摘要
富含脯氨酸蛋白酪氨酸激酶(Pyk2)是黏着斑激酶家族中的一员。Pyk2参与包括乳腺癌、肝癌在内的多种肿瘤的发生、浸润及转移,并且与肿瘤的预后密切相关。明确Pyk2在肿瘤发生发展中的作用,能为新的抗癌靶向药物的研发提供理论基础。
Proline-rich protein tyrosine kinase(Pyk2) is a member of the focal adhesion kinase family. Pyk2 is involved in the occurrence, invasion and metastasis of various tumors, including breast and hepatic cancer. It's also closely related to the prognosis of tumors. To clarify the role of Pyk2 in tumorigenesis and development can provide a theoretical basis for the creation of new anti-cancer targeted drugs.
引文
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