摘要
目的:探究地黄饮子联合耳针对肾虚髓减型内分泌治疗期绝经后乳腺癌患者认知水平、临床症状及生化指标的影响。方法:100例接受内分泌治疗的绝经后乳腺癌患者,根据入院先后使用数字表法随机分为实验组和对照组,实验组患者50例,对照组患者50例。对照组患者接受常规乳腺癌内分泌、补钙治疗加耳针治疗,治疗组患者在对照组基础上服用地黄饮子煎剂,两组患者均连续治疗2个月后进行MMSE、MoCA、FSS量表评估,检测患者生化指标:游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、雌二醇(E2)、促黄体生成素(LH)、促卵泡生成素(FSH)、胆固醇(TC)、甘油三酯(TG)、维生素D3(1,25-(OH)2-VitD3)。结果:治疗组总有效率高于对照组;治疗后两组认知评分均较治疗前有所提高(P<0.05),而治疗后治疗组认知评分高于对照组(P<0.05);治疗后两组疲劳评分均较治疗前有所降低(P<0.05),而治疗后治疗组认知评分低于对照组(P<0.05);治疗后两组FT3、FT4、TSH、E2、LH、1,25-(OH)2-VitD3水平均较治疗前提高(P<0.05),而治疗后治疗组上述指标高于对照组(P<0.05);治疗后两组TC、TG、LH、FSH均较治疗前有所降低(P<0.05),而治疗后治疗组上述指标低于对照组(P<0.05)。结论:地黄饮子联合耳针可以有效地改善肾虚髓减型内分泌治疗期绝经后乳腺癌患者认知水平,其作用可能与相关激素水平、血脂及血清D3含量改变有关,且安全可靠,值得研究。
Objective: To investigate the effect of Rehmanniae Decoction combined with auricular acupuncture in improving the cognitive level, alleviating symptoms, influencing index of patients with postmenopausal breast cancer who received endocrine therapy and differentiated as kidney deficiency and marrow injury. Method: A total of 100 postmenopausal breast cancer patients were selected. According to different methods of treatment, the patients were divided into experimental group(n=50) and control group(n=50). Patients in the control group received auricular acupuncture,endocrine therapy and calcium supplementation, while those in the experimental group took Rehmannia Decoction on the basis of the control group. Mini-mental State Examination(MMSE),Montreal Congnitive Assessment(MoCA) and FSS were assessed and some indexes such as FT3,FT4,TSH,E2,LH,FSH,TC,TG and 1,25-(OH)2-VitD3 were tested before and after 2 months treatment. Results: The experimental group's total effective rate was higher than that of the control group. The MMSE score and MoCA score of patients in each group increased after treatment while the socres in experimental group were higher than those in the control group(P<0.05). The FSS score of patients in each group decreased after treatment while the socres in experimental group were lower than those in the control group(P<0.05). The levels of indexes(FT3,FT4,TSH,E2,LH,1,25-(OH)2-VitD3) of patients in each group wereincreased after treatment, while the levels in experimental group were higher than those in the control group(P<0.05). The levels of indexes(TC,TG,LH,FSH) of patients in each group were lower after treatment, while the levels in experimental group were lower than those in the control group(P<0.05). Conclusion: Rehmanniae Decoction combined with auricular acupuncture can effectively improve the cognitive level. Its effect may be associated with changes of hormone level, blood lipid and vitamin D content. It is safe and worthy of studying.
引文
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