脂肪乳与那屈肝素联合治疗复发性流产的效果研究
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摘要
目的分析脂肪乳联合那屈肝素治疗复发性流产(RSA)患者的效果。方法 52例RSA患者随机均分为两组,对照组采用那屈肝素治疗,观察组采用脂肪乳联合那屈肝素治疗,比较两组的凝血功能、妊娠结局以及不良反应。结果孕12周时,观察组的PT水平高于对照组, PLT、 D-D水平低于对照组(P <0.05)。观察组的流产率低于对照组,足月分娩率高于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论脂肪乳联合那屈肝素治疗RSA患者,可有效控制妊娠期凝血功能异常,临床流产率低,不良反应少。
Objective To analyze the effect of fat emulsion combined with nadroparin in the treatment of patients with recurrent spontaneous abortion(RSA). Methods 52 cases of RSA patients were randomly divided into two groups equally. The control group was treated with nadroparin, while the observation group was treated with fat emulsion combined with nadroparin. The coagulation function,pregnancy outcome and adverse reactions were compared between the two groups. Results At 12 weeks of pregnancy, the PT level of observation group was significantly higher than that of control group, and the PLT and D-D levels were significantly lower than those of control group(P <0.05). The abortion rate of the observation group was significantly lower than that of the control group, and full-term delivery rate was significantly higher than that of the control group(P <0.05). No statistical difference was found between the two groups in the incidence of adverse reactions(P >0.05). Conclusions Fat emulsion combined with nadroparin in the treatment of RSA patients can effectively control the abnormal blood coagulation function during pregnancy, with low clinical abortion rate and few adverse reactions.
Objective To analyze the effect of fat emulsion combined with nadroparin in the treatment of patients with recurrent spontaneous abortion(RSA). Methods 52 cases of RSA patients were randomly divided into two groups equally. The control group was treated with nadroparin, while the observation group was treated with fat emulsion combined with nadroparin. The coagulation function,pregnancy outcome and adverse reactions were compared between the two groups. Results At 12 weeks of pregnancy, the PT level of observation group was significantly higher than that of control group, and the PLT and D-D levels were significantly lower than those of control group(P <0.05). The abortion rate of the observation group was significantly lower than that of the control group, and full-term delivery rate was significantly higher than that of the control group(P <0.05). No statistical difference was found between the two groups in the incidence of adverse reactions(P >0.05). Conclusions Fat emulsion combined with nadroparin in the treatment of RSA patients can effectively control the abnormal blood coagulation function during pregnancy, with low clinical abortion rate and few adverse reactions.
引文
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[8]文伟名,黄信琨.酒石酸布托啡诺注射液与依托咪酯脂肪乳注射液用于无痛人工流产的临床观察[J].吉林医学,2012,33(9):1854-1855.
[2]张高,程玲慧.低分子肝素联合小剂量阿司匹林对复发性流产患者激素水平、免疫功能的影响[J].中国生化药物杂志,2015,20(11):67-69.
[3]林炜.早期应用氨基酸联合脂肪乳对早产儿体质量,营养状况及代谢的影响[J].中国计划生育学杂志,2017,25(4):243-246.
[4]潘敦,陈辉,李良庆.添加ω-3鱼油脂肪乳的围术期肠外营养支持对老年胃癌患者营养状况、免疫功能及术后并发症的影响[J].中国老年学杂志,2016,36(19):4792-4794.
[5]肖锋,卢斌,赵伟军,等.鱼油脂肪乳对食管癌病人术后免疫功能的影响[J].肠外与肠内营养,2016,23(1):24-26,33.
[6]顾双双,张均,张均,等.早期那屈肝素预防脑出血患者深静脉血栓形成的安全性[J].国际脑血管病杂志,2014,22(12):902-906.
[7]黄琳,胡素云,黄丽娟,等.脂肪乳替代免疫球蛋白在自然杀伤细胞升高导致复发性流产孕妇中的疗效观察[J].生殖与避孕,2014,34(5):406-409.
[8]文伟名,黄信琨.酒石酸布托啡诺注射液与依托咪酯脂肪乳注射液用于无痛人工流产的临床观察[J].吉林医学,2012,33(9):1854-1855.