硫酸庆大霉素临床药效学研究进展
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摘要
硫酸庆大霉素是兽医临床治疗中较为安全的抗生素之一,其抗菌机理是通过影响细菌蛋白质合成从而产生抗菌作用。近年来,硫酸庆大霉素兽用药物制剂开发的种类较多,临床应用也日趋广泛。通过检索、查阅国内外文献,对硫酸庆大霉素药理作用和临床应用作一综述,以期为科学合理使用该药物提供参考。
Gentamicin sulfate is one of the safer antibiotics in the clinical veterinary. Its antibacterial mechanism is to interfere the bacterial protein synthesis. In recent year, many kinds of veterinary pharmaceuticals of gentamicin sulfare are developed, and their clinical applications are increasingly widespread. In this paper, the pharmacological action and clinical application of gentamicin sulfate was reviewed by searching and consulting the literature at home and abroad, in hoping to provide reference for scientific and prudent use of gentamicin sulfate.
Gentamicin sulfate is one of the safer antibiotics in the clinical veterinary. Its antibacterial mechanism is to interfere the bacterial protein synthesis. In recent year, many kinds of veterinary pharmaceuticals of gentamicin sulfare are developed, and their clinical applications are increasingly widespread. In this paper, the pharmacological action and clinical application of gentamicin sulfate was reviewed by searching and consulting the literature at home and abroad, in hoping to provide reference for scientific and prudent use of gentamicin sulfate.
引文
[1]AVENT M L,ROGERS B A,Cheng A C,et al.Current use of aminoglycosides:indications,pharmacokinetics and monitoring for toxicity[J].Internal Medicine Journal,2011,41(6):441-449.
[2]陈杖榴,曾振灵.兽医药理学[M].北京:中国农业出版社,2016.
[3]VAN DER BIJL P.Aminoglycoside monitoring:perspective on current trends in the Western Cape[J].South African Medical Journal,2005,95(7):474-477.
[4]YOU X F,LI C R,YANG X Y,et al.In vivo antibacterial activity of vertilmicin,a new aminoglycoside[J].Antibiotic Antimicrobial Agents and Chemotherapy,2009,53(10):4525-4528.
[5]CAMPBELL B G,BARTHOLOW S,ROSIN E.Bacterial killing by use of once daily gentamicin dosage in guinea pigs with Escherichia coli infection[J].American Journal of Veterinary Research,1996,57(11):1627-1630.
[6]ALBARELLOS G,MONTIYA L,AMBROS L,et al.Multiple once-daily dose pharmacokinetics and renal safety of gentamicin in dogs[J].Journal of Veterinary Pharmacology and Therapeutics,2004,27(1):21-25.
[7]GEOR R J,PAPICH,M G.Once-daily aminoglycoside dosing regimens[J].Current Therapy in Equine Medicine,2003(11):850-853.
[8]左儒楠,刘筱,王稚倩,等.复方庆大霉素注射液的质量控制及体外抑菌效果[J].中国兽医科学,2018,48(5):649-657.
[9]彭君茹.复方庆大霉素颗粒剂的质量控制及药效学研究[D].杨凌:西北农林科技大学,2017.
[10]宋雪娇,刘耀川,高翔,等.木犀草素联合庆大霉素对耐药化脓隐秘杆菌抑制作用的研究[J].中国兽药杂志,2016,50(11):54-58.
[11]王艳雯.纳米材料与抗生素联合作用的抗菌性能及机制研究[D].上海:上海大学,2015.
[12]徐刚,李晓云,王敏,等.盐酸林可霉素和硫酸庆大霉素对猪链球菌体外联合抗菌试验[J].中国兽医杂志,2010,46(7):70-73.
[13]张桂荣.猪源金黄色葡萄球菌的分离鉴定及药物敏感性分析[J].黑龙江畜牧兽医,2011(10):77-78.
[14]杨芳芳.鸭疫里默氏杆菌氨基糖苷类和喹诺酮类耐药基因的检测与序列分析[D].泰安:山东农业大学,2013.
[15]贾博岩.牛支原体对氟喹诺酮及氨基糖苷类抗生素耐药机制的初步研究[D].长春:吉林农业大学,2017.
[16]母海钵.基于氨基糖苷类抗生素的抗细菌生物膜和胞内寄生菌的药物设计和活性评价[D].杨凌:西北农林科技大学,2016.
[17]柏云江,田晓玲.复方庆大霉素可溶性粉防治鸡大肠杆菌病的研究[J].现代畜牧兽医,2005(5):40-41.
[18]周小宁,祁先鹏.鸡传染性鼻炎的实验室检查与防控措施[J].浙江畜牧兽医,2016,41(3):33-34.
[19]措毛吉.庆大霉素对雏鸡腹泻病的预防试验[J].中国畜牧兽医文摘,2013,29(7):190.
[20]陈英,高桂分.鸡大肠杆菌继发葡萄球菌性关节炎的诊断及防制[J].中国动物保健,2003(2):58.
[21]李绍行,唐式校.庆大霉素治疗鸭葡萄球菌病的疗效观察[J].现代畜牧科技,2010(12):137-138.
[22]尹会方,池圣清,黄伟斌.硫酸庆大霉素与百球清预防哺乳仔猪腹泻效果观察[J].湖北畜牧兽医,2013,34(4):15-17.
[23]黄其春,沈建勇.焦米汤结合口服补液对初生仔猪细菌性腹泻的治疗效果[J].江苏农业科学,2014,42(6):173-174.
[24]陆晓,刘娟,张俊,等.猪肺炎型链球菌病的诊治[J].中国畜牧兽医文摘,2014,30(1):141.
[25]傅军科,张辉,孙延鸣.rboGM-CSF结合庆大霉素治疗奶牛隐性乳房炎试验[J].西北农业学报,2010,19(1):26-29.
[26]汪小强.犊牦牛硫酸庆大霉素口服凝胶止泻剂的研制[D].武汉:华中农业大学,2016.
[27]肖银.庆大霉素在羊异物性气管炎治疗中的应用[J].吉林农业,2018(14):76.
[28]祁鹤民.穴位注射庆大霉素治疗牛羊关节炎[J].青海畜牧兽医杂志,2006,36(6):44.
[29]王全福.羔羊腹泻的病因及防治措施[J].动物医学,2017,47(1):89,91.
[30]陈棚岗,余老三,张小双,等.一起牛霉菌性肠炎的综合防治体会[J].中国畜禽业,2011,7(9):101.
[31]张玉棠,王福财,张海霞.高寒地区牦牛胃寒吐草症的治疗[J].中国牛业科学,2013,39(4):93-94.
[32]曹立亭,彭诗,彭代国,等.补中益气丸与硫酸庆大霉素治疗犬脾虚泄泻证的比较研究[J].西南大学学报(自然科学版),2016,38(3):25-28.
[33]宋丙潭,李玉明,于兴泉,等.猫抓病10例临床分析[J].滨州医学院学报,2010,33(5):395-396.
[34]宋海军.一例犬出血性胃肠炎的诊治[J].当代畜牧,2013(10):51.
[35]李中习.猫传染性肠炎防治[J].四川畜牧兽医,2017,44(1):42.
[36]陈旭,齐洁,张琛茜,等.貂出血性肺炎的诊断和治疗[J].畜牧兽医科技信息,2018(1):121.
[37]卢仲春.用庆大霉素治疗牛蛙脱肛病[J].猪业观察,1998(4):22.
[2]陈杖榴,曾振灵.兽医药理学[M].北京:中国农业出版社,2016.
[3]VAN DER BIJL P.Aminoglycoside monitoring:perspective on current trends in the Western Cape[J].South African Medical Journal,2005,95(7):474-477.
[4]YOU X F,LI C R,YANG X Y,et al.In vivo antibacterial activity of vertilmicin,a new aminoglycoside[J].Antibiotic Antimicrobial Agents and Chemotherapy,2009,53(10):4525-4528.
[5]CAMPBELL B G,BARTHOLOW S,ROSIN E.Bacterial killing by use of once daily gentamicin dosage in guinea pigs with Escherichia coli infection[J].American Journal of Veterinary Research,1996,57(11):1627-1630.
[6]ALBARELLOS G,MONTIYA L,AMBROS L,et al.Multiple once-daily dose pharmacokinetics and renal safety of gentamicin in dogs[J].Journal of Veterinary Pharmacology and Therapeutics,2004,27(1):21-25.
[7]GEOR R J,PAPICH,M G.Once-daily aminoglycoside dosing regimens[J].Current Therapy in Equine Medicine,2003(11):850-853.
[8]左儒楠,刘筱,王稚倩,等.复方庆大霉素注射液的质量控制及体外抑菌效果[J].中国兽医科学,2018,48(5):649-657.
[9]彭君茹.复方庆大霉素颗粒剂的质量控制及药效学研究[D].杨凌:西北农林科技大学,2017.
[10]宋雪娇,刘耀川,高翔,等.木犀草素联合庆大霉素对耐药化脓隐秘杆菌抑制作用的研究[J].中国兽药杂志,2016,50(11):54-58.
[11]王艳雯.纳米材料与抗生素联合作用的抗菌性能及机制研究[D].上海:上海大学,2015.
[12]徐刚,李晓云,王敏,等.盐酸林可霉素和硫酸庆大霉素对猪链球菌体外联合抗菌试验[J].中国兽医杂志,2010,46(7):70-73.
[13]张桂荣.猪源金黄色葡萄球菌的分离鉴定及药物敏感性分析[J].黑龙江畜牧兽医,2011(10):77-78.
[14]杨芳芳.鸭疫里默氏杆菌氨基糖苷类和喹诺酮类耐药基因的检测与序列分析[D].泰安:山东农业大学,2013.
[15]贾博岩.牛支原体对氟喹诺酮及氨基糖苷类抗生素耐药机制的初步研究[D].长春:吉林农业大学,2017.
[16]母海钵.基于氨基糖苷类抗生素的抗细菌生物膜和胞内寄生菌的药物设计和活性评价[D].杨凌:西北农林科技大学,2016.
[17]柏云江,田晓玲.复方庆大霉素可溶性粉防治鸡大肠杆菌病的研究[J].现代畜牧兽医,2005(5):40-41.
[18]周小宁,祁先鹏.鸡传染性鼻炎的实验室检查与防控措施[J].浙江畜牧兽医,2016,41(3):33-34.
[19]措毛吉.庆大霉素对雏鸡腹泻病的预防试验[J].中国畜牧兽医文摘,2013,29(7):190.
[20]陈英,高桂分.鸡大肠杆菌继发葡萄球菌性关节炎的诊断及防制[J].中国动物保健,2003(2):58.
[21]李绍行,唐式校.庆大霉素治疗鸭葡萄球菌病的疗效观察[J].现代畜牧科技,2010(12):137-138.
[22]尹会方,池圣清,黄伟斌.硫酸庆大霉素与百球清预防哺乳仔猪腹泻效果观察[J].湖北畜牧兽医,2013,34(4):15-17.
[23]黄其春,沈建勇.焦米汤结合口服补液对初生仔猪细菌性腹泻的治疗效果[J].江苏农业科学,2014,42(6):173-174.
[24]陆晓,刘娟,张俊,等.猪肺炎型链球菌病的诊治[J].中国畜牧兽医文摘,2014,30(1):141.
[25]傅军科,张辉,孙延鸣.rboGM-CSF结合庆大霉素治疗奶牛隐性乳房炎试验[J].西北农业学报,2010,19(1):26-29.
[26]汪小强.犊牦牛硫酸庆大霉素口服凝胶止泻剂的研制[D].武汉:华中农业大学,2016.
[27]肖银.庆大霉素在羊异物性气管炎治疗中的应用[J].吉林农业,2018(14):76.
[28]祁鹤民.穴位注射庆大霉素治疗牛羊关节炎[J].青海畜牧兽医杂志,2006,36(6):44.
[29]王全福.羔羊腹泻的病因及防治措施[J].动物医学,2017,47(1):89,91.
[30]陈棚岗,余老三,张小双,等.一起牛霉菌性肠炎的综合防治体会[J].中国畜禽业,2011,7(9):101.
[31]张玉棠,王福财,张海霞.高寒地区牦牛胃寒吐草症的治疗[J].中国牛业科学,2013,39(4):93-94.
[32]曹立亭,彭诗,彭代国,等.补中益气丸与硫酸庆大霉素治疗犬脾虚泄泻证的比较研究[J].西南大学学报(自然科学版),2016,38(3):25-28.
[33]宋丙潭,李玉明,于兴泉,等.猫抓病10例临床分析[J].滨州医学院学报,2010,33(5):395-396.
[34]宋海军.一例犬出血性胃肠炎的诊治[J].当代畜牧,2013(10):51.
[35]李中习.猫传染性肠炎防治[J].四川畜牧兽医,2017,44(1):42.
[36]陈旭,齐洁,张琛茜,等.貂出血性肺炎的诊断和治疗[J].畜牧兽医科技信息,2018(1):121.
[37]卢仲春.用庆大霉素治疗牛蛙脱肛病[J].猪业观察,1998(4):22.