地黄微型饮片制备工艺
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摘要
目的:建立具有高流动、高煎出特征的地黄微型饮片的制备工艺。方法:采用正交试验的方法,以切制方式、粒径、干燥温度为考察因素,以成品率、流动时间及活性成分煎出率为考察指标,对地黄微型饮片的切制工艺进行优化。结果:地黄药材以纵切加横切的方式,切制成0.3～0.4 mm~3的小丁块,并以80℃烘干,其动性和煎出率优于常规地黄饮片。结论:地黄微型饮片切制工艺合理可行,更适用于饮片自动调剂及煎煮设备。
Objective:To establish the preparation process of Rehmanniae Radix micro slices.Method:The orthogonal design was used to investigate the effects of cutting mode,particle size and drying temperature on the processing technology,the comprehensive score of yield、flow time and decocting rate of effective components in Radix Rehmanniae was served as indexes.Results:The best cutting process of Radix Rehmanniae was as follows:crude drug was cutting in the mode of crosscut combined with length cutting,particle size was 0.3-0.4 mm~3 and drying temperature was 80℃,the liquidity and decocting rate were higher than those of traditional slices.Conclusion:The optimized cutting technology of Radix Rehmanniae is reasonable and feasible.It can provide a reference for the research of micro slices.It is more suitable for automatic dispensing and decocting equipment.
Objective:To establish the preparation process of Rehmanniae Radix micro slices.Method:The orthogonal design was used to investigate the effects of cutting mode,particle size and drying temperature on the processing technology,the comprehensive score of yield、flow time and decocting rate of effective components in Radix Rehmanniae was served as indexes.Results:The best cutting process of Radix Rehmanniae was as follows:crude drug was cutting in the mode of crosscut combined with length cutting,particle size was 0.3-0.4 mm~3 and drying temperature was 80℃,the liquidity and decocting rate were higher than those of traditional slices.Conclusion:The optimized cutting technology of Radix Rehmanniae is reasonable and feasible.It can provide a reference for the research of micro slices.It is more suitable for automatic dispensing and decocting equipment.
引文
[1] 国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2015:124-126.
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[3] 刘彦飞,梁东,罗桓,等.地黄的化学成分研究[J].中草药,2014,45(1):16-22.
[4] 黄桢,朱俏峭,戚进,等.地黄的化学成分研究[J].海峡药学,2016,28(7):34-36.
[5] HUANG Y,JIANG C,HU Y,et al.Immunoenhancement effect of rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell[J].Carbohyd Polym,2013,96(1):516-521.
[6] 王娟娟,张振凌,都盼盼,等.UPLC法测定地黄叶及块根中的梓醇和毛蕊花糖苷[J].中成药,2015,37(9):1981-1984.
[7] 朱振兴,段红福.高效液相色谱法测定地黄中梓醇及毛蕊花糖苷的含量[J].中医学报,2013,28(7):1023-1024.
[8] 陈缤,王丽娜,贾天柱.中药饮片的历史沿革[J].中医杂志,2013,54(8):640-643.
[9] 陈彦琳,杜杰.对《中华人民共和国药典》2010年版中药饮片定义的分析与解读[J].中国现代中药,2011,13(3):3-5.
[10] 吴巧娜,徐玉萍.新型中药饮片的发展[J].河北医药,2017,39(9):1407-1410.
[11] 林桂梅,张天连,贾天柱.枳实、枳壳微型饮片切制工艺优化[J].中成药,2017,39(11):2396-2400.
[12] 邓雯,谢果,杨泽锐,等.中药破壁饮片安全性研究进展及思考[J].中国现代中药,2015,17(12):1340-1344.
[13] 穆桂荣.中药配方颗粒与传统中药饮片的应用分析及对策研究[J].中国现代中药,2016,18(8):1081-1083.
[14] 刘慧.小包装中药饮片存在的问题及改进分析[J].中医临床研究,2018,10(6):138-139.
[15] 周维,胡昌江,戴德荣,等.丹参饮片、标准水煎剂、配方颗粒HPLC特征图谱相关性研究[J].中国现代中药,2016,18(9):1100-1102,1113.
[16] 林俊芝,傅超美,毛茜,等.黄柏饮片与煮散颗粒在不同煎煮时间点盐酸小檗碱含量和干膏收率的比较[J].中国实验方剂学杂志,2012,18(12):41-43.
[17] 舒波,龙阳,李毅.粒度对大黄饮片(药材)有效成分的影响分析[J].医学信息,2015,28(38):18-19.
[18] 金玲.中药饮片切制规格对中药汤剂煎煮质量的影响[J].辽宁中医药大学学报,2018,20(3):28-30.
[2] 马新方.地黄的本草考证[J].药学研究,2010,23(7):1-12.
[3] 刘彦飞,梁东,罗桓,等.地黄的化学成分研究[J].中草药,2014,45(1):16-22.
[4] 黄桢,朱俏峭,戚进,等.地黄的化学成分研究[J].海峡药学,2016,28(7):34-36.
[5] HUANG Y,JIANG C,HU Y,et al.Immunoenhancement effect of rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell[J].Carbohyd Polym,2013,96(1):516-521.
[6] 王娟娟,张振凌,都盼盼,等.UPLC法测定地黄叶及块根中的梓醇和毛蕊花糖苷[J].中成药,2015,37(9):1981-1984.
[7] 朱振兴,段红福.高效液相色谱法测定地黄中梓醇及毛蕊花糖苷的含量[J].中医学报,2013,28(7):1023-1024.
[8] 陈缤,王丽娜,贾天柱.中药饮片的历史沿革[J].中医杂志,2013,54(8):640-643.
[9] 陈彦琳,杜杰.对《中华人民共和国药典》2010年版中药饮片定义的分析与解读[J].中国现代中药,2011,13(3):3-5.
[10] 吴巧娜,徐玉萍.新型中药饮片的发展[J].河北医药,2017,39(9):1407-1410.
[11] 林桂梅,张天连,贾天柱.枳实、枳壳微型饮片切制工艺优化[J].中成药,2017,39(11):2396-2400.
[12] 邓雯,谢果,杨泽锐,等.中药破壁饮片安全性研究进展及思考[J].中国现代中药,2015,17(12):1340-1344.
[13] 穆桂荣.中药配方颗粒与传统中药饮片的应用分析及对策研究[J].中国现代中药,2016,18(8):1081-1083.
[14] 刘慧.小包装中药饮片存在的问题及改进分析[J].中医临床研究,2018,10(6):138-139.
[15] 周维,胡昌江,戴德荣,等.丹参饮片、标准水煎剂、配方颗粒HPLC特征图谱相关性研究[J].中国现代中药,2016,18(9):1100-1102,1113.
[16] 林俊芝,傅超美,毛茜,等.黄柏饮片与煮散颗粒在不同煎煮时间点盐酸小檗碱含量和干膏收率的比较[J].中国实验方剂学杂志,2012,18(12):41-43.
[17] 舒波,龙阳,李毅.粒度对大黄饮片(药材)有效成分的影响分析[J].医学信息,2015,28(38):18-19.
[18] 金玲.中药饮片切制规格对中药汤剂煎煮质量的影响[J].辽宁中医药大学学报,2018,20(3):28-30.