中波高能紫外线联合复方卡力孜然酊治疗白癜风疗效观察
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摘要
目的:观察中波高能紫外线联合复方卡力孜然酊治疗白癜风的疗效及安全性。方法:将105例白癜风患者随机分为3组。A组予304 nm中波高能紫外线照射联合外用复方卡力孜然酊,B组单用304 nm中波高能紫外线照射,C组仅外用复方卡力孜然酊。3组患者疗程均为12周,治疗结束后比较3组疗效。结果:共97例患者完成治疗和随访。12周后,A、B、C各组患者靶皮损有效率分别为84.55%、51.51%和50.00%。A组与B、C组有效率比较,差异均有统计学意义(P均<0.05)。结论:中波高能紫外线联合复方卡力孜然酊是治疗白癜风安全及有效的方法。
Objective: To investigate the efficacy and safety of 304 nm high-energy UVB combined with compound kaliziran tincture for vitiligo. Methods: A total of 105 patients with vitiligo were randomly divided into three groups(A, B and C group). Group A was treated with 304 nm UVB combined with compound kaliziran tincture for 12 weeks, while groups B and C were treated with 304 nm UVB and compounf kaliziran tincture, respectively. Results: A total of 97 patients completed treatment and follow-up. After 12 weeks of treatments, the effective rates in groups A, B and C were 84.55%, 51.51%and50.00%, respectively(P<0.05, group A vs. both B and C). Conclusion: Combination therapy of 304 nm high-energy UVB and compound kaliziran tincture is effective and safe for vitiligo.
Objective: To investigate the efficacy and safety of 304 nm high-energy UVB combined with compound kaliziran tincture for vitiligo. Methods: A total of 105 patients with vitiligo were randomly divided into three groups(A, B and C group). Group A was treated with 304 nm UVB combined with compound kaliziran tincture for 12 weeks, while groups B and C were treated with 304 nm UVB and compounf kaliziran tincture, respectively. Results: A total of 97 patients completed treatment and follow-up. After 12 weeks of treatments, the effective rates in groups A, B and C were 84.55%, 51.51%and50.00%, respectively(P<0.05, group A vs. both B and C). Conclusion: Combination therapy of 304 nm high-energy UVB and compound kaliziran tincture is effective and safe for vitiligo.
引文
[1]杨慧兰,李翠华,李雪梅,等.白癜风的治疗现状与进展[J].中国美容医学杂志,2006,15(1):93-95.
[2]中国中西医结合学会皮肤性病专业委员会色素病学组.黄褐斑和白癜风的诊疗标准(2010年版)[J].中华皮肤科杂志,2010,43(6):373.
[3]霍培文,陈建华,廖家,等.中波高能紫外光治疗白癜风疗效与影响因素分析[J].中国美容医学杂志,2013,22(6):651-654.
[4]宋秀祖,樊奇敏,胡慧丽,等.308 nm准分子光照射身体不同部位产生最小红斑量的比较[J].国际皮肤性病学杂志,2006,32(5):267-269.
[5]胡佳,杨莉佳,曹蕾.高能中波紫外线治疗寻常型白癜风的临床疗效观察[J].中华皮肤科杂志,2011,44(1):58-59.
[6]Scherschun L,Kim JJ,Lim HW.Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo[J].J Am Acad Dermatol,2001,44(6):999-1003.
[7]Lotti T,Gori A,Zanieri F,et a1.Vitiligo:new and emerging treatments[J].Dermatol Ther,2008,21(2):110-117.
[8]Hirobe T.Role of keratinocyle-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes[J].Pigment Cell Res,2005,18(1):2-12.
[9]董秀芹,刘涛,肖洁平,等.中波高能紫外线照射治疗白癜风疗效观察[J].中国美容医学杂志,2010,19(8):1173-1176.
[10]吴文育,杨勤萍,陈美娟,等.复方卡力孜然酊治疗白癜风[J].中华皮肤科杂志,2005,38(4):250.
[11]李河山,李坤.复方卡力孜然酊治疗白癜风疗效观察[J].临床皮肤科杂志,2008,37(2):128.
[12]韩庆东,张建平,胡佳圆,等.窄谱中波紫外线联合复方卡力孜然酊治疗白癜风79例[J].中华皮肤科杂志,2010,43(9):653.
[13]张晓冬,林涛生,张艳.窄谱中波紫外线联合复方卡力孜然酊治疗白癜风临床疗效观察[J].临床皮肤科杂志,2015,44(7):457-458.
[14]杨慧兰,刘仲荣.308 nm准分子激光治疗白癜风临床研究[J].中华皮肤科杂志,2006,39(1):35-37.
[2]中国中西医结合学会皮肤性病专业委员会色素病学组.黄褐斑和白癜风的诊疗标准(2010年版)[J].中华皮肤科杂志,2010,43(6):373.
[3]霍培文,陈建华,廖家,等.中波高能紫外光治疗白癜风疗效与影响因素分析[J].中国美容医学杂志,2013,22(6):651-654.
[4]宋秀祖,樊奇敏,胡慧丽,等.308 nm准分子光照射身体不同部位产生最小红斑量的比较[J].国际皮肤性病学杂志,2006,32(5):267-269.
[5]胡佳,杨莉佳,曹蕾.高能中波紫外线治疗寻常型白癜风的临床疗效观察[J].中华皮肤科杂志,2011,44(1):58-59.
[6]Scherschun L,Kim JJ,Lim HW.Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo[J].J Am Acad Dermatol,2001,44(6):999-1003.
[7]Lotti T,Gori A,Zanieri F,et a1.Vitiligo:new and emerging treatments[J].Dermatol Ther,2008,21(2):110-117.
[8]Hirobe T.Role of keratinocyle-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes[J].Pigment Cell Res,2005,18(1):2-12.
[9]董秀芹,刘涛,肖洁平,等.中波高能紫外线照射治疗白癜风疗效观察[J].中国美容医学杂志,2010,19(8):1173-1176.
[10]吴文育,杨勤萍,陈美娟,等.复方卡力孜然酊治疗白癜风[J].中华皮肤科杂志,2005,38(4):250.
[11]李河山,李坤.复方卡力孜然酊治疗白癜风疗效观察[J].临床皮肤科杂志,2008,37(2):128.
[12]韩庆东,张建平,胡佳圆,等.窄谱中波紫外线联合复方卡力孜然酊治疗白癜风79例[J].中华皮肤科杂志,2010,43(9):653.
[13]张晓冬,林涛生,张艳.窄谱中波紫外线联合复方卡力孜然酊治疗白癜风临床疗效观察[J].临床皮肤科杂志,2015,44(7):457-458.
[14]杨慧兰,刘仲荣.308 nm准分子激光治疗白癜风临床研究[J].中华皮肤科杂志,2006,39(1):35-37.