatin-induced muscle wasting:characterization of multiple mechanisms involved. J Cachexia Sarcopenia Muscle,2015,6:132~143.
12 Mao Y,Li Z,Chen K,et al. Antinociceptive effect of ghrelin in a rat model of irritable bowel syndrome involves TRPV1/opioid systems. Cell. Physiol. Biochem,2017,43:518~530.
13 Zou YC,Chen LH,Ye YL,et al. Attenuated synovial fluid ghrelin levels are linked with cartilage damage,meniscus injury,and clinical symptoms in patients with knee anterior cruciate ligament deficiency. Discov Med,2016,22:325~335.
14 Mirzaie BF,Mohaddes G,Ebrahimi H,et al. Ghrelin increases lymphocytes in chronic normobaric hypoxia. Adv Pharm Bull,2014,4:339~343.
2 Kemp BA,Howell NL,Gildea JJ,et al. Intrarenal ghrelin receptor antagonism prevents high-fat diet-induced hypertension in male rats. Endocrinology,2014,155:2658~2666.
3 Nojiri T,Hosoda H,Kimura T,et al. Protective effects of ghrelin on cisplatin-induced nephrotoxicity in mice. Peptides,2016,82:85~91.
4 Sun GX,Ding R,Li M,et al. Ghrelin attenuates renal fibrosis and inflammation of obstructive nephropathy. J Urol,2015,193:2107~2115.
5 Mao Y,Zhang S,Yu F,et al. Ghrelin attenuates liver fibrosis through regulation of TGF-beta1 expression and autophagy. Int J Mol Sci,2015,16:21911~21930.
6 Qin Y,Li Z,Wang Z,et al. Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion. Liver Int,2014,34:567~575.
7 Kamiide Y,Inomata N,Furuya M,et al. Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats. Eur J Pharmacol,2015,755:88~94.
8 Huang HJ,Zhu XC,Han QQ,et al. Ghrelin alleviates anxiety-and depression-like behaviors induced by chronic unpredictable mild stress in rodents. Behav Brain Res,2017,326:33~43.
9 Gorbunov NV,Kiang JG. Ghrelin therapy decreases incidents of intracranial hemorrhage in mice after whole-body ionizing irradiation combined with burn trauma. Int J Mol Sci,2017,18:1693.
10 陈丹,李士通.糖皮质激素性肌病研究进展.上海医学,2013,36:905~909.
11 Chen JA,Splenser A,Guillory B,et al. Ghrelin prevents tumour-and cisplatin-induced muscle wasting:characterization of multiple mechanisms involved. J Cachexia Sarcopenia Muscle,2015,6:132~143.
12 Mao Y,Li Z,Chen K,et al. Antinociceptive effect of ghrelin in a rat model of irritable bowel syndrome involves TRPV1/opioid systems. Cell. Physiol. Biochem,2017,43:518~530.
13 Zou YC,Chen LH,Ye YL,et al. Attenuated synovial fluid ghrelin levels are linked with cartilage damage,meniscus injury,and clinical symptoms in patients with knee anterior cruciate ligament deficiency. Discov Med,2016,22:325~335.
14 Mirzaie BF,Mohaddes G,Ebrahimi H,et al. Ghrelin increases lymphocytes in chronic normobaric hypoxia. Adv Pharm Bull,2014,4:339~343.