中药方剂联合核黄素防治鼻咽癌放射性口腔黏膜反应的效果观察
摘要
[目的]研究中药方剂联合核黄素防治鼻咽癌放射性口腔黏膜反应的疗效。[方法]选取医院就诊的80例鼻咽癌病人,根据随机数字表法分为观察组和对照组,两组病人均行常规放疗,对照组病人给予复方氯己定漱口液联合核黄素治疗,观察组在对照组基础上给予中药方剂治疗,观察两组病人放疗中及放疗后放射性口腔黏膜炎发生情况、疼痛数字分级法(NRS)评分、唾液表皮生长因子(EGF)水平以及鼻咽癌病人生存质量简短版量表(QOL-NPC13)评分、不良反应发生情况。[结果]放疗3周、6周及放疗结束时观察组Ⅱ级及以上放射性口腔黏膜炎发生率显著低于对照组(P<0.05);放疗后5 d、10 d及15 d观察组Ⅱ级及以上放射性口腔黏膜炎发生率显著低于对照组(P<0.05);放疗3周、6周以及放疗结束时观察组NRS评分均显著低于对照组(P<0.05);放疗后两组病人唾液表皮生长因子(EGF)水平以及QOL-NPC13评分均显著降低,且观察组唾液EGF水平以及QOL-NPC13评分显著高于对照组(P<0.05);两组病人不良反应发生率比较差异无统计学意义(P>0.05)。[结论]中药方剂联合核黄素能显著减轻鼻咽癌病人放射性口腔黏膜反应程度,加快放疗后口腔黏膜恢复,减轻病人疼痛,提高病人生活质量。
引文
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[2] 连利霞,孔存权,雒建超,等.核黄素磷酸钠联合复方苦参注射液治疗鼻咽癌放射性口腔黏膜炎临床疗效观察[J].现代肿瘤医学,2017,25(24):3957-3961.
[3] 陈新林,程皖琴,王蕾,等.鼻咽癌患者生存质量简短版量表的研制和评价[J].中华肿瘤防治杂志,2016,23(2):79-83.
[4] 王莉,杨艳.思密达药冰防治鼻咽癌放射性口腔黏膜炎的效果[J].当代护士,2016(9):134-136.
[5] 梁少琴,邹颖,王燕燕.中药治疗鼻咽癌急性放射性口腔炎与口腔干燥30例临床研究[J].内蒙古中医药,2014,33(15):3-4.
[6] XUAN Z,AN Y,YANG D,et al.Exploration of the protection of riboflavin laurate on oral mucositis induced by chemotherapy or radiotherapy at the cellular level:what is the leading contributor?[J].Int J Mol Sci,2013,14(3):4722-4733.
[7] YU G,SUN J,JIANG Q,et al.Clinical observation of parenteral nutrition support in patients undergoing hematopoietic stem cell transplantation[J].Chinese Journal of Clinical Nutrition,2014,22(2):87-91.
[8] LIAN L,KONG C,LUO J,et al.Efficacy of riboflavin sodium phosphate combined with compound Kushen injection of radtioactive oral mucosal injury on nasopharyngeal carcinoma[J].Journal of Modern Oncology,2017,25(24):3957-3960.
[9] 林兰珍,徐燕,刘艳华,等.鼻咽癌放疗患者采用中药液含漱减轻口腔黏膜反应的效果观察[J].中华现代护理杂志,2014,20(11):1285-1287.
[10] 汪春艳.自拟中药方联合西药治疗鼻咽癌患者急性放射性口腔炎的临床观察[J].中国中医急症,2016,25(8):1617-1619.
[11] RUSSO N,BELLILE E,MURDOCH-KINCH C A,et al.Cytokines in saliva increase in head and neck cancer patients after treatment[J].Oral Surgery Oral Medicine Oral Pathology & Oral Radiology,2016,122(4):483-490.
[12] ECKLEY C A,SARDINHA L R,RIZZO L V.Salivary concentration of epidermal growth factor in adults with reflux laryngitis before and after treatment[J].Annals of Otology Rhinology & Laryngology,2013,122(7):440-443.
[13] AZUMA N,KATADA Y,KITANO S,et al.Salivary epidermal growth factor (EGF) in Sj?gren′s syndrome:association between salivary EGF levels and the severity of intraoral manifestations[J].Nihon Rinshσ Men′eki Gakkai kaishi Japanese Journal of Clinical Immunology,2014,39(1):42-42.
[14] AZUMA N,KATADA Y,SANO H.Deterioration in saliva quality in patients with Sj?gren′s syndrome:impact of decrease in salivary epidermal growth factor on the severity of intraoral manifestations[J].Inflammation & Regeneration,2018,38(1):6.