基于颅脑CT与MRI多模图像融合的3D打印模型制作及应用研究
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摘要
目的研究基于颅脑CT与MRI图像融合的3D打印技术,制作颅脑三维虚拟模型及实体模型,探讨其在临床工作中的意义。方法利用1例小脑幕脑膜瘤患者颅脑CTA、MRI扫描所得的DICOM数据,CT图像分割重建颅骨、血管、头皮模型,MRI图像分割重建脑组织、肿瘤、脑室系统、头皮模型,以头皮模型为基准进行配准融合,完成复合三维虚拟模型的构建,优化处理后经3D打印技术制作实体模型,并邀请15名神经外科医师对模型进行独立评分。结果制作出高逼真度等比例的颅脑实体模型,问卷调查所有问题的平均分均>4分。结论利用颅脑CT与MRI图像融合及3D打印技术制作的三维虚拟模型及其实体模型,对神经外科医师的疾病认识与手术应用、医患沟通、临床培训等方面有重要意义。
Objective To study the 3D virtual model and the 3D-printed model of the brain and to discuss the application value using the new 3D printing technology based on the multi-mode fusion of brain CT and MRI images.Methods DICOM Data from CTA,MRI scans of 1 patients with cerebellar meningioma,use scalp as a benchmark for registration to build 3D composite virtual model(segmentation and reconstruction of skull,blood vessels,and scalp from CT image,reconstruction and segmentation of scalp,brain tissue,and tumor from MRI image),Fifteen neurosurgeons were asked to rate the model independently.ResultsThe anatomical structure of the model showed exactly the same with the intraoperative view,The average score of all the questions in the questionnaire was greater than 4,and the doctors believed that the model could be of great help to the clinical work.Conclusion The 3D virtual model and the 3D-printed model of the brain using the new 3D printing technology based on the multi-mode fusion of brain CT and MRI images is of great value to surgical instruction,doctor-patient communication,clinical training in the neurosurgery field.
Objective To study the 3D virtual model and the 3D-printed model of the brain and to discuss the application value using the new 3D printing technology based on the multi-mode fusion of brain CT and MRI images.Methods DICOM Data from CTA,MRI scans of 1 patients with cerebellar meningioma,use scalp as a benchmark for registration to build 3D composite virtual model(segmentation and reconstruction of skull,blood vessels,and scalp from CT image,reconstruction and segmentation of scalp,brain tissue,and tumor from MRI image),Fifteen neurosurgeons were asked to rate the model independently.ResultsThe anatomical structure of the model showed exactly the same with the intraoperative view,The average score of all the questions in the questionnaire was greater than 4,and the doctors believed that the model could be of great help to the clinical work.Conclusion The 3D virtual model and the 3D-printed model of the brain using the new 3D printing technology based on the multi-mode fusion of brain CT and MRI images is of great value to surgical instruction,doctor-patient communication,clinical training in the neurosurgery field.
引文
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[22]邓滨,欧阳汉斌,黄文华.3D打印在医学领域的应用进展[J].中国医学物理学杂志,2016,33(4):389-392.
[23]方驰华,方兆山,范应方,等.三维可视化、3D打印及3D腹腔镜在肝肿瘤外科诊治中的应用[J].南方医科大学学报,2015,35(5):639-645.
[24]刘红光,杨倩,刘桂锋,等.国内外3D打印快速成型技术的专利情报分析[J].情报杂志,2013,32(6):40-46.
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[26]张学军,唐思熠,肇恒跃,等.3D打印技术研究现状和关键技术[J].材料工程,2016,44(2):122-128.
[2]AHMED A,WATANABE H,AOKI J,et al.Schwan-noma of the extremities:the role of PET in preoperative planning[J].Eur J Nucl Med,2001,28(10):1 541-1 551.
[3]CHETVERIKOV D,STEPANOV D,KRSEK P.Robust Euclidean alignment of 3Dpoint sets:the trimmed iterative closest point algorithm[J].Image Vis Comput,2005,23(3):299-309.
[4]李客楼,李宗安,朱莉娅,等.3D打印技术在医疗领域的应用进展[J].机械设计与制造工,2016,45(9):11-16.
[5]ALALI A B,GRIFFIN M F,CALONGE W M,et al.Evaluating the Use of Cleft Lip and Palate 3D-Printed Models as a Teaching Aid[J].J Surg Educ,2018,75(1):200-208.
[6]NYBERG E L,FARRIS A L,HUNG B P,et al.3DPrinting Technologies for Craniofacial Rehabilitation,Reconstruction,and Regeneration[J].Ann Biomed Eng,2017,45(1):45-57.
[7]GARGIULO P,RNADTTIR,GSLASON M,et al.New Directions in 3D Medical Modeling:3D-Printing Anatomy and Functions in Neurosurgical Planning[J].J Healthc Eng,2017,2017:1439643.doi:10.1155/2017/1439643.
[8]GRAU S,KELLERMANN S,FAUST M,et al.Repair of cerebrospinal fluid leakage using a transfrontal,radial adipofascial flap an individual approach supported by 3dprinting for surgical planning[J].World Neurosurg,2017,110:315-318.doi:10.1016/j.wneu.2017.11.083.
[9]符锋,张赛.3D打印技术在神经外科中的应用[J].中华神经创伤外科电子杂志,2016,2(5):318-320.
[10]钟世镇,方驰华.三维打印技术的临床应用[J].浙江医学,2016,38(18):1 473-1 474.
[11]KURU I,MAIER H,MLLER M,et al.A 3D-printed functioning anatomical human middle ear model[J].Hear Res,2016,340:204-213.
[12]ALYAEV Y G,SIROTA E S,BEZRUKOV E A,et al.Application of 3Dsoft print models of the kidney for treatment of patients with localized cancer of the kidney(apilot study)[J].Urologiia,2017(6):12-19.
[13]DOI K.Diagnostic imaging over the last 50years:research and development in medical imaging science and technology[J].Phys Med Biol,2006,51(13):R5-R27.
[14]DEFERM S,MEYNS B,VLASSELAERS D,et al.3DPrinting in Congenital Cardiology:From Flatland to Spaceland[J].J Clin Imaging Sci,2016,6:8.doi:10.4103/2156-7514.179408.
[15]SCOUTARIS N,ROSS S,DOUROUMIS D.Current Trends on Medical and Pharmaceutical Applications of Inkjet Printing Technology[J].Pharm Res,2016,33(8):1 799-1 816.
[16]SERRA T,CAPELLI C,TOUMPANIARI R,et al.Design and fabrication of 3D-printed anatomically shaped lumbar cage for intervertebral disc(IVD)degeneration treatment[J].Biofabrication,2016,8(3):035001.doi:10.1088/1758-5090/8/3/035001.
[17]王娇,刘洋,张晓玲,等.Mimics软件在医学图像三维重建中的应用[J].医疗卫生装备,2015,36(2):115-118.
[18]VAN BEURDEN M,IJSSELSTEIJN W A,JUOLA J F.Effectiveness of stereoscopic displays in medicine:a review[J].3DRes,2012,3(1):3.
[19]DEFERM S,MEYNS B,VLASSELAERS D,et al.3DPrinting in Congenital Cardiology:From Flatland to Spaceland[J].J Clin Imaging Sci,2016,6:8.doi:10.4103/2156-7514.179408.
[20]刘宇清,吕翱,黄绳跃,等.基于颅脑CTA 3D打印技术在颅内动脉瘤手术治疗中的应用[J].中国微侵袭神经外科杂志,2016,21(6):245-247.
[21]SCHNBERGER M,HOFFSTETTER M.5-Emerging Manufacturing Technologies[M].Elsevier Inc,2016:175-234.
[22]邓滨,欧阳汉斌,黄文华.3D打印在医学领域的应用进展[J].中国医学物理学杂志,2016,33(4):389-392.
[23]方驰华,方兆山,范应方,等.三维可视化、3D打印及3D腹腔镜在肝肿瘤外科诊治中的应用[J].南方医科大学学报,2015,35(5):639-645.
[24]刘红光,杨倩,刘桂锋,等.国内外3D打印快速成型技术的专利情报分析[J].情报杂志,2013,32(6):40-46.
[25]杨新宇.3D打印技术在医学中的应用进展[J].复旦学报(医学版),2016,43(4):490-494.
[26]张学军,唐思熠,肇恒跃,等.3D打印技术研究现状和关键技术[J].材料工程,2016,44(2):122-128.