近红外光谱法同时检测复方卡托普利片中卡托普利和氢氯噻嗪的含量
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摘要
以高效液相色谱测定出的复方卡托普利片中卡托普利和氢氯噻嗪的含量为标准,将化学计量学与近红外光谱技术相结合,分别建立复方卡托普利药片和药粉的定量分析模型。对药片模型和药粉模型的预测结果进行了比较,结果表明,药粉模型预测结果的准确度略优于药片模型。本方法操作简单,实验结果准确可靠,可同时快速检测复方卡托普利片中卡托普利和氢氯噻嗪的含量。
The content of captopril and hydrochlorothiazide in compound captopril tablets was determined by HPLC. The quantitative analysis model of compound captopril tablets and powders was established by combining chemometrics with near-infrared spectroscopy. The prediction results of the tablet model and the powder model were compared. The results showed that accuracy of the prediction results of the powder model was slightly better than the tablet model. The method of operation was simple, the test result was accurate and reliable, and the content of captopril and hydrochlorothiazide in the compound captopril tablet could be quickly detected at the same time.
The content of captopril and hydrochlorothiazide in compound captopril tablets was determined by HPLC. The quantitative analysis model of compound captopril tablets and powders was established by combining chemometrics with near-infrared spectroscopy. The prediction results of the tablet model and the powder model were compared. The results showed that accuracy of the prediction results of the powder model was slightly better than the tablet model. The method of operation was simple, the test result was accurate and reliable, and the content of captopril and hydrochlorothiazide in the compound captopril tablet could be quickly detected at the same time.
引文
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[6]孙宗保,辛新,邹小波,等.傅里叶变换红外光谱结合化学计量学方法对白酒基酒的快速定性和定量分析[J].光谱学与光谱分析,2017,37(9):2756-2762.
[7]李方飞,彭应枝,许雄博,等.近红外光谱技术结合化学计量学快速测定杜仲中松脂素二葡萄糖苷和京尼平苷酸的含量[J].光谱学与光谱分析,2016,36(12):3945-3950.
[8]周密,柯剑,李宝丽,等.傅里叶变换红外光谱结合化学计量学鉴别预包装纯菠萝汁中外源糖[J].光谱学与光谱分析,2015,35(10):2734-2739.
[9]沈乐丞,刘书航,邓海玲,等.近红外光谱结合偏最小二乘法快速测定糖果中水分含量[J].食品工业科技,2018,39(7):255-258.
[2]周修森,李道明,胡守莲,等.高效液相色谱法测定复方卡托普利片剂的含量[J].中南药学,2006(6):432-434.
[3]黄滔敏,刘振,沈丽萍,等.卡托普利片含量及有关物质测定方法[J].复旦学报(医学版),2004(4):429-431.
[4]高娟,唐素芳,高立勤,等.近红外光谱法快速分析卡托普利片中卡托普利的含量[J].天津药学,2010,22(1):9-11.
[5]黄海,武洋.近红外光谱法快速测定卡托普利片的含量[J].中国药事,2011,25(7):695-697.
[6]孙宗保,辛新,邹小波,等.傅里叶变换红外光谱结合化学计量学方法对白酒基酒的快速定性和定量分析[J].光谱学与光谱分析,2017,37(9):2756-2762.
[7]李方飞,彭应枝,许雄博,等.近红外光谱技术结合化学计量学快速测定杜仲中松脂素二葡萄糖苷和京尼平苷酸的含量[J].光谱学与光谱分析,2016,36(12):3945-3950.
[8]周密,柯剑,李宝丽,等.傅里叶变换红外光谱结合化学计量学鉴别预包装纯菠萝汁中外源糖[J].光谱学与光谱分析,2015,35(10):2734-2739.
[9]沈乐丞,刘书航,邓海玲,等.近红外光谱结合偏最小二乘法快速测定糖果中水分含量[J].食品工业科技,2018,39(7):255-258.