四极离子阱阱内离子解离技术的研究进展
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摘要
准确高效的离子解离技术对串联质谱分析方法具有非常重要的影响。四极离子阱可以存储离子,实现离子选择存储或逐出并进行多级质谱分析,适合各种解离技术在阱内的实施。由于生物质谱分析等研究工作对分子结构鉴定的需求,研究人员陆续开发了一系列阱内离子解离技术,推动了相关仪器与应用的发展。本文在离子阱几何结构和阱内离子运动规律的基础上,对是否依赖背景气体碰撞的两类阱内离子解离技术进行综述。其中,将依赖于背景气体碰撞的解离技术分为基于共振激发和非共振激发两类,归纳了每种解离技术的实施过程、解离特点及应用,并对各种解离技术存在的问题以及未来的研究方向进行总结。
Accurate and efficient ion dissociation techniques have a very important impact on tandem mass spectrometry. The quadrupole ion traps are capable of storing ions and performing ions selective storage or ejection and multiple mass spectrometer analysis, which make it ideal for implementation of various dissociation within quadrupole ion trap techniques. A series of dissociation within quadrupole ion trap technologies have been developed for the need of molecular structure identification in research work such as mass spectrometry and it promoted the development of related instruments and applications at the same time. In this paper, the ion dissociation within quadrupole ion trap methods were reviewed, which included two categories depending on whether it depended on background gas based on a brief description of the geometric structure of ion trap and the motion law of ions in ion trap, among them, the dissociation technology depending on the background gas collision could be divided into two categories of resonance excitation and non-resonance excitation. This paper generalizes the implementation process, dissociation characteristics and applications of each dissociation technology, and summarizes the problems of various dissociation technologies and future research directions.
Accurate and efficient ion dissociation techniques have a very important impact on tandem mass spectrometry. The quadrupole ion traps are capable of storing ions and performing ions selective storage or ejection and multiple mass spectrometer analysis, which make it ideal for implementation of various dissociation within quadrupole ion trap techniques. A series of dissociation within quadrupole ion trap technologies have been developed for the need of molecular structure identification in research work such as mass spectrometry and it promoted the development of related instruments and applications at the same time. In this paper, the ion dissociation within quadrupole ion trap methods were reviewed, which included two categories depending on whether it depended on background gas based on a brief description of the geometric structure of ion trap and the motion law of ions in ion trap, among them, the dissociation technology depending on the background gas collision could be divided into two categories of resonance excitation and non-resonance excitation. This paper generalizes the implementation process, dissociation characteristics and applications of each dissociation technology, and summarizes the problems of various dissociation technologies and future research directions.
引文
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[4] MCLUCKEY S A,MENTINOVA M.Ion/neutral,ion/electron,ion/photon,and ion/ion interactions in tandem mass spectrometry:do we need them all?Are they enough?[J].Journal of the American Society for Mass Spectrometry,2011,22(1):3-12.
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[10] DOUGLAS D J,FRANK A J,MAO D.Linear ion traps in mass spectrometry[J].Mass Spectrometry Reviews,2010,24(1):1-29.
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[15] 徐福兴,党乾坤,丁航宇,黄正旭,汪源源,周振,丁传凡.碰撞气体的种类和压力对离子阱质谱性能的影响[J].分析化学,2017,45(4):587-592.XU Fuxing,DANG Qiankun,DING Hangyu,HUANG Zhengxu,WANG Yuanyuan,ZHOU Zhen,DING Chuanfan.Performance investigation of ion trap with various collision gas and pressures[J].Chinese Journal of Analytical Chemistry,2017,45(4):587-592(in Chinese).
[16] MURRELL J,DESPEYROUX D,LAMMERT S A,STEPHENSON J L,GOERINGER D E.“Fast excitation” CID in a quadrupole ion trap mass spectrometer[J].Journal of the American Society for Mass Spectrometry,2003,14(7):785-789.
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[19] HE M,JIANG Y,WANG X,ZHAO Y,YE S,MA J,FANG X,XU W.Rapid characterization of structure-dependency gas-phase ion/ion reaction via accumulative tandem MS[J].Talanta,2019,195:17-22.
[20] SCHWARTZ J C.High-Q pulsed fragmentation in ion traps[P].United States Patent,0054808A1,2005.
[21] GUO T,GAN C S,ZHANG H,ZHU Y,KON O L,SZE S K.Hybridization of pulsed-Q dissociation and collision-activated dissociation in linear ion trap mass spectrometer for iTRAQ quantitation[J].Journal of Proteome Research,2008,7(11):4 831-4 840.
[22] BANTSCHEFF M,BOESCHE M,EBERHARD D,MATTHIESON T,SWEETMAN G,KUSTER B.Robust and sensitive iTRAQ quantification on an LTQ Orbitrap Mass Spectrometer[J].Molecular & Cellular Proteomics,2008,7(9):1 702-1 713.
[23] MEANY D L,XIE H,THOMPSON L D V,ARRIAGA E A,DR T J G.Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry[J].Proteomics,2007,7(7):1 150-1 163.
[24] WU W W,WANG G,INSEL P A,HSIAO C T,ZOU S,MAUDSLEY S,MARTIN B,SHEN R F.Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD)[J].Journal of the American Society for Mass Spectrometry,2011,22(10):1 753-1 762.
[25] L SSNER C,BLACKSTOCK W,GUNARATNE J.Enhanced performance of pulsed Q collision induced dissociation-based peptide identification on a dual-pressure linear ion trap[J].Journal of the American Society for Mass Spectrometry,2012,23(1):186-189.
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[27] JR C C,GLISH G L,BURINSKY D J.High amplitude short time excitation:a method to form and detect low mass product ions in a quadrupole ion trap mass spectrometer[J].J Am Soc Mass Spectrom,2006,17(1):81-84.
[28] DANG Q,XU F,WANG L,HUANG X,DAI X,FANG X,WANG R,DING C F.Theoretical study of dual-direction dipolar excitation of ions in linear ion traps[J].Journal of the American Society for Mass Spectrometry,2016,27(4):596-606.
[29] DANG Q,XU F,XIE X,XU C,DAI X,FANG X,DING L,DING C F.Enhancement of ion activation and collision-induced dissociation by simultaneous dipolar excitation of ions in x- and y-directions in a linear ion trap[J].Analytical Chemistry,2015,87(11):5 561-5 567.
[30] 徐福兴,丁力,戴新华,方向,丁传凡.数字离子阱质谱仪低质量截止值的改进方法[J].分析化学,2014,42(6):918-923.XU Fuxing,DING Li,DAI Xinhua,FANG Xiang,DING Chuanfan.Improvement of low mass cutoff effect using digital ion trap technology[J].Chinese Journal of Analytical Chemistry,2014,42(6):918-923(in Chinese).
[31] CHEN L,MARSHALL A G.Stored waveform simultaneous mass-selective ejection/excitation for Fourier transform ion cyclotron resonance mass spectrometry[J].International Journal of Mass Spectrometry & Ion Processes,1987,79(1):115-125.
[32] GUAN S.General phase modulation method for stored waveform inverse Fourier transform excitation for Fourier transform ion cyclotron resonance mass spectrometry[J].Journal of Chemical Physics,1989,91(2):775-777.
[33] GUAN S,MARSHALL A G.Stored waveform inverse Fourier transform axial excitation/ejection for quadrupole ion trap mass spectrometry[J].Analytical Chemistry,1993,65(9):1 288-1 294.
[34] JULIAN R K,COOKS R G.Broad-band excitation in the quadrupole ion trap mass spectrometer using shaped pulses created with the inverse Fourier transform[J].Analytical Chemistry,1993,65(14):1 827-1 833.
[35] SONI M H,COOKS R G.Selective injection and isolation of ions in quadrupole ion trap mass spectrometry using notched waveforms created using the inverse fourier transform[J].Analytical Chemistry,1994,66(15):2 488-2 496.
[36] GUAN S,MARSHALL A G.Stored waveform inverse Fourier transform (SWIFT) ion excitation in trapped-ion mass spectometry:theory and applications[J].International Journal of Mass Spectrometry & Ion Processes,1996,s157-158(96):5-37.
[37] LOPEZ L L,TILLER P R,SENKO M W,SCHWARTZ J C.Automated strategies for obtaining standardized collisionally induced dissociation spectra on a benchtop ion trap mass spectrometer[J].Rapid Communications in Mass Spectrometry,1999,13(8):663-668.
[38] SNYDER D T,COOKS R G.Multigenerational broadband collision-induced dissociation of precursor ions in a linear quadrupole ion trap[J].Journal of the American Society for Mass Spectrometry,2016,27(12):1 914-1 921.
[39] SNYDER D T,FEDICK P W,COOKS R G.Multigenerational collision-induced dissociation for characterization of organic compounds[J].Analytical Chemistry,2016,2016(88):9 572-9 581.
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