紫锥菊的免疫调节作用及其在水产养殖中的应用进展
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摘要
紫锥菊Echinacea purpora是一种富含咖啡酸衍生物、烷基酰胺类物质及多糖和糖蛋白等多种活性物质的多年生菊科植物,紫锥菊及其提取物具有显著的免疫调节和促生长作用,在人类医学中应用广泛,在畜牧业和水产养殖中的应用也日益增多。本研究中对紫锥菊的主要活性成分、免疫调节作用与机制,以及紫锥菊在水产养殖业中的应用现状进行了系统的综述,针对紫锥菊在水产养殖应用中存在的问题,提出今后应在紫锥菊所作用的水产动物的多样性、促进生长及调节免疫的具体作用机制,以及使用策略、复合效果、提取工艺等方面加强研究,本研究结果可为紫锥菊在水产养殖上的推广应用提供参考。
Echinacea purpurea as a perennial plant contains abundant bioactive substances including caffeic acid derivatives, alkamides, polysaccharides and glycoproteins, together with its extracts, has been widely used in human medicine, as well as increasingly in animal husbandry and aquaculture for remarkable role of immune regulation and growth promotion. The main active ingredient, mechanism of immunoregulation and the application actuality of E.purpurea in aquaculture were systematically reviewed in present paper. In view of the problems existing in the application of E.purpurea in aquaculture, it was proposed that further research should be carried out on the diversity of aquatic animals affected by E.purpurea, the specific mechanism of promoting growth and regulating immunity, the use strategies, compound effects and extraction technology on the active ingredients of E.purpurea.
Echinacea purpurea as a perennial plant contains abundant bioactive substances including caffeic acid derivatives, alkamides, polysaccharides and glycoproteins, together with its extracts, has been widely used in human medicine, as well as increasingly in animal husbandry and aquaculture for remarkable role of immune regulation and growth promotion. The main active ingredient, mechanism of immunoregulation and the application actuality of E.purpurea in aquaculture were systematically reviewed in present paper. In view of the problems existing in the application of E.purpurea in aquaculture, it was proposed that further research should be carried out on the diversity of aquatic animals affected by E.purpurea, the specific mechanism of promoting growth and regulating immunity, the use strategies, compound effects and extraction technology on the active ingredients of E.purpurea.
引文
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[2]Capek P,utovskáM,KocmálováM,et al.Chemical and pharmacological profiles of Echinacea complex[J].International Journal of Biological Macromolecules,2015,79:388-391.
[3]Tiralongo E,Wee S S,Lea R A.Elderberry supplementation reduces cold duration and symptoms in air-travellers:arandomized,double-blind placebo-controlled clinical trial[J].Nutrients,2016,8(4):182.
[4]Schapowal A,Klein P,Johnston S L.Echinacea reduces the risk of recurrent respiratory tract infections and complications:a meta-analysis of randomized controlled trials[J].Advances in Therapy,2015,32(3):187-200.
[5]Dogan Z,Ergul B,Sarikaya M,et al.The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid[J].Bratislavske Lekarske Listy,2014,115(7):411-415.
[6]Fonseca F N,Papanicolaou G,Lin H,et al.Echinacea purpurea(L.)moench modulates human T-cell cytokine response[J].International Immunopharmacology,2014,19(1):94-102.
[7]Oláh A,Szabó-Papp J,Soeberdt M,et al.Echinacea purpurea-derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema[J].Journal of Dermatological Science,2017,88(1):67-77.
[8]Bruni R,Brighenti V,Caesar L K,et al.Analytical methods for the study of bioactive compounds from medicinally used Echinacea species[J].Journal of Pharmaceutical and Biomedical Analysis,2018,160:443-477.
[9]Gertsch J,Schoop R,Kuenzle U,et al.Echinacea alkylamides modulate TNF-αgene expression via cannabinoid receptor CB2 and multiple signal transduction pathways[J].FEBS Letters,2004,577(3):563-569.
[10]Manayi A,Vazirian M,Saeidnia S.Echinacea purpurea:pharmacology,phytochemistry and analysis methods[J].Pharmacognosy Reviews,2015,9(17):63-72.
[11]Jiang R W,Lau K M,Hon P M,et al.Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza[J].Current Medicinal Chemistry,2005,12(2):237-246.
[12]Ferlemi A V,Katsikoudi A,Kontogianni V G,et al.Rosemary tea consumption results to anxiolytic-and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity;phytochemical investigation and in silico studies[J].Chemico-Biological Interactions,2015,237:47-57.
[13]Cilliers J J L,Singleton V L,Lamuela-Raventos R M.Total polyphenols in apples and ciders;correlation with chlorogenicacid[J].Journal of Food Science,1990,55(5):1458-1459.
[14]李治颖,张晶,程飞,等.紫锥菊抗氧化作用及机理研究进展[J].中兽医医药杂志,2016(4):72-74.
[15]Liu J J,Yang L L,Dong Y H,et al.Echinacoside,an inestimable natural product in treatment of neurological and other disorders[J].Molecules,2018,23(5):1213-1236.
[16]李圣军.相转移萃取法高效分离紫锥菊中菊苣酸的方法研究[D].长沙:湖南师范大学,2012.
[17]Gulledge T V,Collette N M,Mackey E,et al.Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide[J].Journal of Ethnopharmacology,2018,212:166-174.
[18]Brush J,Mendenhall E,Guggenheim A,et al.The effect of Echinacea purpurea,Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans[J].Phytotherapy Research,2006,20(8):687-695.
[19]Boonen J,Bronselaer A,Nielandt J,et al.Alkamiddatabase:chemistry,occurrence and functionality of plant N-alkylamides[J].Journal of Ethnopharmacology,2012,142(3):563-590.
[20]Todd D A,Gulledge T V,Britton E R,et al.Ethanolic Echinacea purpurea extracts contain a mixture of cytokine-suppressive and cytokine-inducing compounds,including some that originate from endophytic bacteria[J].PLoS One,2015,10(5):e0124276.https://doi.org/10.1371/journal.pone.0124276.
[21]Mudge E,Lopes-Lutz D,Brown P,et al.Analysis of alkylamides in Echinacea plant materials and dietary supplements by ultrafast liquid chromatography with diode array and mass spectrometric detection[J].Journal of Agricultural and Food Chemistry,2011,59(15):8086-8094.
[22]陆英,李佳银,李觅路,等.高速逆流色谱法结合高效液相色谱法制备紫锥菊根中烷基酰胺类化合物[J].中国生化药物杂志,2012,33(4):333-336,341.
[23]Dalby-Brown L,Barsett H,Landbo A K R,et al.Synergistic antioxidative effects of alkamides,caffeic acid derivatives,and polysaccharide fractions from Echinacea purpureaon in vitro oxidation of human low-density lipoproteins[J].Journal of Agricultural and Food Chemistry,2005,53(24):9413-9423.
[24]Proksch A,Wagner H.Structural analysis of a 4-O-methyl-glucuronoarabinoxylan with immuno-stimulating activity from Echinacea purpurea[J].Phytochemistry,1987,26(7):1989-1993.
[25]付石军,郭时金,张志美,等.紫锥菊的药理作用及其在动物生产中的应用[J].中国饲料,2013(7):28-31.
[26]Yang G,Li K K,Liu C,et al.A comparison of the immunostimulatory effects of polysaccharides from tetraploid and diploid Echinacea purpurea[J].Biomed Research International,2018.https://doi.org/10.1155/2018/8628531.
[27]Oniszczuk T,Oniszczuk A,Gondek E,et al.Active polyphenoliccompounds,nutrient contents and antioxidant capacity of extruded fish feed containing purple coneflower(Echinacea purpurea(L.)Moench.)[J].Saudi Journal of Biological Sciences,2019,26(1):24-30.
[28]张晶,李治颖,程飞,等.紫锥菊抗氧化作用分子机理研究进展[J].当代畜牧,2016(36):44-46.
[29]Glavac N K,Koir I J,Rode J,et al.Optimization and use of a spectrophotometric method for determining polysaccharides in Echinacea purpurea[J].Central European Journal of Biology,2012,7(1):126-131.
[30]Oskoii S B,Kohyani A T,Parseh A,et al.Effects of dietary administration of Echinacea purpurea on growth indices and biochemical and hematological indices in rainbow trout(Oncorhynchus mykiss)fingerlings[J].Fish Physiology and Biochemistry,2012,38(4):1029-1034.
[31]Raduner S,Majewska A,Chen J Z,et al.Alkylamides from Echinacea are a new class of cannabinomimetics.Cannabinoid type 2receptor-dependent and-independent immunomodulatory effects[J].Journal of Biological Chemistry,2006,281(20):14192-14206.
[32]Müller-Jakic B,Breu W,Pr9bstle A,et al.In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species[J].Planta Medica,1994,60(1):37-40.
[33]Gupta M,Sharma D,Sharma A,et al.A review on purple cone flower(Echinacea purpurea L.Moench)[J].Journal of Pharmacy Research,2012,5(8):4076-4081.
[34]Zhai Z L,Solco A,Wu L K,et al.Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells,indicative of alternative macrophage activation[J].Journal of Ethnopharmacology,2009,122(1):76-85.
[35]Fast D J,Balles J A,Scholten J D,et al.Echinacea purpurea root extract inhibits TNF release in response to Pam3Csk4in a phosphatidylinositol-3-kinase dependent manner[J].Cellular Immunology,2015,297(2):94-99.
[36]徐歆.紫锥菊提取物对小鼠免疫和抗沙门氏菌感染能力的影响及其机理研究[D].杭州:浙江大学,2014.
[37]牛小飞,王宏艳,张晶晶.紫锥菊对免疫抑制小鼠免疫功能的调节作用[J].中国兽医杂志,2015,51(2):50-52.
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