胰岛细胞抗体和胰岛素自身抗体与急性病毒感染的相关性及其临床应用
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摘要
目的探究免疫球蛋白G-胰岛细胞抗体(immunoglobulin G-islet cell antibodies,Ig G-ICA)和免疫球蛋白M-胰岛素自身抗体(immunoglobulin M-insulin autoantibody,Ig M-IAA)与急性病毒感染的相关性及其临床应用价值。方法回顾性分析2016年8月至2018年3月北京中医药大学东方医院收治的70例急性病毒感染患者的病例资料,并将其作为研究组,以同期无糖尿病且无感染性疾病的70例健康体检者作为对照组。两组均在空腹条件下取静脉血,检测两组受试者的糖脂代谢情况,补体结合胰岛细胞抗体(islet tibodies,CF-ICA)、Ig G-ICA阳性检出率,胃壁细胞抗体、甲状腺微粒抗体以及Ig M-IAA和Ig G-IAA的阳性检出率。结果两组受试者的血糖及血脂水平差异无显著性(P>0.05)。研究组Ig G-ICA、CF-ICA、Ig M-IAA、Ig G-IAA阳性检出率均显著高于对照组(P<0.05),检出胃壁细胞抗体及甲状腺微粒抗体的例数显著多于对照组(P<0.05)。结论急性病毒感染后患者血清中的IAA水平升高,以Ig M-IAA升高最为显著,推测Ig M-IAA的产生可能与病毒感染涉及免疫细胞激活的机制有关。
Objective To explore the relationship between immunoglobulin G-islet cell antibodies(IgG-ICA), immunoglobulin M-insulin autoantibody(IgM-IAA) and acute viral infection, and explore their clinical application value. Method From August 2016 to March 2018, 70 samples of patients with acute viral infection in the Oriental Hospital of Beijing University of traditional Chinese Medicine were collected as the study group, and samples of 70 physical examiners without diabetic and infectious diseases at the same time were collected as the control group. Venous blood samples were taken from the two groups of subjects on an empty stomach. Blood glucose and lipid metabolism, complement fixing islet cell antibodies(CF-ICA), positive detection rate of IgG-ICA, gastric parietal cell antibodies, the positive detection rates of thyroid particle antibodies, IgM-IAA and IgG-IAA were detected in the two groups. Result The blood glucose and blood lipid levels were normal in both groups, and there was no significant difference between the two groups(P>0.05). The positive detection rates of IgG-ICA, CF-ICA, IgM-IAA, IgG-IAA in the study group were significantly higher than that in the control group(P< 0.05), and the cases of gastric parietal cell antibodies and thyroid particle antibodies were significantly higher than those in the control group(P<0.05). Conclusion The level of IAA in serum of patients was increased after acute viral infection, and the increase of IgM-IAA was the most significant. It is speculated that the production of IgM-IAA may be related to the mechanism of viral infection involves activation of immune cells.
Objective To explore the relationship between immunoglobulin G-islet cell antibodies(IgG-ICA), immunoglobulin M-insulin autoantibody(IgM-IAA) and acute viral infection, and explore their clinical application value. Method From August 2016 to March 2018, 70 samples of patients with acute viral infection in the Oriental Hospital of Beijing University of traditional Chinese Medicine were collected as the study group, and samples of 70 physical examiners without diabetic and infectious diseases at the same time were collected as the control group. Venous blood samples were taken from the two groups of subjects on an empty stomach. Blood glucose and lipid metabolism, complement fixing islet cell antibodies(CF-ICA), positive detection rate of IgG-ICA, gastric parietal cell antibodies, the positive detection rates of thyroid particle antibodies, IgM-IAA and IgG-IAA were detected in the two groups. Result The blood glucose and blood lipid levels were normal in both groups, and there was no significant difference between the two groups(P>0.05). The positive detection rates of IgG-ICA, CF-ICA, IgM-IAA, IgG-IAA in the study group were significantly higher than that in the control group(P< 0.05), and the cases of gastric parietal cell antibodies and thyroid particle antibodies were significantly higher than those in the control group(P<0.05). Conclusion The level of IAA in serum of patients was increased after acute viral infection, and the increase of IgM-IAA was the most significant. It is speculated that the production of IgM-IAA may be related to the mechanism of viral infection involves activation of immune cells.
引文
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[11]冯希云,任艳杰,赵跃斌,等.胰岛自身抗体与抗内皮细胞抗体在糖尿病中的研究进展[J].中国药物与临床,2016,16(7):1009-1010.
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[14]赵鸿斌,祁洁,李彦青.锌转运蛋白8抗体阳性的1型糖尿病患者胰岛自身抗体阳性率及生化指标水平[J].广西医学,2018,45(13):96-97.
[15]Pastore MR,Bazzigaluppi E,Belloni C,et al.Six months of gluten-free diet do not influence autoantibody titers,but improve insulin secretion in subjects at high risk for type 1 diabetes[J].JClin Endocrinol Metab,2016,88(1):162-165.
[16]卢建强,王伟佳,黄秋洪.胰岛自身抗体及生化指标在成人隐匿性自身免疫性糖尿病诊断中的应用[J].国际检验医学杂志,2018,74(2):238-240.
[17]Young OK,Hee KY,Yang EM,et al.Frequency of diabetes and thyroid autoantibodies in patients with type 1 diabetes and their siblings[J].Chonnam Med J,2016,52(2):136-140.
[18]钱鹏.2型糖尿病患者胰岛自身抗体阳性分布及C肽和相关生化指标的变化[J].检验医学,2016,31(1):9-12.
[19]苏冬雪.成人隐匿性自身免疫性糖尿病(LADA)自身免疫性抗体诊断效能的meta分析[D].长春:吉林大学,2017.
[2]陈飞,刘瑶,苟小军.生活方式、二甲双胍及罗格列酮早期干预成人隐匿性自身免疫性糖尿病患者的糖调节受损且胰岛自身抗体阳性同胞的保护效应研究[J].实用药物与临床,2016,19(10):1239-1243.
[3]Adejumo BI,Dimkpa U,Ewenighi CO,et al.The risk of islet cell and insulin autoantibodies and their predictive strength as markers of type-1 diabetes in a cross-section of nigerian population[J].Health,2016,8(12):1223-1233.
[4]梁启峰.妊娠期高血糖患者母体胰岛β细胞自身抗体对新生儿的影响[J].广州医药,2017,48(1):81-84.
[5]钱莉,杨涛,姜惠,等.1型糖尿病胰岛自身抗体与胰岛功能的关系[J].中华临床医师杂志(电子版),2017,11(5):728-733.
[6]赖建铭,黄小兰,周志轩,等.儿童红斑狼疮中糖尿病相关自身抗体检测意义[J].中华检验医学杂志,2016,39(11):829-832.
[7]王娜,邢小燕,陈晓平,等.以糖尿病为首发症状的IgG4相关性自身免疫胰腺炎一例并文献复习[J].中国糖尿病杂志,2016,8(7):414-417.
[8]阮鑫丹.胰岛自身抗体检测在成人隐匿性自身免疫糖尿病中的诊断价值[J].中国生化药物杂志,2017,85(12):404-405.
[9]刘发河,黎景梨,萧飞,等.糖尿病患者自身抗体联合检测的临床价值[J].检验医学,2016,14(b11):17-18.
[10]邹婧.自身免疫性糖尿病和甲状腺疾病患者特异性自身抗体水平及基因多态性相关性分析[D].长春:吉林大学,2016.
[11]冯希云,任艳杰,赵跃斌,等.胰岛自身抗体与抗内皮细胞抗体在糖尿病中的研究进展[J].中国药物与临床,2016,16(7):1009-1010.
[12]Awadalla SA,Al-Hakbani M.The predictive value of diabetesrelated antibodies in children with type 1 diabetes mellitus and their siblings[J].Int J Diabetes Dev Ctries,2016,37(3):1-6.
[13]何睢.四种自身抗体在1型糖尿病检测中的应用[J].医学信息,2016,29(1):347-348.
[14]赵鸿斌,祁洁,李彦青.锌转运蛋白8抗体阳性的1型糖尿病患者胰岛自身抗体阳性率及生化指标水平[J].广西医学,2018,45(13):96-97.
[15]Pastore MR,Bazzigaluppi E,Belloni C,et al.Six months of gluten-free diet do not influence autoantibody titers,but improve insulin secretion in subjects at high risk for type 1 diabetes[J].JClin Endocrinol Metab,2016,88(1):162-165.
[16]卢建强,王伟佳,黄秋洪.胰岛自身抗体及生化指标在成人隐匿性自身免疫性糖尿病诊断中的应用[J].国际检验医学杂志,2018,74(2):238-240.
[17]Young OK,Hee KY,Yang EM,et al.Frequency of diabetes and thyroid autoantibodies in patients with type 1 diabetes and their siblings[J].Chonnam Med J,2016,52(2):136-140.
[18]钱鹏.2型糖尿病患者胰岛自身抗体阳性分布及C肽和相关生化指标的变化[J].检验医学,2016,31(1):9-12.
[19]苏冬雪.成人隐匿性自身免疫性糖尿病(LADA)自身免疫性抗体诊断效能的meta分析[D].长春:吉林大学,2017.