摘要
[Objectives] To prepare and characterize a novel liver targeted drug carrier. [Methods] 6-O-acyl-D-galactose esters were enzymatically synthesized as a targeting molecule and incorporated into liposomes to prepare liposomal nanoparticles surface-modified with galactose. [Results] Liposomes were characterized by morphology, particle distribution size, zeta potential and encapsulating efficiency of drugs. [Conclusions] This novel approach for the liposomes surface-modifed with galactose by enzymatic synthesis is expected to provide potential application as drug carrier for active targeted delivery to hepatocytes.
[Objectives] To prepare and characterize a novel liver targeted drug carrier. [Methods] 6-O-acyl-D-galactose esters were enzymatically synthesized as a targeting molecule and incorporated into liposomes to prepare liposomal nanoparticles surface-modified with galactose. [Results] Liposomes were characterized by morphology, particle distribution size, zeta potential and encapsulating efficiency of drugs. [Conclusions] This novel approach for the liposomes surface-modifed with galactose by enzymatic synthesis is expected to provide potential application as drug carrier for active targeted delivery to hepatocytes.
引文
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