浅谈88例多系统萎缩的临床特点
摘要
目的研究多系统萎缩(Multiple system atrophy,MSA)不同亚型患者的临床特点以提高临床诊断的准确性。方法回顾分析2013年1月~2016年1月我院住院及门诊收治的拟诊很可能及可能MSA患者88例的临床资料,包括发病年龄、性别、首发症状、分型、磁共振成像(MR)特征等。结果 88例MSA患者中,男52例,女36例,平均发病年龄(56.28±8.29)岁。41例患者仅以小脑功能障碍为首发症状;16例患者仅以帕金森综合征为首发症状,8例患者仅以自主神经功能障碍为首发症状,其余23例患者的首发表现至少包括上述2种症状组合。70例患者MR可见MSA典型特征。结论 MSA主要累及小脑、锥体外系和自主神经三大系统,临床表现复杂多样,头颅MRI等对该病的诊断很有帮助。
引文
[1]Low PA,Reich SG,et al.Natural history?of?multiple system atrophy?in the USA:a?prospective?[J].cohort study.Lancet Neurol,2015,14(7):710-9.
[2]Gilman S,Wenning GK,et al.Second consensus statement on the diagnosis of multiple system atrophy[J].Neurology,2008,71(9):670-6.
[3]Nicoletti G,Fera F,et al.MR imaging of middle cerebellar peduncle width:differentiation of multiple system atrophy from Parkinson disease[J].Radiology,2006,239(3):825-30.
[4]吴武林,王小宜,等.多系统萎缩磁共振成像特征的研究[J].实用放射学杂志,2008,24(6):724-727.
[5]Seppi K,Schocke MF,et al.How to diagnose MSA early:the role of magnetic resonance imaging[J].Dec,2005,112(12):1625-34.
[2]Gilman S,Wenning GK,et al.Second consensus statement on the diagnosis of multiple system atrophy[J].Neurology,2008,71(9):670-6.
[3]Nicoletti G,Fera F,et al.MR imaging of middle cerebellar peduncle width:differentiation of multiple system atrophy from Parkinson disease[J].Radiology,2006,239(3):825-30.
[4]吴武林,王小宜,等.多系统萎缩磁共振成像特征的研究[J].实用放射学杂志,2008,24(6):724-727.
[5]Seppi K,Schocke MF,et al.How to diagnose MSA early:the role of magnetic resonance imaging[J].Dec,2005,112(12):1625-34.