碱性成纤维细胞生长因子对腹部创面愈合影响的临床研究
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摘要
探讨碱性成纤维细胞生长因子对腹部创面愈合情况的影响。选择2017年8月—2018年12月本院收治的腹部创面患者90例,采用随机数字表法分为研究组和对照组,各45例。对照组患者予以常规治疗;研究组患者在此基础上联合碱性成纤维细胞生长因子涂抹治疗,比较两组疗效。研究组治疗7 d后的肉芽生长评分、水肿评分、渗液评分明显低于对照组,差异具有统计学意义(P<0.05)。研究组治疗后血管分布评分、柔软度评分、色泽评分、厚度评分明显低于对照组,差异具有统计学意义(P<0.05)。研究组患者治疗后IL-1β、IL-6、TNF-α水平明显低于对照组,IL-10、IL-4水平明显高于对照组,差异均具有统计学意义(P<0.05)。局部涂抹碱性成纤维细胞生长因子能够减少腹部创面水肿及渗液,减轻血肿形成,降低感染几率,减轻瘢痕,促进愈合。
引文
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[2]王世霞,陈永乐,王亚儒,等.湿润生肌膏对肛瘘术后创面肉芽组织中碱性成纤维细胞生长因子mRNA表达的影响[J].检验医学与临床,2018,15(05):657-659,663.
[3]马启海.血必净注射液联合重组牛碱性成纤维细胞生长因子凝胶治疗深度烧伤残余创面的临床研究[J].现代药物与临床,2017,32(12):2469-2472.
[4]Parazzini F,dicintio E,chatenoud L,et al.estroprogestin vs.gonadotropin agonistsplus estroprogestin in the treatment of endometriosis-related pelvic pain:a randomized trial[J].Eurjobstet Gynecol Reprod Biol,2016,88(1):11.
[5]Dmowski wp,Pry M,ding j,et al.cycle-specific and cumulative fecundity in pstients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or vitrofertilization-embryotransfer[J].Eertil Steril,2017,78(4):750-756.
[6]Nezhat C,Siegler A,Nezhat f,et al.Operative gynecologic laparoscopy:principles and techniques.2nd ed[J].New York:Mcgraw-hillpublishing house,2016,7(3):52-53.
[7]林旋霞,张鸿生,黄汉伟,等.外用碱性成纤维细胞生长因子联合超短波治疗糖尿病足溃疡临床观察[J].海南医学,2017,28(05):734-736.
[8]李建武,薛宏斌,高栋梁,等.多种细胞生长因子联合应用对烧伤创面愈合的影响[J].中国现代医药杂志,2016,18(01):17-20.
[9]Yang Y,Zhang X,Zhou.elevated Immunoreactivity of rantes and ccr1 correlate with the severity of stages and dysmenorrhea in women with deep infiltrating endometriosis[J].Acta Histochemica:Aeitschrift Furhistologische Topochemie,2013,115(5):247-248.
[10]Govatati S,Kodati VL,Deenadayal M.Mutations in the PTENtumorgene and risk of endometriosis:a case-control study[J].Hum Reprod,2014,29(2):378-379.
[11]何凤金.外用重组人碱性成纤维细胞生长因子治疗外伤缺损性创面的疗效观察[J].中国现代药物应用,2015,9(09):30-31.
[12]刘小飞.碱性成纤维细胞生长因子对皮肤软组织撕脱伤创面修复效果及肝肾功能影响[J].海南医学院学报,2015,21(01):80-82.