头皮冷却疗法预防乳腺癌化疗病人脱发效果及其影响因素研究
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摘要
[目的]探讨头皮冷却疗法对化疗诱导脱发的预防效果及影响因素。[方法]选取2014年6月—2015年6月肿瘤科收治的182例乳腺癌化疗同时进行头皮冷却治疗的病人,观察头皮冷却治疗的效果,分析影响头皮冷却疗效的相关因素。[结果]182例病人中有111例病人(60.9%)头皮冷却治疗效果良好,化疗药物的种类及剂量、病人年龄、经期状态、系统性疾病以及相应使用的药物、抑郁均对头皮冷却的疗效有影响。[结论]化疗过程中应用头皮冷却疗法对化疗诱导的脱发进行干预,有助于改善化疗病人的生活质量和心理体验。
引文
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[2]Hesketh PJ,Batchelor D,Golant M,et al.Chemotherapy-induced alopecia:psychosocial impact and therapeutic approaches[J].Support Care Cancer,2004,12:543-549.
[3]Breed W,van den Hurk CJ,Peerbooms M.Presentation,impact and prevention of chemotherapy induced hair loss:scalp cooling potentials and limitations[J].Dermatology,2011,6:109-125.
[4]Trueb RM.Chemotherapy-induced hair loss[J].Skin Therapy Lett,2010,15:5-7.
[5]Grevelman EG,Breed WP.Prevention of chemotherapy-induced hair loss by scalp cooling[J].Ann Oncol,2005,16:352-358.
[6]Komen MM,Smorenburg CH,van den Hurk CJ,et al.Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia[J].Oncologist,2013,18(7):885-891.
[7]Hurria A,Lichtman SM.Clinical pharmacology of cancer therapies in older adults[J].Br J Cancer,2008,98:517-522.
[8]Holowatz LA,Kenney WL.Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans[J].J Appl Physiol,2010,109:1538-1544.
[9]Robbins C,Mirmirani P,Messenger AG,et al.What women want quantifying the perception of hair amount:an analysis of hair diameter and density changes with age in Caucasian women[J].Br J Dermatol,2012,167:324-332.
[10]Selleri S,Seltmann H,Gardiboldi S,et al.Doxorubicin-induced alopecia is associated with sebaceous gland degeneration[J].J Invest Dermatol,2006,126:711-720.
[11]Yaar M,Gilchrest BA.Skin aging:postulated mechanisms and consequent changes in structure and function[J].Clin Geriatr Med,2001,17:617-630.
[12]Arias-Santiago S,Gutierrez-Salmeron MT,Castellote-Caballero L,et al.Androgenetic alopecia and cardiovascular risk factors in men and women:a comparative study[J].J Am Acad Dermatol,2010,63:420-429.
[13]Matilainen V,Laakso M,Hirsso P,et al.Hair loss,insulin resistance,and heredity in middle-aged women:a population-based study[J].J Cardiovasc Risk,2003,10:227-231.
[14]Muzzatti B,Mella S,Bomben F.Intensity and prevalence of depressive states in cancer inpatients:a large sample descriptive study[J].Eur J Cancer Care(Engl),2016,1:30.