针刺新吾穴联合鼻鼽汤治疗变应性鼻炎的临床研究
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摘要
目的观察针刺蝶腭神经节联合鼻鼽汤治疗变应性鼻炎的临床疗效。方法患者80例随机分为两组,治疗组给予针刺蝶腭神经节联合鼻鼽汤治疗,对照组给予鼻鼽汤治疗,疗程均为15 d。观察两组治疗前后患者鼻部局部证候积分、中医证候积分、鼻黏膜生活质量量表(RQLQ)评分、IgE、白细胞介素-4(IL-4)、IL-12、IFN-γ水平。结果治疗后患者鼻部局部证候积分、中医证候积分、鼻黏膜生活质量量表(RQLQ)评分、IgE、白细胞介素-4(IL-4)均显著降低,IL-12、IFN-γ均显著增加(P <0.05),治疗组优于对照组(P <0.05)。治疗组总有效率为92.50%,高于对照组的82.50%(P <0.05)。结论针刺蝶腭神经节联合鼻鼽汤治疗变应性鼻炎疗效显著,优于单用鼻鼽汤组。
Objective: To observe the clinical efficacy of acupuncture pterygopalatine combined with Biqiu Decoction on allergic rhinitis. Methods: 80 patients were randomly divided into the control group and the treatment group,40 cases in each. The treatment group was treated with acupuncture pterygopalatine combined with Biqiu Decoction,and the control group was given Biqiu Decoction for 15 days.The patient′ s nasal local syndrome scores,TCM syndrome scores,RQLQ nasal mucosal quality of life scale scores,and the levels of IgE,IL-4,IL-12 and IFN-γ were observed before and after treatment. Results: The patient′ s nasal local syndrome scores,TCM syndrome scores,RQLQ nasal mucosal quality of life scale scores,IgE and IL-4 dropped significantly;IL-12 and IFN-γ increased significantly after treatment(P < 0.05);the treatment group was superior to the control group(P <0.05). The total effective rate was 92.50% in the treatment group,higher than 82.50% in the control group(P <0.05). Conclusion: Acupuncture pterygopalatine combined with Biqiu Decoction is effective on allergic rhinitis,better than single Biqiu Decoction.
Objective: To observe the clinical efficacy of acupuncture pterygopalatine combined with Biqiu Decoction on allergic rhinitis. Methods: 80 patients were randomly divided into the control group and the treatment group,40 cases in each. The treatment group was treated with acupuncture pterygopalatine combined with Biqiu Decoction,and the control group was given Biqiu Decoction for 15 days.The patient′ s nasal local syndrome scores,TCM syndrome scores,RQLQ nasal mucosal quality of life scale scores,and the levels of IgE,IL-4,IL-12 and IFN-γ were observed before and after treatment. Results: The patient′ s nasal local syndrome scores,TCM syndrome scores,RQLQ nasal mucosal quality of life scale scores,IgE and IL-4 dropped significantly;IL-12 and IFN-γ increased significantly after treatment(P < 0.05);the treatment group was superior to the control group(P <0.05). The total effective rate was 92.50% in the treatment group,higher than 82.50% in the control group(P <0.05). Conclusion: Acupuncture pterygopalatine combined with Biqiu Decoction is effective on allergic rhinitis,better than single Biqiu Decoction.
引文
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[19]陈陆泉,王奎吉,谭翊,等.针刺蝶腭神经节治疗中重度变应性鼻炎[J].国际中医中药杂志,2015,38(3):209-212.
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[21]王敏.过敏性鼻炎及过敏原免疫治疗机制的研究进展[J].中国免疫学杂志,2010,26(12):1137-1140.
[2]邵阳阳.参芪鼻炎颗粒治疗变应性鼻炎的药效学评价及机制研究[D].北京:北京协和医学院,2017.
[3]郭霞,杨嘉心,陈跃来.针灸治疗变应性鼻炎的临床研究进展[J].中国民间疗法,2012,20(11):79-80.
[4]高小平,周宇,冯宁宇,等.鼻用糖皮质激素结合鼻腔冲洗治疗变应性鼻炎的疗效观察[J].临床耳鼻咽喉头颈外科杂志,2016,30(9):702-706.
[5]寿崟,张必萌,刘鹏,等.针灸治疗变应性鼻炎的研究进展[J].中医药导报,2017,24(22):106-109.
[6]田勇全,韩东一,迟放鲁,等.耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2013:60-62.
[7]中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2015年,天津)[J].中华耳鼻咽喉头颈外科杂志,2016,51(1):6-24.
[8]熊大经,刘蓬.中医耳鼻咽喉科学[M].北京:中国中医药出版社,2012:184-186.
[9]国家中医药管理局.中华人民共和国中医药行业标准·中医病证诊断疗效标准[M].南京:南京大学出版社,1994:126.
[10]周蓝飞,邓琤琤,丁亚南.针刺新吾穴治疗变应性鼻炎的研究进展[J].江西中医药大学学报,2018,31(2):118-121.
[11]吉增宏,丁允中.针刺蝶腭神经节治疗常年性变应性鼻炎(附122例临床分析)[J].中国中西医结合耳鼻咽喉科杂志,1996,4(1):43-43.
[12]王志福.不同穴位针刺蝶腭神经节治疗变应性鼻炎应用解剖研究[D].福州:福建中医学院,2007.
[13]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉科分会.变应性鼻炎的诊治原则和推荐方案[J].中华耳鼻咽喉头颈外科杂志,2005,40(3):166-167.
[14]DIETZ DE LOOS DA,SEGBOER CL,GEVORGYAN A,et al.Disease-specific quality-of-life questionnaires in rh-initis and rhinosinusitis:review and evaluation[J].Curr Allergy Asthma Rep,2013,13(2):162-170.
[15]谢慧.变应性鼻炎的中医治疗[J].山东大学耳鼻喉眼学报,2016,30(4):22-25.
[16]马凤梅,郭裕.玉屏风散应用经验[J].中医杂志,2010,60(s2):106-106.
[17]吴星儒,刘婉舒,欧祖镇,等.变应性鼻炎经淋巴结注射免疫治疗[J].中华临床免疫和变态反应杂志,2018,12(2):194-197.
[18]田进强,严道南,王东方.变应性鼻炎虚寒证研究初探[J].吉林中医药,2004,24(10):57-59.
[19]陈陆泉,王奎吉,谭翊,等.针刺蝶腭神经节治疗中重度变应性鼻炎[J].国际中医中药杂志,2015,38(3):209-212.
[20]Li Yong,Ruan Gui Ying,Chu Hong Juan,et al.The impact of Yishen Shengyang Fang on immune function and the quality of life for children with asthma complicated allergic rhinitis[J].China Mod Doc,2014,52(32):37-39,42.
[21]王敏.过敏性鼻炎及过敏原免疫治疗机制的研究进展[J].中国免疫学杂志,2010,26(12):1137-1140.