特络细胞及其胞外囊泡与细胞间交流
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摘要
特络细胞(telcocytes,TCs)是一种间质细胞,广泛存在于人和哺乳动物的许多器官和组织中。TCs是一种带有突起的细胞,通过同型连接、异型连接或释放细胞外囊泡直接参与细胞间交流。越来越多的证据表明,TCs可能是一种潜在的再生细胞。本文总结了TCs及其胞外囊泡参与细胞间交流的证据,并讨论了它们潜在的功能作用。TCs的研究为再生医学提供了新的见解,在未来可考虑利用TC_s作为新型靶细胞治疗相关疾病。
Telocytes(TCs) are a type of interstitial cells widely distributed in a variety of organs and tissue in humans and mammals. They are the cells with telopodes and are directly involved in intercellular communication through homo-and hetero-cellular junctions or by releasing extracellular vesicles. Evidence is accumulating which indicates that TCs might be potential regenerative cells.In this review, the data of TCs and their extracellular vesicles involve in intercellular communication is summarized, and their putative roles discussed. The research on TCs has provided new insights into regenerative medicine, and TCs may be usable as new target cells in the treatment of related diseases in the future.
Telocytes(TCs) are a type of interstitial cells widely distributed in a variety of organs and tissue in humans and mammals. They are the cells with telopodes and are directly involved in intercellular communication through homo-and hetero-cellular junctions or by releasing extracellular vesicles. Evidence is accumulating which indicates that TCs might be potential regenerative cells.In this review, the data of TCs and their extracellular vesicles involve in intercellular communication is summarized, and their putative roles discussed. The research on TCs has provided new insights into regenerative medicine, and TCs may be usable as new target cells in the treatment of related diseases in the future.
引文
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[11]Faussone-Pellegrini MS,Gherghiceanu M.Telocyte's contacts.Semin Cell Dev Biol,2016,55:3-8.
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[14]Song D,Cretoiu D,Zheng M,et al.Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types.J Cell Mol Med,2016,20(1):71-80.
[15]Zheng Y,Cretoiu D,Yan G,et al.Comparative proteomic analysis of human lung telocytes with fibroblasts.J Cell Mol Med,2014,18(4):568-589.
[16]Mandache E,Popescu LM,Gherghiceanu M.Myocardial interstitial Cajal-like cells(ICLC)and their nanostructural relationships with intercalated discs:shed vesicles as intermediates.J Cell Mol Med,2007,11(5):1175-1184.
[17]Cretoiu SM,Cretoiu D,Marin A,et al.Telocytes:ultrastructural,immunohistochemical and electrophysiological characteristics in human myometrium.Reproduction,2013,145(4):357-370.
[18]Ibba-Manneschi L,Rosa I,Manetti M.Telocyte implications in human pathology:An overview.Semin Cell Dev Biol,2016,55:62-69.
[19]Chang Y,Li C,Lu Z,et al.Multiple immunophenotypes of cardiac telocytes.Exp Cell Res,2015,338(2):239-244.
[20]Fertig ET,Gherghiceanu M,Popescu LM.Extracellular vesicles release by cardiac telocytes:electron microscopy and electron tomography.J Cell Mol Med,2014,18(10):1938-1943.
[21]Cismasiu VB,Radu E,Popescu LM.miR-193 expression differentiates telocytes from other stromal cells.J Cell Mol Med,2011,15(5):1071-1074.
[22]Albulescu R,Tanase C,Codrici E,et al.The secretome of myocardial telocytes modulates the activity of cardiac stem cells.J Cell Mol Med,2015,19(8):1783-1794.
[23]Zheng Y,Chen X,Qian M,et al.Human lung telocytescould promote the proliferation and angiogenesis of human pulmonary microvascular endothelial cells in vitro.Mol Cell Ther,2014,2:3.
[24]Li Y,Zhang X,Gao J,et al.Increased telocytes involved in the proliferation of vascular smooth muscle cells in rat carotid artery balloon injury.Sci China Life Sci,2016,59(7):678-85.
[2]Camussi G,Deregibus MC,Bruno S,et al.Exosomes/microvesicles as a mechanism of cell-to-cell communication.Kidney Int,2010,78(9):838-848.
[3]Cismasiu VB,Popescu LM.Telocytes transfer extracellular vesicles loaded with microRNAs to stem cells.J Cell Mol Med,2015,19(2):351-358.
[4]Machida T,Tomofuji T,Ekuni D,et al.MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging.Int JMol Sci,2015,16(9):21294-21309.
[5]Villarroya-Beltri C,Baixauli F,Gutierrez-Vazquez C,et al.Sorting it out:regulation of exosome loading.Semin Cancer Biol,2014,28:3-13.
[6]Lacroix R,Dignat-George F.Microparticles as a circulating source of procoagulant and fibrinolytic activities in the circulation.Thromb Res,2012,129(Suppl 2):S27-29.
[7]Osteikoetxea X,Nemeth A,Sodar BW,et al.Extracellular vesicles in cardiovascular disease:are they Jedi or Sith?.J Physiol,2016,594(11):2881-2894.
[8]Cretoiu SM,Popescu LM.Telocytes revisited.Biomol Concepts,2014,5(5):353-369.
[9]Bei Y,Wang F,Yang C,et al.Telocytes in regenerative medicine.J Cell Mol Med,2015,19(7):1441-1454.
[10]Cretoiu D,Gherghiceanu M,Hummel E,et al.FIB-SEM tomography of human skin telocytes and their extracellular vesicles.J Cell Mol Med,2015,19(4):714-722.
[11]Faussone-Pellegrini MS,Gherghiceanu M.Telocyte's contacts.Semin Cell Dev Biol,2016,55:3-8.
[12]Cretoiu SM,Cretoiu D,Popescu LM.Human myometriumthe ultrastructural 3D network of telocytes.J Cell Mol Med,2012,16(11):2844-2849.
[13]Zheng Y,Zhang M,Qian M,et al.Genetic comparison of mouse lung telocytes with mesenchymal stem cells and fibroblasts.J Cell Mol Med,2013,17(4):567-577.
[14]Song D,Cretoiu D,Zheng M,et al.Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types.J Cell Mol Med,2016,20(1):71-80.
[15]Zheng Y,Cretoiu D,Yan G,et al.Comparative proteomic analysis of human lung telocytes with fibroblasts.J Cell Mol Med,2014,18(4):568-589.
[16]Mandache E,Popescu LM,Gherghiceanu M.Myocardial interstitial Cajal-like cells(ICLC)and their nanostructural relationships with intercalated discs:shed vesicles as intermediates.J Cell Mol Med,2007,11(5):1175-1184.
[17]Cretoiu SM,Cretoiu D,Marin A,et al.Telocytes:ultrastructural,immunohistochemical and electrophysiological characteristics in human myometrium.Reproduction,2013,145(4):357-370.
[18]Ibba-Manneschi L,Rosa I,Manetti M.Telocyte implications in human pathology:An overview.Semin Cell Dev Biol,2016,55:62-69.
[19]Chang Y,Li C,Lu Z,et al.Multiple immunophenotypes of cardiac telocytes.Exp Cell Res,2015,338(2):239-244.
[20]Fertig ET,Gherghiceanu M,Popescu LM.Extracellular vesicles release by cardiac telocytes:electron microscopy and electron tomography.J Cell Mol Med,2014,18(10):1938-1943.
[21]Cismasiu VB,Radu E,Popescu LM.miR-193 expression differentiates telocytes from other stromal cells.J Cell Mol Med,2011,15(5):1071-1074.
[22]Albulescu R,Tanase C,Codrici E,et al.The secretome of myocardial telocytes modulates the activity of cardiac stem cells.J Cell Mol Med,2015,19(8):1783-1794.
[23]Zheng Y,Chen X,Qian M,et al.Human lung telocytescould promote the proliferation and angiogenesis of human pulmonary microvascular endothelial cells in vitro.Mol Cell Ther,2014,2:3.
[24]Li Y,Zhang X,Gao J,et al.Increased telocytes involved in the proliferation of vascular smooth muscle cells in rat carotid artery balloon injury.Sci China Life Sci,2016,59(7):678-85.