延胡索产地鲜切加工工艺响应面优化研究
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摘要
目的通过响应面法优化延胡索产地鲜切加工工艺,得到延胡索产地鲜切加工的最佳工艺。方法以切片厚度、热风干燥温度、装载量为考察因素,以总生物碱含量、浸出物含量、干燥效率为考察指标,通过主成分分析法得到各指标的权重系数,计算综合评分,对考察因素进行单因素分析,得到初步优化范围,最后以响应面优化法进行优化,得到最后工艺优化参数。结果确定最佳产地鲜切加工工艺:切片厚度为4 mm,干燥装载量为7 kg/m~2,干燥温度为85℃,干燥总时间为(279.0±1.1)min,综合评分为0.860 6±0.010 0,此时延胡索总生物碱质量分数为(6.274±0.030)mg/g;浸出物质量分数为(17.86±0.22)%;干燥效率为(25.09±0.00)g/(m~2·min)。结论建立的干燥工艺能够较好地保留延胡索中生物碱成分和浸出物,保持较高的干燥效率,在保证较高的质量同时,降低企业能耗,可为延胡索饮片的生产加工提供可靠的理论依据。
Objective To optimize the fresh-cutting process of Corydalis Rhizoma by response surface methodology, and obtain the best technology for fresh-cut processing of Corydalis Rhizoma. Methods The slice thickness, the hot air drying temperature and the loading amount were taken as the investigation factors. The total alkaloid content, the extract content and the drying efficiency were taken as the indicators. The weight coefficient of each index was obtained by principal component analysis method, and the comprehensive score was calculated. Single factor analysis was performed on the investigation factors to obtain the initial optimization range, and the response surface optimization method was used to optimize the final process optimization parameters.Results The best production conditions for fresh-cut processing were determined as slice thickness of 4 mm, dry load of 7 kg/m~2,drying temperature of 85 ℃, total drying time of(279.0 ± 1.1) min, and comprehensive score of(0.860 6 ± 0.010 0). At this time, the total alkaloid content of Corydalis Rhizoma was(6.274 ± 0.030) mg/g, the content of the leachate was(17.86 ± 0.22)%, and the drying efficiency was(25.09 ± 0.00) g/(m~2·min). Conclusion The established drying process can better preserve the content of alkaloids and extracts in Corydalis Rhizoma, maintain high drying efficiency, ensure high quality and reduce energy consumption of enterprises, and provide a reliable theoretical basis for the production and processing of Corydalis Rhizoma pieces.
Objective To optimize the fresh-cutting process of Corydalis Rhizoma by response surface methodology, and obtain the best technology for fresh-cut processing of Corydalis Rhizoma. Methods The slice thickness, the hot air drying temperature and the loading amount were taken as the investigation factors. The total alkaloid content, the extract content and the drying efficiency were taken as the indicators. The weight coefficient of each index was obtained by principal component analysis method, and the comprehensive score was calculated. Single factor analysis was performed on the investigation factors to obtain the initial optimization range, and the response surface optimization method was used to optimize the final process optimization parameters.Results The best production conditions for fresh-cut processing were determined as slice thickness of 4 mm, dry load of 7 kg/m~2,drying temperature of 85 ℃, total drying time of(279.0 ± 1.1) min, and comprehensive score of(0.860 6 ± 0.010 0). At this time, the total alkaloid content of Corydalis Rhizoma was(6.274 ± 0.030) mg/g, the content of the leachate was(17.86 ± 0.22)%, and the drying efficiency was(25.09 ± 0.00) g/(m~2·min). Conclusion The established drying process can better preserve the content of alkaloids and extracts in Corydalis Rhizoma, maintain high drying efficiency, ensure high quality and reduce energy consumption of enterprises, and provide a reliable theoretical basis for the production and processing of Corydalis Rhizoma pieces.
引文
[1]中国药典[S].一部.2015.
[2]鲁春梅,张春森,姜立勇.延胡索化学成分及药理作用研究进展[J].中国现代药物应用,2011,5(15):126-127.
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[5]王磊,王媛,李爱主,等.基于靶细胞萃取的延胡索药效成分的筛选和含量测定[J].药物评价研究,2016,39(6):990-994.
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[8]张铁军,许浚,韩彦琪,等.中药质量标志物(Q-marker)研究:延胡索质量评价及质量标准研究[J].中草药,2016,47(9):1458-1467.
[9]段金廒,宿树兰,吕洁丽,等.药材产地加工传统经验与现代科学认识[J].中国中药杂志,2009,34(24):3151-3157.
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[11]胡锦祥,吴瑾瑾,王群星,等.大孔吸附树脂纯化延胡索总生物碱工艺研究[J].中草药,2018,49(18):4302-4310.
[12]郑军献,徐雁,洪春霞,等.延胡索不同加工工艺的研究[J].浙江中医杂志,2012,47(5):379-380.
[13]任江剑,徐建中,俞旭平.不同采收期和不同加工方法对延胡索药材的影响[J].中药材,2009,32(7):1026-1028.
[14]李静慧.延胡索药材质量控制的关键技术研究[D].杭州:浙江大学,2012.
[15]Li R,Niu Y B,Dou Z Y.Comparative study for pharmacological action of Corydalis Rhizoma before and after processing[J].Chin Herb Med,2015,7(3):247-254.
[2]鲁春梅,张春森,姜立勇.延胡索化学成分及药理作用研究进展[J].中国现代药物应用,2011,5(15):126-127.
[3]陈林伟,秦昆明,朱艳汇,等.中药材产地加工的研究现状及展望[J].中国中药杂志,2015,40(4):602-606.
[4]杨俊杰,李林,季德,等.中药材产地加工与炮制一体化的历史沿革与现代研究探讨[J].中草药,2016,47(15):2751-2757.
[5]王磊,王媛,李爱主,等.基于靶细胞萃取的延胡索药效成分的筛选和含量测定[J].药物评价研究,2016,39(6):990-994.
[6]张丽,丁安伟.中药材产地加工-饮片炮制一体化研究思路探讨[J].江苏中医药,2016,48(9):70-71.
[7]陈强,陆兔林,毛春芹,等.中药蒸制的研究进展[J].中国药房,2009,20(36):2871-2873.
[8]张铁军,许浚,韩彦琪,等.中药质量标志物(Q-marker)研究:延胡索质量评价及质量标准研究[J].中草药,2016,47(9):1458-1467.
[9]段金廒,宿树兰,吕洁丽,等.药材产地加工传统经验与现代科学认识[J].中国中药杂志,2009,34(24):3151-3157.
[10]孙乙铭,俞旭平,徐建中,等.延胡索产地加工的工艺研究[J].中国现代应用药学,2011,28(10):923-926.
[11]胡锦祥,吴瑾瑾,王群星,等.大孔吸附树脂纯化延胡索总生物碱工艺研究[J].中草药,2018,49(18):4302-4310.
[12]郑军献,徐雁,洪春霞,等.延胡索不同加工工艺的研究[J].浙江中医杂志,2012,47(5):379-380.
[13]任江剑,徐建中,俞旭平.不同采收期和不同加工方法对延胡索药材的影响[J].中药材,2009,32(7):1026-1028.
[14]李静慧.延胡索药材质量控制的关键技术研究[D].杭州:浙江大学,2012.
[15]Li R,Niu Y B,Dou Z Y.Comparative study for pharmacological action of Corydalis Rhizoma before and after processing[J].Chin Herb Med,2015,7(3):247-254.