杀胚消癥煎剂治疗未破裂型异位妊娠
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摘要
目的:观察杀胚消癥煎剂对未破裂型异位妊娠患者恢复的影响。方法:88例未破裂型输卵管异位妊娠患者根据随机数字表法平均分为对照组和观察组。对照组给予氨蝶呤+米非司酮,观察组在对照组治疗基础上给予杀胚消癥煎剂。治疗后,比较两组患者血清β-人绒毛膜促性腺激素(human chorionic gonadotropin,β-HCG)水平恢复时间、异位妊娠包块吸收时间、临床疗效、输卵管通畅情况、月经恢复时间、住院时间以及不良反应发生情况。结果:观察组和对照组异位妊娠包块吸收时间分别为(13.06±5.21)d、(16.93±8.06)d,血β-HCG水平恢复时间分别为(84.36±15.75)d、(97.24±17.42)d,差异均有统计学意义(P<0.05)。观察组治愈率为95.45%(42/44),对照组为79.55%(35/44),两组治愈率比较,差异有统计学意义(P<0.05)。观察组输卵管通畅率为90.91%(40/44),明显高于对照组的72.73%(32/44),差异有统计学意义(P<0.05)。对照组和观察组患者月经恢复时间分别为(36.18±8.52)d、(24.61±7.69)d,住院时间分别为(34.12±12.03)d、(25.02±0.85)d,差异均有统计学意义(P<0.05)。观察组不良反应发生率为11.36%(5/44),对照组为29.55%(13/44),两组比较,差异有统计学意义(P<0.05)。结论:杀胚消癥煎剂治疗未破裂型异位妊娠患者行能有效缩短异位妊娠包块吸收时间和血β-HCG水平恢复时间,提高临床治愈率和输卵管通畅率,缩短月经恢复时间及住院时间,且能有效降低不良反应发生率。
Objective:To investigate the clinical effect of Shapei Xiaozheng Decoction in treatment of unruptured tubal ectopic pregnancy(URTEP).Methods:88 URTEP patients from January 2016 to March 2017 were selected,and they were divided into two groups by using random number table.44 cases of the control group were given methotrexate and mifepristone,while 44 cases of the research group were treated with Shapei Xiaozheng Decoction.The β-human chorionic gonadotropin(HCG) returned to normal time,absorption time of ectopic pregnancy masses,clinical efficacy,tubal patency,adverse reactions of the two groups were compared.Results:The absorption time of ectopic pregnancy masses in research group and control group were(13.06±5.21) d and(16.93±8.06) d,the β-HCG returned to normal time in research group and control group were(84.36±15.75) d and(97.24±17.42) d(P<0.05).The cure rate of research group was 95.45%(42/44),which was significantly higher than that(79.55%,35/44) of the control group(P<0.05).The tubal patency rate of research group was 90.91%(40/44),which was significantly higher than that(72.73%,32/44) of the control group(P<0.05).The total incidence of adverse reactions in research group was 11.36%(5/44),which was significantly lower than that(29.55%,13/44) of the control group(P<0.05).Conclusion:Shapei Xiaozheng Decoction in treatment of URTEP can effectively shorten the absorption time of ectopic pregnancy masses and β-HCG returning to normal time,increase the cure rate and tubal patency rate,decrease the incidence of adverse reactions,with higher safety.
Objective:To investigate the clinical effect of Shapei Xiaozheng Decoction in treatment of unruptured tubal ectopic pregnancy(URTEP).Methods:88 URTEP patients from January 2016 to March 2017 were selected,and they were divided into two groups by using random number table.44 cases of the control group were given methotrexate and mifepristone,while 44 cases of the research group were treated with Shapei Xiaozheng Decoction.The β-human chorionic gonadotropin(HCG) returned to normal time,absorption time of ectopic pregnancy masses,clinical efficacy,tubal patency,adverse reactions of the two groups were compared.Results:The absorption time of ectopic pregnancy masses in research group and control group were(13.06±5.21) d and(16.93±8.06) d,the β-HCG returned to normal time in research group and control group were(84.36±15.75) d and(97.24±17.42) d(P<0.05).The cure rate of research group was 95.45%(42/44),which was significantly higher than that(79.55%,35/44) of the control group(P<0.05).The tubal patency rate of research group was 90.91%(40/44),which was significantly higher than that(72.73%,32/44) of the control group(P<0.05).The total incidence of adverse reactions in research group was 11.36%(5/44),which was significantly lower than that(29.55%,13/44) of the control group(P<0.05).Conclusion:Shapei Xiaozheng Decoction in treatment of URTEP can effectively shorten the absorption time of ectopic pregnancy masses and β-HCG returning to normal time,increase the cure rate and tubal patency rate,decrease the incidence of adverse reactions,with higher safety.
引文
[1]李翠梅,翟晓枝,刘佩秀.未破裂型输卵管妊娠阴道超声引导下介入保守治疗效果观察[J].中国药物与临床,2016,16(4):520-521.
[2]桑鹏,李放.超声引导局部注射MTX对未破裂型宫外孕的治疗价值[J].医学影像学杂志,2016,26(11):2061-2064.
[3]李香红,肖海燕.两种治疗方案用于未破裂型输卵管妊娠的临床效果比较[J].中国基层医药,2015,22(22):3460-3463.
[4]李晓辉.甲氨蝶呤联合米非司酮治疗未破裂异位妊娠患者的疗效及不良反应[J].中国药物与临床,2016,16(3):406-407.
[5]李海侠,田轶,广会娟.超声引导下甲氨蝶呤局部注射联合米非司酮治疗未破裂型输卵管妊娠[J].中国微创外科杂志,2015,15(10):907-909.
[6]李晓荣,黄艳茜,邓高丕.化瘀消癥杀胚中药复方诱导人输卵管妊娠滋养细胞凋亡[J].中成药,2014,36(9):1813-1817.
[7]乐杰.妇产科学[M].6版.北京:人民卫生出版社,2012:139-140.
[8]罗颂平.中医妇科学[M].北京:中国中医药出版社,2007:202-207.
[9]孙传兴.临床疾病诊断依据治愈好转标准[S].北京:人民军医出版社,2002:51.
[10]罗丽兰.不孕与不育[M].北京:人民卫生出版社,1998:190.
[11]解莹,范桂金.甲氨蝶呤配合活血化瘀中药治疗稳定型异位妊娠的效果[J].实用临床医药杂志,2016,20(24):106.
[12]宗秀芬,郭艳蒲.不同保守治疗方法对未破裂型异位妊娠患者的疗效及不良反应[J].中国医药导报,2015,12(9):102-105.
[13]郜洁,胡昀昀,黄艳茜,等.中西医结合药物治疗输卵管妊娠疗效的影响因素分析[J].中医杂志,2016,57(16):1388-1392.
[14]刘瑞华,吴丽敏,乔宗惠,等.活血化瘀法预处理对输卵管性不孕体外受精-胚胎移植(IVF-ET)妊娠结局的影响[J].云南中医学院学报,2016,39(5):62-64.
[15]刘淑文,王珊珊.椒辛散治疗输卵管通而不畅不孕症临床观察[J].现代中西医结合杂志,2016,25(26):2934-2936.
[16]李玉萍,王飞,薛彩星,等.化瘀散结灌肠液配合低频脉冲电对宫外孕包块及输卵管通畅性的影响[J].长春中医药大学学报,2016,32(6):1230-1232.
[17]卢晔.化瘀通络方改善输卵管妊娠药物保守治疗后生育能力的效果研究[J].中国妇幼保健,2015,30(35):6374-6375.
[18]赵新春.中西医结合治疗输卵管堵塞性不孕症[J].吉林中医药,2015,35(11):1132-1135.
[19]郑凤平,杨国文,孙冬梅,等.温经通络散联合盆炎清栓治疗输卵管阻塞性不孕症43例[J].中国药业,2014,23(2):87-89.
[20]王玉,刘丽娜.输卵管再通术联合中药治疗输卵管阻塞性不孕症的疗效分析[J].中国性科学,2014,23(7):82-84.
[2]桑鹏,李放.超声引导局部注射MTX对未破裂型宫外孕的治疗价值[J].医学影像学杂志,2016,26(11):2061-2064.
[3]李香红,肖海燕.两种治疗方案用于未破裂型输卵管妊娠的临床效果比较[J].中国基层医药,2015,22(22):3460-3463.
[4]李晓辉.甲氨蝶呤联合米非司酮治疗未破裂异位妊娠患者的疗效及不良反应[J].中国药物与临床,2016,16(3):406-407.
[5]李海侠,田轶,广会娟.超声引导下甲氨蝶呤局部注射联合米非司酮治疗未破裂型输卵管妊娠[J].中国微创外科杂志,2015,15(10):907-909.
[6]李晓荣,黄艳茜,邓高丕.化瘀消癥杀胚中药复方诱导人输卵管妊娠滋养细胞凋亡[J].中成药,2014,36(9):1813-1817.
[7]乐杰.妇产科学[M].6版.北京:人民卫生出版社,2012:139-140.
[8]罗颂平.中医妇科学[M].北京:中国中医药出版社,2007:202-207.
[9]孙传兴.临床疾病诊断依据治愈好转标准[S].北京:人民军医出版社,2002:51.
[10]罗丽兰.不孕与不育[M].北京:人民卫生出版社,1998:190.
[11]解莹,范桂金.甲氨蝶呤配合活血化瘀中药治疗稳定型异位妊娠的效果[J].实用临床医药杂志,2016,20(24):106.
[12]宗秀芬,郭艳蒲.不同保守治疗方法对未破裂型异位妊娠患者的疗效及不良反应[J].中国医药导报,2015,12(9):102-105.
[13]郜洁,胡昀昀,黄艳茜,等.中西医结合药物治疗输卵管妊娠疗效的影响因素分析[J].中医杂志,2016,57(16):1388-1392.
[14]刘瑞华,吴丽敏,乔宗惠,等.活血化瘀法预处理对输卵管性不孕体外受精-胚胎移植(IVF-ET)妊娠结局的影响[J].云南中医学院学报,2016,39(5):62-64.
[15]刘淑文,王珊珊.椒辛散治疗输卵管通而不畅不孕症临床观察[J].现代中西医结合杂志,2016,25(26):2934-2936.
[16]李玉萍,王飞,薛彩星,等.化瘀散结灌肠液配合低频脉冲电对宫外孕包块及输卵管通畅性的影响[J].长春中医药大学学报,2016,32(6):1230-1232.
[17]卢晔.化瘀通络方改善输卵管妊娠药物保守治疗后生育能力的效果研究[J].中国妇幼保健,2015,30(35):6374-6375.
[18]赵新春.中西医结合治疗输卵管堵塞性不孕症[J].吉林中医药,2015,35(11):1132-1135.
[19]郑凤平,杨国文,孙冬梅,等.温经通络散联合盆炎清栓治疗输卵管阻塞性不孕症43例[J].中国药业,2014,23(2):87-89.
[20]王玉,刘丽娜.输卵管再通术联合中药治疗输卵管阻塞性不孕症的疗效分析[J].中国性科学,2014,23(7):82-84.