丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效
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摘要
目的探讨丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效。方法按照数字随机分组的形式,将我院收治的90例妊娠期肝内胆汁淤积症患者分为观察组与对照组,每组各45例。对照组患者予以常规熊去氧胆酸联合丁二磺酸腺苷蛋氨酸治疗,观察组患者在此基础上,联合多烯磷脂酰胆碱治疗,观察两组患者的临床疗效及妊娠结局。结果观察组患者治疗后瘙痒症状评分为(1.32±0.17)分,低于对照组患者的(2.46±0.27)分,组间比较,差异具有统计学意义(P <0.05);观察组患者治疗后的肝功能指标TBA、ALT、AST以及TBil水平均优于对照组患者(P <0.05);观察组患者不良妊娠结局发生率明显低于对照组患者,差异具有统计学意义(P <0.05)。结论丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效可靠,对于改善患者临床症状、肝功能及妊娠结局有重要意义。
Objective To investigate the effect of adenosylmethionine butanesulfonate combined with polyene phosphatidylcholine in the treatment of intrahepatic cholestasis of pregnancy. Methods According to the form of digital random grouping, 90 cases of intrahepatic cholestasis of pregnancy in our hospital were divided into observation group and control group, 45 cases in each group. The patients in the control group were treated with ursodeoxycholic acid combined with adenosylmethionine succinate. The patients in the observation group were treated with polyene phosphatidylcholine on this basis. The clinical efficacy and pregnancy outcome of the two groups were observed. Results The score of pruritus symptoms in the observation group was(1.32±0.17) points after treatment,which was lower than that in the control group(2.46±0.27) points. There was a significant difference between the two groups(P < 0.05). The levels of TBA, ALT, AST and TBil in the observation group were better than those in the control group(P < 0.05). The incidence of adverse pregnancy outcomes in the observation group was significantly lower than that in the control group(P < 0.05). Conclusion Adenomethionine butanesulfonate combined with polyene phosphatidylcholine is effective in the treatment of intrahepatic cholestasis of pregnancy. It is important to improve the clinical symptoms, liver function and pregnancy outcomes of patients.
Objective To investigate the effect of adenosylmethionine butanesulfonate combined with polyene phosphatidylcholine in the treatment of intrahepatic cholestasis of pregnancy. Methods According to the form of digital random grouping, 90 cases of intrahepatic cholestasis of pregnancy in our hospital were divided into observation group and control group, 45 cases in each group. The patients in the control group were treated with ursodeoxycholic acid combined with adenosylmethionine succinate. The patients in the observation group were treated with polyene phosphatidylcholine on this basis. The clinical efficacy and pregnancy outcome of the two groups were observed. Results The score of pruritus symptoms in the observation group was(1.32±0.17) points after treatment,which was lower than that in the control group(2.46±0.27) points. There was a significant difference between the two groups(P < 0.05). The levels of TBA, ALT, AST and TBil in the observation group were better than those in the control group(P < 0.05). The incidence of adverse pregnancy outcomes in the observation group was significantly lower than that in the control group(P < 0.05). Conclusion Adenomethionine butanesulfonate combined with polyene phosphatidylcholine is effective in the treatment of intrahepatic cholestasis of pregnancy. It is important to improve the clinical symptoms, liver function and pregnancy outcomes of patients.
引文
[1]何早琴,袁艺.妊娠期肝内胆汁淤积症的临床特征[J].临床医学研究与实践,2018,3(25):134-135.
[2]李涛.妊娠期肝内胆汁淤积症孕妇的胎儿不良结局的危险因素分析[J].中国妇幼健康研究,2017,28(2):128-130.
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[4]张公镇,王倩.多烯磷脂酰胆碱联合腺苷蛋氨酸对妊娠期肝内胆汁淤积症患者妊娠结局的影响[J].淮海医药,2018,36(4):382-384.
[5]曹杰,蔡艾杞,田立碧,等.熊去氧胆酸、腺苷蛋氨酸联合多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症患者相关指标的影响[J].中国药房,2017,28(18):2509-2511.
[6]周荣琴.多烯磷脂酰胆碱对妊娠期胆汁淤积症患者症状、肝功能及妊娠结局的影响[J].中国医学工程,2018,26(3):19-22.
[7]吴珊.多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效及对妊娠结局的影响[J].现代诊断与治疗,2017,28(22):4170-4172.
[8]杨德红,邵庆华.丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效观察[J].肝脏,2018,23(4):357-359.
[9]蔡婷婷,王薇,谢雪玲,等.熊去氧胆酸联合腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症临床分析[J].实用肝脏病杂志,2016,19(5):610-611.
[10]王淑平,陈宝艳,刘志辉,等.中西医联合治疗妊娠期肝内胆汁淤积症的临床疗效及其对Th17/Treg平衡的影响[J].新医学,2015,46(5):308-311.
[11]臧秋霞.多烯磷脂酰胆碱辅助治疗妊娠期肝内胆汁淤积症效果观察[J].中国处方药,2016,14(10):47-48.
[12]刘益华,王菲.多烯磷脂酰胆碱联合丁二磺酸腺苷蛋氨酸对妊娠期肝内胆汁淤积症患者胆汁酸、肝酶指标及妊娠期结局的影响[J].齐齐哈尔医学院学报,2018,39(8):890-892.
[2]李涛.妊娠期肝内胆汁淤积症孕妇的胎儿不良结局的危险因素分析[J].中国妇幼健康研究,2017,28(2):128-130.
[3]周丽.妊娠期肝内胆汁淤积症临床特点与妊娠结局分析[J].中国社区医师,2018,34(14):79-81.
[4]张公镇,王倩.多烯磷脂酰胆碱联合腺苷蛋氨酸对妊娠期肝内胆汁淤积症患者妊娠结局的影响[J].淮海医药,2018,36(4):382-384.
[5]曹杰,蔡艾杞,田立碧,等.熊去氧胆酸、腺苷蛋氨酸联合多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症患者相关指标的影响[J].中国药房,2017,28(18):2509-2511.
[6]周荣琴.多烯磷脂酰胆碱对妊娠期胆汁淤积症患者症状、肝功能及妊娠结局的影响[J].中国医学工程,2018,26(3):19-22.
[7]吴珊.多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效及对妊娠结局的影响[J].现代诊断与治疗,2017,28(22):4170-4172.
[8]杨德红,邵庆华.丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效观察[J].肝脏,2018,23(4):357-359.
[9]蔡婷婷,王薇,谢雪玲,等.熊去氧胆酸联合腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症临床分析[J].实用肝脏病杂志,2016,19(5):610-611.
[10]王淑平,陈宝艳,刘志辉,等.中西医联合治疗妊娠期肝内胆汁淤积症的临床疗效及其对Th17/Treg平衡的影响[J].新医学,2015,46(5):308-311.
[11]臧秋霞.多烯磷脂酰胆碱辅助治疗妊娠期肝内胆汁淤积症效果观察[J].中国处方药,2016,14(10):47-48.
[12]刘益华,王菲.多烯磷脂酰胆碱联合丁二磺酸腺苷蛋氨酸对妊娠期肝内胆汁淤积症患者胆汁酸、肝酶指标及妊娠期结局的影响[J].齐齐哈尔医学院学报,2018,39(8):890-892.