小胶质细胞与癫痫的关系研究进展
摘要
<正>癫痫是一种常见的神经系统疾病。目前,全球约有癫痫病人5 000万,我国约有900万,而且每年有40～50万的新发病人~([1])。反复的癫痫发作导致病人发育迟缓、认知障碍,以及精神行为异常等。癫痫病人不仅生活质量低下,而且死亡年龄比一般人群
引文
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[7] Kim M, Choi SY, Lee P, et al. Neochlorogenic acid inhibits lipopolysaccharide-induced activation and proinflammatory responses in BV2 microglial cells[J]. Neurochem Res,2015, 40(9):1792-1798.
[8] Tan H, Cao J, Zhang J, et al. Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats[J]. J Neuro Inflammation,2014, 4(11):93-103.
[9] Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blázquez M, et al. Transient P2X7 receptor antagonism produces lasting reductionsin spontaneous seizures and gliosisin experimental temporal lobe epilepsy[J]. J Neurosci, 2016,36(22):5920-5932.
[10] Gross A, Benninger F, Madar R, et al. Toll-like receptor deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice[J]. Epilepsia, 2017, 58(4):586-596.
[11] Coras R, Blümcke I. Clinico-pathological subtypes of hippocampal sclerosis in temporal lobe epilepsy and their differential impact on memory impairment[J]. Neuroscience, 2015, 309:153-161.
[12] Luo C, Ikegaya Y, Koyama R. Microglia and neurogenesis in the epileptic dentate gyrus[J]. Neurogenesis, 2016, 3(1):e1235525.
[13] Cattani AA, Allene C, Seifert V, et al. Involvement of MicroRNAs in epileptogenesis[J]. Epilepsia, 2016, 57(7):1015-1026.
[14] Cho KO, Lybrand ZR, Ito N, et al. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitivedecline[J]. Nat Commun, 2015, 6:6606.
[15] Luo C, Koyama R, Ikegaya Y. Microglia engulf viable newborn cells in the epileptic dentate gyrus[J]. Glia, 2016, 64(9):1508-1517.
[16] Cardenas-Rodriguez N, Huerta-Gertrudis B, RiveraEspinosa L, et al. Role of oxidative stress in refractory epilepsy:evidence in patients and experimental models[J].Int J Mol Sci, 2013, 14(1):1455-1476.
[17] Sorce S, Krause KH, Jaquet V. Targeting NOX enzymesin the central nervous system:therapeutic opportunities[J].Cell Mol Life Sci, 2012, 69(14):2387-2407.
[18] Guadagno J, Xu X, Karajgikar M, et al. Microglia-derived TNFαinduces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma[J]. Cell Death Dis, 2013, 4(3):e538.
[19] Schartz ND, Wyatt-Johnson SK, Price LR, et al. Status epilepticus triggerslong-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizurefrequency in experimental epilepsy[J]. Neurobiol Dis, 2018, 109(Pt A):163-173.
[20] Wyatt SK, Witt T, Barbaro NM, et al. Enhanced classical complementpathway activation and altered phagocytosis signaling molecules in human epilepsy[J]. Exp Neurol,2017, 295:184-193.
[21] Schafer DP, Stevens B. Phagocytic glial cells:sculpting syn aptic circuits in the developing nervous system[J]. Curr Opin Neurobiol, 2013, 23(6):1034-1040.
[22] Parkhurst CN, Yang G, Ninan I, et al. Microglia promote lea pendent synapse formation through brain-derived neurotrophic factor[J]. Cell, 2013, 155(7):1596-1609.
[23] Vainchtein ID, Chin G, Cho FS, et al. Astrocyte-derived interleukin-33 promotes microglial synapseengulfment and neural circuit development[J]. Science, 2018, 359(6381):1269-1273.
[2] Freeman LC, Ting JP.The pathogenic role of the inflammasome in neurodegenerativediseases[J]. J Neurochem, 2016,136(Suppl1):29-38.
[3] VezzaniA, LangB, Aronica E. Immunity and inflammation in epilepsy[J]. Cold Spring HarbPerspect Med, 2015, 6(2):a022699.
[4] Shaw JA, Perry VH, Mellanby. MHC classⅡexpression by microglia in tetanus toxin-induced experimental epilepsy in the rat[J]. NeuropatholAppl Neurobiol, 1994, 20(4):392-398.
[5] Lu JQ, Steve TA, Wheatley M, et al. Immune cell infiltrates in hippocampal sclerosis:correlation with neuronal loss[J].J Neuropathol Exp Neurol, 2017, 76(3):206-215.
[6] Pardo CA, Vining EP, Guo L, et al. The pathology of Rasmussen syndrome:stages of cortical involvement and neuropathological studies in 45 hemispherectomies[J].Epilepsia, 2010, 45(5):516-526.
[7] Kim M, Choi SY, Lee P, et al. Neochlorogenic acid inhibits lipopolysaccharide-induced activation and proinflammatory responses in BV2 microglial cells[J]. Neurochem Res,2015, 40(9):1792-1798.
[8] Tan H, Cao J, Zhang J, et al. Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats[J]. J Neuro Inflammation,2014, 4(11):93-103.
[9] Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blázquez M, et al. Transient P2X7 receptor antagonism produces lasting reductionsin spontaneous seizures and gliosisin experimental temporal lobe epilepsy[J]. J Neurosci, 2016,36(22):5920-5932.
[10] Gross A, Benninger F, Madar R, et al. Toll-like receptor deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice[J]. Epilepsia, 2017, 58(4):586-596.
[11] Coras R, Blümcke I. Clinico-pathological subtypes of hippocampal sclerosis in temporal lobe epilepsy and their differential impact on memory impairment[J]. Neuroscience, 2015, 309:153-161.
[12] Luo C, Ikegaya Y, Koyama R. Microglia and neurogenesis in the epileptic dentate gyrus[J]. Neurogenesis, 2016, 3(1):e1235525.
[13] Cattani AA, Allene C, Seifert V, et al. Involvement of MicroRNAs in epileptogenesis[J]. Epilepsia, 2016, 57(7):1015-1026.
[14] Cho KO, Lybrand ZR, Ito N, et al. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitivedecline[J]. Nat Commun, 2015, 6:6606.
[15] Luo C, Koyama R, Ikegaya Y. Microglia engulf viable newborn cells in the epileptic dentate gyrus[J]. Glia, 2016, 64(9):1508-1517.
[16] Cardenas-Rodriguez N, Huerta-Gertrudis B, RiveraEspinosa L, et al. Role of oxidative stress in refractory epilepsy:evidence in patients and experimental models[J].Int J Mol Sci, 2013, 14(1):1455-1476.
[17] Sorce S, Krause KH, Jaquet V. Targeting NOX enzymesin the central nervous system:therapeutic opportunities[J].Cell Mol Life Sci, 2012, 69(14):2387-2407.
[18] Guadagno J, Xu X, Karajgikar M, et al. Microglia-derived TNFαinduces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma[J]. Cell Death Dis, 2013, 4(3):e538.
[19] Schartz ND, Wyatt-Johnson SK, Price LR, et al. Status epilepticus triggerslong-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizurefrequency in experimental epilepsy[J]. Neurobiol Dis, 2018, 109(Pt A):163-173.
[20] Wyatt SK, Witt T, Barbaro NM, et al. Enhanced classical complementpathway activation and altered phagocytosis signaling molecules in human epilepsy[J]. Exp Neurol,2017, 295:184-193.
[21] Schafer DP, Stevens B. Phagocytic glial cells:sculpting syn aptic circuits in the developing nervous system[J]. Curr Opin Neurobiol, 2013, 23(6):1034-1040.
[22] Parkhurst CN, Yang G, Ninan I, et al. Microglia promote lea pendent synapse formation through brain-derived neurotrophic factor[J]. Cell, 2013, 155(7):1596-1609.
[23] Vainchtein ID, Chin G, Cho FS, et al. Astrocyte-derived interleukin-33 promotes microglial synapseengulfment and neural circuit development[J]. Science, 2018, 359(6381):1269-1273.