地龙低温超微粉碎特性考察
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摘要
目的:考察地龙低温超微粉碎的工艺参数及粉体学性质。方法:采用高速中药粉碎机将地龙粉碎至均匀粒度,利用振动式低温超微粉碎机对地龙粉末进行再次粉碎,每3 min取样,直至25 min全部取出,检测样品粒径、比表面积及孔隙率。结果:随粉碎时间的增加,粒径先逐渐减小,而后粒子开始团聚使粒径增加;比表面积及孔隙率随粉碎时间先增加后减小。吸附-脱附曲线显示发生凝聚和蒸发时相对压力集中分布于0.8~1.0;粉碎9 min样品中N2吸附量最大,且与其余样品存在明显差异。结论:振动式超微粉碎可将地龙粉碎至微米级,低温粉碎可保证地龙有效成分不发生变化,且达适宜粉碎粒径后不容易聚集,符合小金丸粒子设计对地龙的要求。
Objective: To investigate process parameters and powder characteristics of Pheretima after low temperature pulverization. Method: Pheretima was crushed again by vibration type low temperature ultrafine pulverizer after it was crushed to uniform particle size with high speed grinderof Chinese medicine,sampling every 3 min until all samples out of machine by 25 min,then particle size,specific surface area and porosity of samples were tested. Result: With increasing of grinding time,particle size decreased gradually,then particle size increased after agglomeration of particles; specific surface area and porosity increased firstly and then decreased. Adsorption-desorption curve showed that relative pressure concentrated in 0. 8-1. 0 when condensation and evaporation occurred; Adsorption quantity of N 2 in sample was maximum after crushed 9 min,and it had significant differences with other samples. Conclusion: Pheretima could be crushed to micron level by vibration type low temperaturepulverization,low temperature pulverizationcould guarantee active ingredients in Pheretima unchanged,and it was not easy to gather after crushed to appropriate particle size,which reached particle design requirements of Pheretima in Xiaojin pills.
Objective: To investigate process parameters and powder characteristics of Pheretima after low temperature pulverization. Method: Pheretima was crushed again by vibration type low temperature ultrafine pulverizer after it was crushed to uniform particle size with high speed grinderof Chinese medicine,sampling every 3 min until all samples out of machine by 25 min,then particle size,specific surface area and porosity of samples were tested. Result: With increasing of grinding time,particle size decreased gradually,then particle size increased after agglomeration of particles; specific surface area and porosity increased firstly and then decreased. Adsorption-desorption curve showed that relative pressure concentrated in 0. 8-1. 0 when condensation and evaporation occurred; Adsorption quantity of N 2 in sample was maximum after crushed 9 min,and it had significant differences with other samples. Conclusion: Pheretima could be crushed to micron level by vibration type low temperaturepulverization,low temperature pulverizationcould guarantee active ingredients in Pheretima unchanged,and it was not easy to gather after crushed to appropriate particle size,which reached particle design requirements of Pheretima in Xiaojin pills.
引文
[1]平欲晖,宗星星,关志宇,等.HPLC测定小金丸中乌头碱的含量[J].中国实验方剂学杂志,2013,19(9):80.
[2]刘文雅,王曙东.地龙药理作用研究进展[J].中国中西医结合杂志,2013,33(2):282.
[3]杨明,韩丽,杨胜,等.基于传统丸、散剂特点的中药粒子设计技术研究[J].中草药,2012,43(1):9.
[4]杨丰云,付廷明,郭立玮,等.响应面分析法优化湿法超微粉碎地龙蛋白的提取工艺[J]中国实验方剂学杂志,2012,18(10):33.
[5]张瑜,范丙义,张大禄.超微粉碎技术在中药加工中的应用与思考[J].中国药学杂志,2002,37(11):801.
[6]陈金妹,谈萍,王建永.气体吸附法表征多孔材料的比表面积及孔结构[J].粉末冶金工业,2011,21(2):45.
[7]秦春凤,韩丽,张定堃,等.微粉硅胶研磨改性对白芷提取物性质的影响[J].中国药师,2013,16(1):9.
[8]蔡伟,陈兴莉,程小平,等.小金丸的安全性评价与合理使用[J].中国医院药学杂志,2013,33(10):819.
[9]李滔管涛,胡欣,等.小金丸不良反应报告19例分析[J].药物不良反应杂志,2005,7(3):223.
[10]张兆旺.中药药剂学[M].2版.北京:中国中医药出版社,2007:67.
[2]刘文雅,王曙东.地龙药理作用研究进展[J].中国中西医结合杂志,2013,33(2):282.
[3]杨明,韩丽,杨胜,等.基于传统丸、散剂特点的中药粒子设计技术研究[J].中草药,2012,43(1):9.
[4]杨丰云,付廷明,郭立玮,等.响应面分析法优化湿法超微粉碎地龙蛋白的提取工艺[J]中国实验方剂学杂志,2012,18(10):33.
[5]张瑜,范丙义,张大禄.超微粉碎技术在中药加工中的应用与思考[J].中国药学杂志,2002,37(11):801.
[6]陈金妹,谈萍,王建永.气体吸附法表征多孔材料的比表面积及孔结构[J].粉末冶金工业,2011,21(2):45.
[7]秦春凤,韩丽,张定堃,等.微粉硅胶研磨改性对白芷提取物性质的影响[J].中国药师,2013,16(1):9.
[8]蔡伟,陈兴莉,程小平,等.小金丸的安全性评价与合理使用[J].中国医院药学杂志,2013,33(10):819.
[9]李滔管涛,胡欣,等.小金丸不良反应报告19例分析[J].药物不良反应杂志,2005,7(3):223.
[10]张兆旺.中药药剂学[M].2版.北京:中国中医药出版社,2007:67.