养胃清热化瘀法治疗慢性萎缩性胃炎及癌前病变的临床研究
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摘要
目的:探讨养胃清热化瘀法对慢性萎缩性胃炎伴肠化、异型增生及其转归的影响。方法:将慢性萎缩性胃炎患者60例随机分为2组各30例,治疗组予养胃清热化瘀方加减治疗,对照组予胃复春治疗,治疗2个疗程共6个月。观察2组患者临床疗效以及胃黏膜病理评分变化情况。结果:总有效率治疗组为93.3%,对照组为66.7%,2组比较差异有统计学意义(P<0.05);治疗组治疗后胃黏膜评分优于对照组,2组比较差异有统计学意义(P<0.05)。结论:养胃清热化瘀法能够有效改善慢性萎缩性胃炎及癌前病变患者临床症状,降低胃黏膜病理评分。
Objective: To discuss the effects of the method of stomach-nourishing heat-clearing stasis-removing on the outcome of chronic atrophic gastritis(CAG) accompanying intestinal metaplasia and dysplasia. Methods:Sixty CAG patients were allocated to two groups, 30 cases each group, the treatment group were treated by modified stomach-nourishing heat-clearing stasis-removing prescription, and the control group by WeiFuChun, and they were treated for two courses, six months altogether. Gastric mucosal pathological score, pathological effects and clinical effects of the syndromes of the patients were observed. Results: Total effective rate of the treatment group was93.3%, higher than 66.7% of the control group, and the difference showed statistical meaning(P<0.05); after treating, the treatment group was superior to the control group in gastric mucosal pathological score, and the difference was statistically significant(P<0.05). Conclusion: The method of stomach-nourishing heat-clearing stasis-removing could effectively improve clinical symptoms and decrease gastric mucosal pathological scores of the patients suffering CAG and precancerous lesion.
Objective: To discuss the effects of the method of stomach-nourishing heat-clearing stasis-removing on the outcome of chronic atrophic gastritis(CAG) accompanying intestinal metaplasia and dysplasia. Methods:Sixty CAG patients were allocated to two groups, 30 cases each group, the treatment group were treated by modified stomach-nourishing heat-clearing stasis-removing prescription, and the control group by WeiFuChun, and they were treated for two courses, six months altogether. Gastric mucosal pathological score, pathological effects and clinical effects of the syndromes of the patients were observed. Results: Total effective rate of the treatment group was93.3%, higher than 66.7% of the control group, and the difference showed statistical meaning(P<0.05); after treating, the treatment group was superior to the control group in gastric mucosal pathological score, and the difference was statistically significant(P<0.05). Conclusion: The method of stomach-nourishing heat-clearing stasis-removing could effectively improve clinical symptoms and decrease gastric mucosal pathological scores of the patients suffering CAG and precancerous lesion.
引文
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[20]罗文娟,王光辉,张雪,等.金钗石斛茎提取物联苄类化合物对人肝癌高侵袭转移细胞株FHCC-98增殖的抑制[J].中国临床康复,2006,10(43):150-152.
[2]中国药学会.消化系统疾病治疗药物的合理使用[M].北京:人民卫生出版社,2011:21-25.
[3]陈燕云.中医药治疗慢性萎缩性胃炎的研究进展[J].西部中医药,2013,26(4):123-126.
[4]黄婷婷,周晓虹.中医药治疗慢性萎缩性胃炎癌前病变的研究进展[J].西部中医药,2015,28(8):183-184.
[5]中华中医药学会脾胃病分会.慢性萎缩性胃炎中医诊疗共识意见(2009深圳)[J].中国中西医结合消化杂志,2010,18(5):345-349.
[6]中华医学会消化病学分会.中国慢性胃炎共识意见[J].胃肠病学,2006,11(11):674-684.
[7]Zhang CP,Sun XG,Zhao QX,et al.Efficacy of teprenone in treatment of chronic atrophic gastritis:an analysis of 100 cases[J].World Chinese Journal of Digestology,2008,16(10):1067-1073.
[8]陈忠年.实用外科病理学[M].上海:上海医科大学出版社,1997:337.
[9]Weck MN,Brenner H.Prevalence of chronic atrophic gastritis in different parts of the world[J].Cancer Epidemiol Biomarkers Prev,2006,15(6):1083-1094.
[10]叶天士.临证指南医案[M].北京:华夏出版社,1995:143-144.
[11]郑保平.慢性萎缩性胃炎及其癌前病变的病机和证治探讨[J].江苏中医药,2010,42(1):8-9.
[12]陆为民.仁术健胃颗粒治疗慢性萎缩性胃炎癌前病变的临床与实验研究[D].南京:南京中医药大学,2001:8-19.
[13]殷净先.白术药理研究进展[J].时珍国医国药,2000,11(6):572.
[14]中华人民共和国卫生部药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2010:236.
[15]胡玉兰,张忠义,王文婧,等.砂仁挥发油对大鼠乙酸性胃溃疡的影响及其机理探讨[J].中药材,2005,28(11):1022-1024.
[16]罗彩莲.丹参的药理作用与临床应用[J].中国当代医学,2012,19(12):11-12.
[17]周小玲,李永伟,李逢春,等,三七总皂甙对大鼠免疫功能影响的实验研究[J].广西医科大学学报,2001,18(3):360-361.
[18]陈培丰.清热解毒法诱导肿瘤细胞凋亡的研究[J].浙江中医学院学报,2003,27(1):12-15.
[19]黄民权,蔡体育.铁皮石斛多糖对小白鼠白细胞数和淋巴细胞移动抑制因子的影响[J].天然产物研究与开发,1996,8(3):39-41.
[20]罗文娟,王光辉,张雪,等.金钗石斛茎提取物联苄类化合物对人肝癌高侵袭转移细胞株FHCC-98增殖的抑制[J].中国临床康复,2006,10(43):150-152.