压力性溃疡的发病机制及动物模型构建研究进展
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摘要
<正>随着全球老龄化社会的加剧,压力性溃疡的发病率逐年增高。大样本流行病学资料显示,无论是在医疗机构还是在社区,压力性溃疡的发病率和患病率均较高~([1-2])。预计到2050年我国60岁以上老龄人口总数将超过4亿,占比将超过30%~([3,4])。因此可推测未来几十年,中国压力性溃疡的发病率及患病率将会明显增高。压力性溃疡常反复发作,3或4期压力性溃疡难以愈合,这不仅降低了患者的生活质量,并且增加了家
引文
[1]Jiang Q,Li X,Qu X,et al.The incidence,risk factors and characteristics of pressure ulcers in hospitalized patients in China[J].Int J Clin Exp Pathol,2014,7(5):2587-2594.
[2]Berlowitz D.Clinical staging and management of pressure-induced skin and soft tissue injury[EB/OL].[2018].https://so.uptodate.cn/contents/clinical-staging-andmanagement-of-pressure-inducedskin-and-soft-tissue-injury.
[3]郭梦,班悦,孙千惠,等.中国人口老龄化与疾病的经济负担[J].医学与哲学,2015(7):32-34.
[4]World Population Ageing of 2017 Report[EB/OL].http://www.un.org/en/development/desa/population/publications/pdf/ageing/WPA2017_Report.pdf.
[5]陈泽群,郝岱峰,冯光,等.小型猪皮肤压疮模型的建立及其皮肤病理分析[J].中华损伤与修复杂志:电子版,2016,(6):422-427.
[6]Tsuji S,Ichioka S,Sekiya N,et al.Analysis of ischemiareperfusion injury in a microcirculatory model of pressure ulcers[J].Wound Repair Regen,2005,13(2):209-215.
[7]Peirce S M,Skalak T C,Rodeheaver G T.Ischemia-reperfusion injury in chronic pressure ulcer formation:a skin model in the rat[J].Wound Repair Regen,2000,8(1):68-76.
[8]Wassermann E,van Griensven M,Gstaltner K,et al.A chronic pressure ulcer model in the nude mouse[J].Wound Repair Regen,2009,17(4):480-484.
[9]Stadler I,Zhang R Y,Oskoui P,et al.Development of a simple,noninvasive,clinically relevant model of pressure ulcers in the mouse[J].J Invest Surg,2004,17(4):221-227.
[10]Niitsuma J,Yano H,Togawa T.Experimental study of decubitus ulcer formation in the rabbit ear lobe[J].J Rehabil Res Dev,2003,40(1):67-73.
[11]Thomas D R.Does pressure cause pressure ulcers?An inquiry into the etiology of pressure ulcers[J].J Am Med Dir Assoc,2010,11(6):397-405.
[12]Defloor T.The risk of pressure sores:a conceptual scheme[J].JClin Nurs,1999,8(2):206-216.
[13]Blaisdell F W.The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome:a review[J].Cardiovasc Surg,2002,10(6):620-630.
[14]Nola G T,Vistnes L M.Differential response of skin and muscle in the experimental production of pressure sores[J].Plast Reconstr Surg,1980,66(5):728-733.
[15]柴家科郝岱峰.压疮诊疗新进展与实践[M].北京:人民军医出版社,2013.
[16]Ceelen K K.Aetiology of pressure ulcers:A literature review[J].Technische Universiteit Eindhoven,2003:5-11.
[17]Salcido R,Popescu A,Ahn C.Animal models in pressure ulcer research[J].J Spinal Cord Med,2007,30(2):107-116.
[18]牛波,王切,刘风藏,等.过氧化物酶Ⅰ、过氧化氢酶、超氧化物歧化酶在大鼠肝缺血再灌注损伤小肠内的表达变化[J].解剖学杂志,2017,40(6):651-655.
[19]Granger D N,Korthuis R J.Physiologic mechanisms of postischemic tissue injury[J].Annu Rev Physiol,1995,57:311-332.
[20]Uchiyama A,Yamada K,Perera B,et al.Topical betamethasone butyrate propionate exacerbates pressure ulcers after cutaneous ischemia-reperfusion injury[J].Exp Dermatol,2016,25(9):678-683.
[21]Lambeth J D,Neish A S.Nox enzymes and new thinking on reactive oxygen:a double-edged sword revisited[J].Annu Rev Pathol,2014,9:119-145.
[22]吕建国,孙燕玲.大鼠全脑缺血再灌注后海马CA1区细胞凋亡及银杏叶提取物的保护作用[J].解剖学杂志,2018,41(4):395-399.
[23]高赛红,张小良,杨迎春,等.SB203580对脑缺血再灌注损伤后基质金属蛋白酶9表达的影响[J].解剖学杂志,2018,41(1):45-48,66.
[24]Grisotto P C,Dos S A,Coutinho-Netto J,et al.Indicators of oxidative injury and alterations of the cell membrane in the skeletal muscle of rats submitted to ischemia and reperfusion[J].J Surg Res,2000,92(1):1-6.
[25]Uchiyama A,Yamada K,Perera B,et al.Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury[J].J Invest Dermatol,2015,135(4):1157-1165.
[26]Uchiyama A,Yamada K,Perera B,et al.Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury[J].Sci Rep,2015,5:9072.
[27]Eltzschig H K,Thompson L F,Karhausen J,et al.Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation:coordination by extracellular nucleotide metabolism[J].Blood,2004,104(13):3986-3992.
[28]Luscinsk as FW,Ma S,Nusrat A,et al.Leukocyte transendothelial migration:a junctional affair[J].Semin Immunol,2002,14(2):105-113.
[29]王雪玲.动物压疮模型及压疮形成的分子机制研究进展[J].护理学杂志,2011,(7):90-92.
[30]Nguyen P K,Smith A L,Reynolds K J.A literature review of different pressure ulcer models from 1942-2005 and the development of an ideal animal model[J].Australas Phys Eng Sci Med,2008,31(3):223-225.
[31]2014 Prevention and Treatment of Pressure Ulcers:Clinical Practice Guideline[R].Washington,DC:National Pressure Ulcer Advisory Panel,European Pressure Ulcer Advisory Panel and Pan Pacific Pressure Injury Alliance,2015.
[32]褚万立,郝岱峰.美国国家压疮咨询委员会2016年压力性损伤的定义和分期解读[J].中华损伤与修复杂志:电子版,2018,(1):64-68.
[33]The National Pressure Ulcer Advisory Panel 2016 Staging Consensus Conference,Rosemont(Chicago),2016[C].
[34]Yoshimura M,Nakagami G,Iizaka S,et al.Microclimate is an independent risk factor for the development of intraoperatively acquired pressure ulcers in the park-bench position:a prospective observational study[J].Wound Repair Regen,2015,23(6):939-947.
[35]Gefen A.How do microclimate factors affect the risk for superficial pressure ulcers:a mathematical modeling study[J].J Tissue Viability,2011,20(3):81-88.
[36]秦川,魏泓.实验动物学[M].2版.北京:人民卫生出版社,2015.
[2]Berlowitz D.Clinical staging and management of pressure-induced skin and soft tissue injury[EB/OL].[2018].https://so.uptodate.cn/contents/clinical-staging-andmanagement-of-pressure-inducedskin-and-soft-tissue-injury.
[3]郭梦,班悦,孙千惠,等.中国人口老龄化与疾病的经济负担[J].医学与哲学,2015(7):32-34.
[4]World Population Ageing of 2017 Report[EB/OL].http://www.un.org/en/development/desa/population/publications/pdf/ageing/WPA2017_Report.pdf.
[5]陈泽群,郝岱峰,冯光,等.小型猪皮肤压疮模型的建立及其皮肤病理分析[J].中华损伤与修复杂志:电子版,2016,(6):422-427.
[6]Tsuji S,Ichioka S,Sekiya N,et al.Analysis of ischemiareperfusion injury in a microcirculatory model of pressure ulcers[J].Wound Repair Regen,2005,13(2):209-215.
[7]Peirce S M,Skalak T C,Rodeheaver G T.Ischemia-reperfusion injury in chronic pressure ulcer formation:a skin model in the rat[J].Wound Repair Regen,2000,8(1):68-76.
[8]Wassermann E,van Griensven M,Gstaltner K,et al.A chronic pressure ulcer model in the nude mouse[J].Wound Repair Regen,2009,17(4):480-484.
[9]Stadler I,Zhang R Y,Oskoui P,et al.Development of a simple,noninvasive,clinically relevant model of pressure ulcers in the mouse[J].J Invest Surg,2004,17(4):221-227.
[10]Niitsuma J,Yano H,Togawa T.Experimental study of decubitus ulcer formation in the rabbit ear lobe[J].J Rehabil Res Dev,2003,40(1):67-73.
[11]Thomas D R.Does pressure cause pressure ulcers?An inquiry into the etiology of pressure ulcers[J].J Am Med Dir Assoc,2010,11(6):397-405.
[12]Defloor T.The risk of pressure sores:a conceptual scheme[J].JClin Nurs,1999,8(2):206-216.
[13]Blaisdell F W.The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome:a review[J].Cardiovasc Surg,2002,10(6):620-630.
[14]Nola G T,Vistnes L M.Differential response of skin and muscle in the experimental production of pressure sores[J].Plast Reconstr Surg,1980,66(5):728-733.
[15]柴家科郝岱峰.压疮诊疗新进展与实践[M].北京:人民军医出版社,2013.
[16]Ceelen K K.Aetiology of pressure ulcers:A literature review[J].Technische Universiteit Eindhoven,2003:5-11.
[17]Salcido R,Popescu A,Ahn C.Animal models in pressure ulcer research[J].J Spinal Cord Med,2007,30(2):107-116.
[18]牛波,王切,刘风藏,等.过氧化物酶Ⅰ、过氧化氢酶、超氧化物歧化酶在大鼠肝缺血再灌注损伤小肠内的表达变化[J].解剖学杂志,2017,40(6):651-655.
[19]Granger D N,Korthuis R J.Physiologic mechanisms of postischemic tissue injury[J].Annu Rev Physiol,1995,57:311-332.
[20]Uchiyama A,Yamada K,Perera B,et al.Topical betamethasone butyrate propionate exacerbates pressure ulcers after cutaneous ischemia-reperfusion injury[J].Exp Dermatol,2016,25(9):678-683.
[21]Lambeth J D,Neish A S.Nox enzymes and new thinking on reactive oxygen:a double-edged sword revisited[J].Annu Rev Pathol,2014,9:119-145.
[22]吕建国,孙燕玲.大鼠全脑缺血再灌注后海马CA1区细胞凋亡及银杏叶提取物的保护作用[J].解剖学杂志,2018,41(4):395-399.
[23]高赛红,张小良,杨迎春,等.SB203580对脑缺血再灌注损伤后基质金属蛋白酶9表达的影响[J].解剖学杂志,2018,41(1):45-48,66.
[24]Grisotto P C,Dos S A,Coutinho-Netto J,et al.Indicators of oxidative injury and alterations of the cell membrane in the skeletal muscle of rats submitted to ischemia and reperfusion[J].J Surg Res,2000,92(1):1-6.
[25]Uchiyama A,Yamada K,Perera B,et al.Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury[J].J Invest Dermatol,2015,135(4):1157-1165.
[26]Uchiyama A,Yamada K,Perera B,et al.Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury[J].Sci Rep,2015,5:9072.
[27]Eltzschig H K,Thompson L F,Karhausen J,et al.Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation:coordination by extracellular nucleotide metabolism[J].Blood,2004,104(13):3986-3992.
[28]Luscinsk as FW,Ma S,Nusrat A,et al.Leukocyte transendothelial migration:a junctional affair[J].Semin Immunol,2002,14(2):105-113.
[29]王雪玲.动物压疮模型及压疮形成的分子机制研究进展[J].护理学杂志,2011,(7):90-92.
[30]Nguyen P K,Smith A L,Reynolds K J.A literature review of different pressure ulcer models from 1942-2005 and the development of an ideal animal model[J].Australas Phys Eng Sci Med,2008,31(3):223-225.
[31]2014 Prevention and Treatment of Pressure Ulcers:Clinical Practice Guideline[R].Washington,DC:National Pressure Ulcer Advisory Panel,European Pressure Ulcer Advisory Panel and Pan Pacific Pressure Injury Alliance,2015.
[32]褚万立,郝岱峰.美国国家压疮咨询委员会2016年压力性损伤的定义和分期解读[J].中华损伤与修复杂志:电子版,2018,(1):64-68.
[33]The National Pressure Ulcer Advisory Panel 2016 Staging Consensus Conference,Rosemont(Chicago),2016[C].
[34]Yoshimura M,Nakagami G,Iizaka S,et al.Microclimate is an independent risk factor for the development of intraoperatively acquired pressure ulcers in the park-bench position:a prospective observational study[J].Wound Repair Regen,2015,23(6):939-947.
[35]Gefen A.How do microclimate factors affect the risk for superficial pressure ulcers:a mathematical modeling study[J].J Tissue Viability,2011,20(3):81-88.
[36]秦川,魏泓.实验动物学[M].2版.北京:人民卫生出版社,2015.