基于COMSOL和NEURON的坐骨神经电刺激模型
|
摘要
为研究周围神经在接受电刺激时的兴奋规律,建立了坐骨神经电刺激的仿真模型。利用有限元仿真软件COMSOL对神经和卡肤电极建模并计算神经周围在外加刺激下的电场分布情况,将此电场分布信息导入到神经建模软件NEURON建立的神经模型中作为细胞外激励源,以分析电刺激下神经的电生理行为。在此模型上分析了刺激电极尺寸和间距、电刺激波形、环境温度和局部温度等参数对坐骨神经纤维兴奋性的影响,为神经功能电刺激的进一步研究及临床应用提供了理论基础。
We established a sciatic nerve electrical simulation model for studying the excitability of peripheral nerve treated with electrical stimulation.The electric field distribution of peripheral nerve and cuff electrode model established with finite element simulation software COMSOL was calculated in external stimuli,and taken as the extracellular excitation source in neural model established based on neural modeling software NEURON to analyze the electrophysiological behavior of nerve.Based on the established model,we analyze the effect of the size and gap of the stimulation electrodes,the electrical stimulation waveform,the global temperature and the local temperature of some nodes on the excitability of the sciatic nerve fiber,providing a theoretical basis and technical guidance for the further research and clinical trials of electrical nerve stimulation.
We established a sciatic nerve electrical simulation model for studying the excitability of peripheral nerve treated with electrical stimulation.The electric field distribution of peripheral nerve and cuff electrode model established with finite element simulation software COMSOL was calculated in external stimuli,and taken as the extracellular excitation source in neural model established based on neural modeling software NEURON to analyze the electrophysiological behavior of nerve.Based on the established model,we analyze the effect of the size and gap of the stimulation electrodes,the electrical stimulation waveform,the global temperature and the local temperature of some nodes on the excitability of the sciatic nerve fiber,providing a theoretical basis and technical guidance for the further research and clinical trials of electrical nerve stimulation.
引文
[1]沈强,刘雪良,蒋大宗,等.利用双向方波脉冲刺激实现神经纤维选择性兴奋的双电极方法[J].中国生物医学工程学报,2001,20(6):533-540.SHEN Q,LIU X L,JIANG D Z,et al.A bipolar method for selective activation of nerve fibers using biphasic rectangular pulses[J].Chinese Journal of Biomedical Engineering,2001,20(6):533-540.
[2]GRILL W,NORMAN S,BELLAMKONDA R.Implanted neural interfaces:biochallenges and engineered solutions[J].Biomed Eng,2009,11(1):1.
[3]VERAART C,GRILL W,MORTIMER J.Selective control of muscle activation with a multipolar nerve cuff electrode[J].IEEE Trans Biomed Eng,1993,40(7):640-653.
[4]ZARIFFA J,NAGAI M,DASKALAKIS Z,et al.Influence of the number and location of recording contacts on the selectivity of a nerve cuff electrode[J].IEEE Trans Neural Syst Rehabil Eng,2009,17(5):420-427.
[5]BARATTA R,ICHIE M,HWANG S K,et al.Ordery stimulation of skeletal muscle motor units with tripolar nerve cuff electrode[J].IEEE Trans Biomed Eng,1989,36(8):836-843.
[6]FANG Z P,MORTIMER J T.Selective activations of small motor axons by quasitrapezoidal current pulses[J].IEEE Trans Biomed Eng,1991,38(2):168-174.
[7]MOU Z,TRIANTIS I F,WOODS V M,et al.A simulation study of the combined thermoelectric ectracellular stimulation of the sciatic nerve of the xenopus laevis:the heat block[J].IEEE Trans Biomed Eng,2012,59(6):1758-1769.
[8]RUNGE-SAMUELSONC L.Effects of high-rate pulse trains on electrodeiscrimination in cochlear implant users[J].Trends Amplif,2009,13(2):76-86.
[9]CARNEVALE N T,HINES M L.The NEURON book[M].Cambridge University Press,2006.
[10]FRANKENHAEUSER B,HUXLEY A F.The action potential in the myelinated nerve fibre of Xenopus laevis as computed on the basis of voltage clamp data[J].J Physiol,1964,171(2):302-315.
[11]牟宗霞.用于神经功能修复的电、近红外激光及其组合刺激方法的研究[D].重庆:重庆大学,2012.MOU Z X.Research on functional electrical stimulation,near-infrared neural stimulation,and their combination in neural prosthesis[D].Chongqing:Chongqing University,2012.
[12]HUTCHINSON N A,KOLES Z J,SMITH R S.Conduction velocity in myelinated nerve fibres of Xenopus laevis[J].J Physiol,1970,208(2):279-289.
[13]WANG Y,GUO L.Nanomaterial-enabled neural stimulation[J].Front Neurosci,2016,10(7):69.
[14]YOO S,HONG S,CHOI Y,et al.Photothermal inhibition of neural activity with near-infrared-sensitive nanotransducers[J].ACS Nano,2014,8(8):8040-8049.
[15]NICOLA M,PAUL F,MATTEO P,et al.Photothermal cellular stimulation in functional bio-polymer interfaces[J].Sci Rep,2015,5:8911.
[16]沈强,邰常峰,蒋大宗.神经纤维双向选择性刺激方法仿真研究[J].生物医学工程学杂志,1998,15(1):17-21.SHEN Q,TAI C F,JIANG D Z.Simulation study of selectively stimulating nerve fibers using biphasic pulses[J].Journal of Biomedical Engineering,1998,15(1):17-21.
[17]黄愉.视网膜上电刺激的三维有限元建模和仿真研究[D].上海:上海交通大学,2012.HUANG Y.3-D finite element analyses of the epi-retinal electrical stimulation[D].Shanghai:Shanghai Jiao Tong University,2012.
[18]BUTSON C R,MILLER I O,NORMANN R A,et al.Selective neural activation in a histologically derived model of peripheral nerve[J].J Neural Eng,2011,8(3):036009.
[19]GOODALL E V,KOSTERMAN L M,HOLSHEIMER J,et al.Modeling study of activation and propagation delays during stimulation of peripheral nerve fibers with a tripolar cuff electrode[J].IEEE Trans Rehabil Eng,1995,3(3):272-282.
[20]RATTAY F,ABERHAM M.Modeling axon membranes for functional electrical stimulation[J].IEEE Trans Biomed Eng,1993,40(12):1201-1209.
[2]GRILL W,NORMAN S,BELLAMKONDA R.Implanted neural interfaces:biochallenges and engineered solutions[J].Biomed Eng,2009,11(1):1.
[3]VERAART C,GRILL W,MORTIMER J.Selective control of muscle activation with a multipolar nerve cuff electrode[J].IEEE Trans Biomed Eng,1993,40(7):640-653.
[4]ZARIFFA J,NAGAI M,DASKALAKIS Z,et al.Influence of the number and location of recording contacts on the selectivity of a nerve cuff electrode[J].IEEE Trans Neural Syst Rehabil Eng,2009,17(5):420-427.
[5]BARATTA R,ICHIE M,HWANG S K,et al.Ordery stimulation of skeletal muscle motor units with tripolar nerve cuff electrode[J].IEEE Trans Biomed Eng,1989,36(8):836-843.
[6]FANG Z P,MORTIMER J T.Selective activations of small motor axons by quasitrapezoidal current pulses[J].IEEE Trans Biomed Eng,1991,38(2):168-174.
[7]MOU Z,TRIANTIS I F,WOODS V M,et al.A simulation study of the combined thermoelectric ectracellular stimulation of the sciatic nerve of the xenopus laevis:the heat block[J].IEEE Trans Biomed Eng,2012,59(6):1758-1769.
[8]RUNGE-SAMUELSONC L.Effects of high-rate pulse trains on electrodeiscrimination in cochlear implant users[J].Trends Amplif,2009,13(2):76-86.
[9]CARNEVALE N T,HINES M L.The NEURON book[M].Cambridge University Press,2006.
[10]FRANKENHAEUSER B,HUXLEY A F.The action potential in the myelinated nerve fibre of Xenopus laevis as computed on the basis of voltage clamp data[J].J Physiol,1964,171(2):302-315.
[11]牟宗霞.用于神经功能修复的电、近红外激光及其组合刺激方法的研究[D].重庆:重庆大学,2012.MOU Z X.Research on functional electrical stimulation,near-infrared neural stimulation,and their combination in neural prosthesis[D].Chongqing:Chongqing University,2012.
[12]HUTCHINSON N A,KOLES Z J,SMITH R S.Conduction velocity in myelinated nerve fibres of Xenopus laevis[J].J Physiol,1970,208(2):279-289.
[13]WANG Y,GUO L.Nanomaterial-enabled neural stimulation[J].Front Neurosci,2016,10(7):69.
[14]YOO S,HONG S,CHOI Y,et al.Photothermal inhibition of neural activity with near-infrared-sensitive nanotransducers[J].ACS Nano,2014,8(8):8040-8049.
[15]NICOLA M,PAUL F,MATTEO P,et al.Photothermal cellular stimulation in functional bio-polymer interfaces[J].Sci Rep,2015,5:8911.
[16]沈强,邰常峰,蒋大宗.神经纤维双向选择性刺激方法仿真研究[J].生物医学工程学杂志,1998,15(1):17-21.SHEN Q,TAI C F,JIANG D Z.Simulation study of selectively stimulating nerve fibers using biphasic pulses[J].Journal of Biomedical Engineering,1998,15(1):17-21.
[17]黄愉.视网膜上电刺激的三维有限元建模和仿真研究[D].上海:上海交通大学,2012.HUANG Y.3-D finite element analyses of the epi-retinal electrical stimulation[D].Shanghai:Shanghai Jiao Tong University,2012.
[18]BUTSON C R,MILLER I O,NORMANN R A,et al.Selective neural activation in a histologically derived model of peripheral nerve[J].J Neural Eng,2011,8(3):036009.
[19]GOODALL E V,KOSTERMAN L M,HOLSHEIMER J,et al.Modeling study of activation and propagation delays during stimulation of peripheral nerve fibers with a tripolar cuff electrode[J].IEEE Trans Rehabil Eng,1995,3(3):272-282.
[20]RATTAY F,ABERHAM M.Modeling axon membranes for functional electrical stimulation[J].IEEE Trans Biomed Eng,1993,40(12):1201-1209.