亚急性1,2二氯乙烷中毒性脑病1例报告及文献复习
摘要
<正>1,2二氯乙烷(DCE)常被用于工业有机溶剂,长时期接触可造成职业暴露,导致亚急性中毒性脑病。同时,中毒性脑病是接触DCE最常见且最严重的疾病[1,2]。1,2二氯乙烷中毒性脑病是一种较为少见的累及脑白质中毒性病变,该病具有DCE接触史、发病突然、病情进展快且可以急性加重等特点。现将近期我院收治的1例亚急性1,2二氯乙烷中毒性脑病诊疗情况进行分析且报道。1临床资料患者,女性,30岁,农民,初中文化,主因头痛、记忆力减退10 d于2018年7月11日入院。10 d前(2018年7月1日)无明显诱因出现头痛,以双侧额颞叶为主,呈持续性胀
引文
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[11]张卫清,孟学莲.1,2-二氯乙烷中毒性脑病的临床及影像学特点分析[J].空军医学杂志,2016,32(6):389-391.
[12]Zhan F,Zheng W,Liu L,et al.Diagnosis and prognosis evaluation of1,2-dichloroethane encephalopathy-magnetic resonance imaging combined with diffusion tensor imaging and magnetic resonance spectroscopy study[J].Neurol India,2011,59(1):108-110.
[13]Xiaoliang Zhou,Wenbin Zhou,Jinxia Zhou,et al.1,2-Dichloroethane-induced toxic leukoencephalopathy with a brain biopsy[J].Neurol Sci,2015,36:817-819.
[14]王秋莎.高压氧综合治疗二氯乙烷中毒性脑病3例[J].中华航海医学与高气压医学杂志,2005,12(3):192.
[2]Liu JR,Fang S,Ding MP,et al.Toxic encephalopathy caused by occupational exposure to 1,2-Dichloroethane[J].J Neurol Sci,2010,292(1-2):111-113.
[3]林海勇,杨志辉.1,2-二氯乙烷中毒性脑病的CT和MRI表现[J].实用放射学杂志,2009,25(5):628-636.
[4]张勤丽,王林平,郭小丽,等.1,2-二氯乙烷对血脑屏障的损伤作用[J].中华劳动卫生职业病杂志,2006,24(4):239-242.
[5]郭晓丽,牛侨.兴奋性氨基酸与1,2-二氯乙烷急性中毒性脑病关系的探讨[J].中华劳动卫生职业病杂志,2003,21(2):83-85.
[6]牛侨,郭晓丽.N-甲基-D-天冬氨酸Ⅰ型受体在1,2-二氯乙烷急性中毒性脑病中的表达[J].中华劳动卫生职业病杂志,2007,25(2):65-68.
[7]王静,曹长春.钙离子在1,2-二氯乙烷致急性中毒性脑病中的作用[J].职业与健康,2017,33(1):38-40.
[8]黄建勋,牛侨,梁友信,等.1,2-二氯乙烷致脑水肿过程中自由基的作用研究[J].中国职业医学,2002,29(4):2-6.
[9]Wang G,Yuan Y,Zhang J,et al.Roles of aquaporins and matrix metalloproteinases in mouse brain edema formation induced by subacute exposure to 1,2-dichloroethane[J].Neurotoxicol Teratol,2014,44:105-112.
[10]Zhou X,Cao Y,Leuze C,et al.Early Non-invasive detection of acute1,2-dichloroethane-induced toxic encephalopathy in rats[J].In Vivo,2016,30(6):787-793.
[11]张卫清,孟学莲.1,2-二氯乙烷中毒性脑病的临床及影像学特点分析[J].空军医学杂志,2016,32(6):389-391.
[12]Zhan F,Zheng W,Liu L,et al.Diagnosis and prognosis evaluation of1,2-dichloroethane encephalopathy-magnetic resonance imaging combined with diffusion tensor imaging and magnetic resonance spectroscopy study[J].Neurol India,2011,59(1):108-110.
[13]Xiaoliang Zhou,Wenbin Zhou,Jinxia Zhou,et al.1,2-Dichloroethane-induced toxic leukoencephalopathy with a brain biopsy[J].Neurol Sci,2015,36:817-819.
[14]王秋莎.高压氧综合治疗二氯乙烷中毒性脑病3例[J].中华航海医学与高气压医学杂志,2005,12(3):192.