葶苈生脉口服液中挥发油的稳定性研究
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摘要
目的验证环糊精包合技术能否有效提高中药制剂中挥发油成分的稳定性。方法提取葶苈生脉组方中白术、桂枝的挥发油,以包合工艺处理所得挥发油制得挥发油包合物,并参与制剂制备葶苈生脉口服液。对所得制剂进行稳定性考察,以桂枝、白术挥发油主要活性成分桂皮醛和白术内酯的含量或最大成分量的变化为指标,衡量制剂中包合后的挥发油与未包合的挥发油的稳定性。结果包合后的挥发油较之未包合的挥发油,其桂皮醛和白术内酯的含量在考察期间比较稳定。结论羟丙基-β-环糊精包合能有效提高葶苈生脉制剂中挥发油成分的稳定性。
Objective To verify whether cyclodextrin inclusion technology can effectively improve the stability of volatile oil components in traditional Chinese medicine preparation. Methods The volatile oil of Rhizoma Atractylodes and Fructus Cinnamomi was extracted from Tinglishengmai recipe. The volatile oil was prepared by the inclusion process and was used to prepare Tinglishengmai oral liquid. The stability of the preparation was investigated. The changes of the contents or the maximum components of cinnamaldehyde and macrocephala lactone in the volatile oil of Guizhi and Atractylodes macrocephala were used as indexes to evaluate the stability of the volatile oil after inclusion and the volatile oil without inclusion. Results The content of cinnamaldehyde in the formulation of the volatile oil after inclusion was relatively stable compared with that of the uncoated volatile oil. Conclusion-Hydroxypropyl-β-cyclodextrin inclusion can effectively improve the stability of volatile oil components in Tingli shengmai preparations.
Objective To verify whether cyclodextrin inclusion technology can effectively improve the stability of volatile oil components in traditional Chinese medicine preparation. Methods The volatile oil of Rhizoma Atractylodes and Fructus Cinnamomi was extracted from Tinglishengmai recipe. The volatile oil was prepared by the inclusion process and was used to prepare Tinglishengmai oral liquid. The stability of the preparation was investigated. The changes of the contents or the maximum components of cinnamaldehyde and macrocephala lactone in the volatile oil of Guizhi and Atractylodes macrocephala were used as indexes to evaluate the stability of the volatile oil after inclusion and the volatile oil without inclusion. Results The content of cinnamaldehyde in the formulation of the volatile oil after inclusion was relatively stable compared with that of the uncoated volatile oil. Conclusion-Hydroxypropyl-β-cyclodextrin inclusion can effectively improve the stability of volatile oil components in Tingli shengmai preparations.
引文
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[2]张静宜,张华潭,魏艳婷,白瑞丹,李春花.多指标综合评价优选葶苈生脉方中桂枝、白术提取工艺[J].中国现代中药,2016,18(08):1034.
[3]王红芳,张静宜,侯芳洁,李春花.葶苈生脉方中挥发油的羟丙基-β-环糊精包合工艺[J].中国老年学杂志,2017,37(06):1327.
[4]史红星,张华潭,张静宜,李春花.多指标综合评价优选葶苈生脉方中丹参、红花提取工艺[J].中国现代中药,2015,17(12):1317.
[5]刘新国,赖炫城,周莉玲.跌打止痛巴布剂中桂皮醛等成分含量的气相色谱法测定[J].时珍国医国药,2010,21(10):2454.
[6]徐艳春,魏璐雪,王亚丽.气相色谱法测定黄连配伍肉桂前后桂皮醛的含量[J].药物分析杂志,2002,22(1):11.
[7]张文光,李叙琳,蔡照南.气相色谱法测定肉桂油中桂皮醛含量[J].中药通报,1988,13(12):38.
[8]陈万宁.气相色谱法测定肉桂油中桂皮醛的含量[J].中国药学杂志,1987,22(10):612.
[9]梁锦杰,吴燕红,张燕梅,罗裕,刘静,朱盛山,黄娟萍,蔡延渠.中药制剂稳定性研究中含量测定的问题分析[J].中国实验方剂学杂志,2014,20(12):253.
[10]李海亮,郝晶晶,龚慕辛.中药挥发油β-环糊精包合物的稳定性影响因素考察[J].中国实验方剂学杂志,2012,18(23):13.
[11]李树珍,官仕杰.八种中药挥发油·β-环糊精包接物的稳定性考察[J].中国中药杂志,1990,15(4):26.