HPLC法测定无盐咪唑啉中丙烯酸含量
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摘要
采用高效液相色谱(HPLC)法测定无盐咪唑啉中丙烯酸的含量。结果表明,丙烯酸在9.09~77.27μg/mL与峰面积有良好的线性关系(r=0.999 5),该方法的检出限和定量限分别为0.1μg/mL和0.3μg/mL;精密度、重复性实验相对标准偏差(RSD)均小于2.0%。丙烯酸的平均加标回收率为90.99%,RSD为2.52%(n=9)。
The content of acrylic acid in salt-free imidazoline was determined by high performance liquid chromatography. The results showed that the linear range of acrylic acid was 9.09 ~ 77.27 μg/mL(r = 0.999 5), the LOD was 0.1 μg/mL and the LOQ was 0.3 μg/mL. The RSD of precision and reproducibility tests were both less than 2.0%. The average recovery of the acrylic acid was 90.99%,and the RSD was 2.52%(n=9).
The content of acrylic acid in salt-free imidazoline was determined by high performance liquid chromatography. The results showed that the linear range of acrylic acid was 9.09 ~ 77.27 μg/mL(r = 0.999 5), the LOD was 0.1 μg/mL and the LOQ was 0.3 μg/mL. The RSD of precision and reproducibility tests were both less than 2.0%. The average recovery of the acrylic acid was 90.99%,and the RSD was 2.52%(n=9).
引文
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[12]张斌,钱叶飞,闵春燕,等.超高效液相色谱法同时测定化妆品中7种美白成分[J].日用化学工业,2016,46(2):118-122.
[2]马丽娜,杨庆利,王丰收,等.烷基糖苷与辛基咪唑啉复配体系的性能研究[J].日用化学工业,2015,45(10):561-563.
[3]陆建雄,冯光炷,陈深龙,等.咪唑啉型表面活性剂的合成研究进展[J].广东化工,2012,39(2):92-93.
[4]王杰,闫小伟,周占胜,等.咪唑啉两性Gemini表面活性剂的合成及性能研究[J].海南师范大学学报(自然科学版),2012,4:415-420.
[5]郭建龙.羧酸型咪唑啉两性表面活性剂的合成与性能研究[D].天津理工大学,2008.
[6]梁梦兰,安碧城.两性咪唑啉表面活性剂的合成与应用[J].精细石油化工,1986,5:14-28.
[7]郑彤,华慢,黄建邦.无盐咪唑啉两性表面活性剂的合成及性能研究[J].日用化学品科学,2011,34(2):27-29,43.
[8]WREN SA,TCHELIT P.Use of ultra-performance liquid chromatography in pharmaceutical development[J].J Chromatography A,2006,1119(1-2):140-145.
[9]王文琼.超高液相在药物分析领域中的应用[J].中国医药导报,2012,9(11):13-14.
[10]王冬,周健鹏,王晨.HPLC法测定甲基丙烯酸-丙烯酸乙酯共聚物中有关物质的含量[J].中国药房,2015,26(24):3436-3438.
[11]毕晓黎,罗文汇,胥爱丽,等.超高液相色谱法测定白芷配方颗粒中欧前胡素和异欧前胡素的含量[J].中国实验方剂学杂志,2012,18(10):140-142.
[12]张斌,钱叶飞,闵春燕,等.超高效液相色谱法同时测定化妆品中7种美白成分[J].日用化学工业,2016,46(2):118-122.