乳腺癌改良根治术中行胸肌间淋巴结清扫对患者淋巴细胞比值及预后影响
摘要
目的探讨乳腺癌改良根治术中行胸肌间淋巴结(IPNs)清扫对患者的淋巴细胞比值(NLR)及预后的影响。方法选取解放军923医院自2012年3月至2014年3月收治的70例行乳腺癌改良根治术的患者为研究对象。根据是否行IPNs清扫将所有患者分为A、B两组,每组各35例。比较两组患者的术后NLR、并发症发生情况及预后情况。结果两组患者术后的并发症发生率比较,差异无统计学意义(P>0.05)。B组患者术后NLR为(2.2±1.4),低于A组的(3.5±1.6),但差异有统计学意义(P<0.05)。B组患者3年总存活率为97.1%(34/35),高于A组的94.3%(33/35),但差异无统计学意义(P>0.05)。B组患者3年局部复发率为2.9%(1/35),低于A组的17.1%(6/35),两组比较,差异有统计学意义(P<0.05)。两组患者术后6个月生理状况、情感状况、功能状况及生活质量总和评分比较,差异均无统计学意义(P>0.05)。结论乳腺癌改良根治术中行IPNs清扫在不增加术后并发症的前提下可有效改善患者的预后。
引文
[1] Horn J,Opdahl S,Engstr?m MJ,et al.Reproductive history and the risk of molecular breast cancer subtypes in a prospective study of Norwegian women[J].Cancer Causes Control,2014,25(7):881-889.
[2] Keyzer-Dekker CM,de Vries J,Mertens MC,et al.The impact of diagnosis and trait anxiety on psychological distress in women with early stage breast cancer:a prospective study[J].Br J Health Psychol,2014,19(4):783-794.
[3] 王勇攀,王全,顾海青.浸润性乳腺癌经胸肌间入路锁骨下淋巴结清扫术41例体会[J].实用肿瘤杂志,2013,28(3):325-326.
[4] 柯章明,孙圣荣.乳腺癌患者胸肌间淋巴结转移的相关因素[J].实用癌症杂志,2015,30(11):1681-1683.
[5] 刘兵雄,孙圣荣.改良根除术联合自体植皮术在乳腺癌手术中的应用价值[J].实用癌症杂志,2016,2:280-282.
[6] Agrawal S,Goel AK,Lal P.Participation in decision making regarding type of surgery and treatment-related satisfaction in North Indian women with early breast cancer[J].J Cancer Res Ther,2012,8(2):222-225.
[7] Sharma S,Moros EG,Boerma M,et al.A novel technique for image-guided local heart irradiation in the rat[J].Technol Cancer Res Treat,2014,13(6):593-603.
[8] 范小庆,熊秋云,雷秋模.乳腺癌胸肌间淋巴结清扫的临床意义[J].实用癌症杂志,2013,28(3):260-262.
[9] 柯章明,孙圣荣.乳腺癌患者胸肌间淋巴结转移的相关因素[J].实用癌症杂志,2015,30(11):1681-1683.
[10] 周际昌.实用肿瘤内科学[M].北京:人民卫生出版社,1999.
[11] Qi Q,Geng Y,Sun M,et al.Clinical implications of systemic inflammatory response markers as independent prognostic factors for advanced pancreatic cancer[J].Pancreatology,2015,15(2):145-150.
[12] Jiang N,Deng JY,Liu Y,et al.The role of preoperative neutrophil-lymphocyte and platelet-lymphocyte ratio in patients after radical resection for gastric cancer[J].Biomarkers,2014,19(6):444-451.
[13] 马晋平,王智,林建伟,等.中性粒细胞/淋巴细胞比值在胃癌预后评估中的应用[J].中华胃肠外科杂志,2011,14(12):944-947.
[2] Keyzer-Dekker CM,de Vries J,Mertens MC,et al.The impact of diagnosis and trait anxiety on psychological distress in women with early stage breast cancer:a prospective study[J].Br J Health Psychol,2014,19(4):783-794.
[3] 王勇攀,王全,顾海青.浸润性乳腺癌经胸肌间入路锁骨下淋巴结清扫术41例体会[J].实用肿瘤杂志,2013,28(3):325-326.
[4] 柯章明,孙圣荣.乳腺癌患者胸肌间淋巴结转移的相关因素[J].实用癌症杂志,2015,30(11):1681-1683.
[5] 刘兵雄,孙圣荣.改良根除术联合自体植皮术在乳腺癌手术中的应用价值[J].实用癌症杂志,2016,2:280-282.
[6] Agrawal S,Goel AK,Lal P.Participation in decision making regarding type of surgery and treatment-related satisfaction in North Indian women with early breast cancer[J].J Cancer Res Ther,2012,8(2):222-225.
[7] Sharma S,Moros EG,Boerma M,et al.A novel technique for image-guided local heart irradiation in the rat[J].Technol Cancer Res Treat,2014,13(6):593-603.
[8] 范小庆,熊秋云,雷秋模.乳腺癌胸肌间淋巴结清扫的临床意义[J].实用癌症杂志,2013,28(3):260-262.
[9] 柯章明,孙圣荣.乳腺癌患者胸肌间淋巴结转移的相关因素[J].实用癌症杂志,2015,30(11):1681-1683.
[10] 周际昌.实用肿瘤内科学[M].北京:人民卫生出版社,1999.
[11] Qi Q,Geng Y,Sun M,et al.Clinical implications of systemic inflammatory response markers as independent prognostic factors for advanced pancreatic cancer[J].Pancreatology,2015,15(2):145-150.
[12] Jiang N,Deng JY,Liu Y,et al.The role of preoperative neutrophil-lymphocyte and platelet-lymphocyte ratio in patients after radical resection for gastric cancer[J].Biomarkers,2014,19(6):444-451.
[13] 马晋平,王智,林建伟,等.中性粒细胞/淋巴细胞比值在胃癌预后评估中的应用[J].中华胃肠外科杂志,2011,14(12):944-947.