妊娠期糖尿病孕妇糖化血红蛋白的表达特征分析
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摘要
目的分析妊娠期糖尿病孕妇糖化血红蛋白表达水平的变化特征。方法将2016年4月～2017年3月在我院确诊为妊娠期糖尿病的46例孕妇作为研究组,将同期接受产前检查的52例健康孕妇作为对照组,检测两组孕妇糖化血红蛋白水平,进行对比分析。采用WHITE分类法对研究组孕妇进行疾病分期,其中疾病分期为A1级的孕妇共28例,疾病分期为A2级的孕妇共18例,比较不同疾病分期孕妇的糖化血红蛋白水平,对两组孕妇进行随访,比较两组孕妇的妊娠结局。结果研究组孕妇的糖化血红蛋白水平为(7.08±0.59)%,高于对照组孕妇的(4.42±0.61)%(P<0.05);疾病分期为A1期孕妇的糖化血红蛋白水平为(5.93±0.48)%,低于疾病分期为A2期孕妇的(8.25±0.51)%(P<0.05);研究组孕妇的不良妊娠结局总发生率为17.39%,高于对照组孕妇的3.85%(P<0.05)。结论妊娠期糖尿病孕妇的糖化血红蛋白水平明显高于健康孕妇,且病情越严重,血红蛋白表达水平越高,可对孕妇妊娠结局产生不良影响。
Objective To analyze the changes characteristics of glycosylated hemoglobin levels in pregnant women with gestational diabetes mellitus(DM). Methods Forty-six pregnant women with gestational diabetes mellitus diagnosed in our hospital from April 2016 to March 2017 were selected as the study group, and 52 healthy pregnant women who received antenatal examination at the same time as the control group, the glycosylated hemoglobin levels of the two groups were detected and compared. WHITE classification was used to classify the disease stages of the pregnant women in the study group. There were 28 pregnant women with A1 disease stage and 18 pregnant women with A2 disease stage, the glycosylated hemoglobin levels of pregnant women in different disease stages were compared, and the pregnancy outcomes of the two groups were compared. Results The level of HbA1 c in the study group was(7.08±0.59)%higher than(4.42±0.61)% in the control group(P<0.05). The glycosylated hemoglobin level of pregnant women with stage A1 was(5.93±0.48)%, lower than(8.25±0.51)% of pregnant women with stage A2(P<0.05). The total incidence of adverse pregnancy outcomes was 17.39% in the study group, which was higher than 3.85% in the control group(P<0.05). Conclusion The level of glycosylated hemoglobin in gestational diabetes mellitus pregnant women was significantly higher than that in healthy pregnant women, and the more serious the disease, the higher the level of hemoglobin expression, which could have adverse effects on the pregnancy outcome of pregnant women.
Objective To analyze the changes characteristics of glycosylated hemoglobin levels in pregnant women with gestational diabetes mellitus(DM). Methods Forty-six pregnant women with gestational diabetes mellitus diagnosed in our hospital from April 2016 to March 2017 were selected as the study group, and 52 healthy pregnant women who received antenatal examination at the same time as the control group, the glycosylated hemoglobin levels of the two groups were detected and compared. WHITE classification was used to classify the disease stages of the pregnant women in the study group. There were 28 pregnant women with A1 disease stage and 18 pregnant women with A2 disease stage, the glycosylated hemoglobin levels of pregnant women in different disease stages were compared, and the pregnancy outcomes of the two groups were compared. Results The level of HbA1 c in the study group was(7.08±0.59)%higher than(4.42±0.61)% in the control group(P<0.05). The glycosylated hemoglobin level of pregnant women with stage A1 was(5.93±0.48)%, lower than(8.25±0.51)% of pregnant women with stage A2(P<0.05). The total incidence of adverse pregnancy outcomes was 17.39% in the study group, which was higher than 3.85% in the control group(P<0.05). Conclusion The level of glycosylated hemoglobin in gestational diabetes mellitus pregnant women was significantly higher than that in healthy pregnant women, and the more serious the disease, the higher the level of hemoglobin expression, which could have adverse effects on the pregnancy outcome of pregnant women.
引文
[1]朱晓琴,岳虹霓.糖化血红蛋白水平与妊娠期糖尿病患者并发症及妊娠结局的相关性研究[J].中国妇幼保健,2017,32(14):3173-3175.
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[3]张青川,张林华,王会青,等.妊娠期糖尿病患者血清空腹血糖、餐后2 h血糖、糖化血红蛋白水平变化及其与不良妊娠结局的关系研究[J].实用临床医药杂志,2017,21(24):23-26.
[4]王俊凤,莫洁平,杨志,等.双C疗法治疗高龄孕妇妊娠期糖尿病并妊娠期高血压疾病的可行性分析[J].中国医学创新,2018,15(14):137-140.
[5]王婧,徐琢,谷阳,等.高血压合并妊娠期糖尿病慢性心衰患者糖化血红蛋白与C-反应蛋白、脑钠肽的相关性[J].中国妇幼保健,2017,32(24):6142-6144.
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[7]龚妙添.血清中糖化血红蛋白和白蛋白水平与妊娠期糖尿病患者术后感染风险及医疗费用的关系[J].中国卫生检验杂志,2017,27(22):3289-3291.
[8]丁秀花.不同干预方案对妊娠期糖尿病产妇糖化血红蛋白水平及妊娠结局的影响[J].中国妇幼保健,2017,32(22):5550-5552.
[9]李瑞琼,辜素梅,杨丽红.糖化血红蛋白水平在预测妊娠期糖尿病孕妇生产结局中的价值分析[J].中国计划生育和妇产科,2017,9(10):48-50,54.
[10]马亚娟,杜清丽,杨彩萍.糖化血红蛋白检测在妊娠期糖尿病诊断中的应用价值[J].临床医学研究与实践,2017,2(22):129-130.
[11]王娜,鲁海鸟,周游,等.妊娠期糖尿病孕妇体质指数和糖化血红蛋白水平与围生结局的关系[J].中国妇幼保健,2017,32(15):3418-3420.
[12]翟晓丽,许筠,张军,等.D-二聚体及糖化血红蛋白预测妊娠期糖尿病患者发生胎儿生长受限的价值[J].中国妇幼保健,2017,32(15):3421-3424.
[13]林春晓,李春花,缪士霞,等.妊娠期糖尿病不同糖化血红蛋白水平的围产结局分析[J].实用医学杂志,2015,26(8):1268-1270.
[14]俞琳,许岚,蒋艳敏.孕早期血红蛋白在妊娠期糖尿病发病中的重要性[J].南京医科大学学报(自然科学版),2017,37(7):886-889.
[15]黄晓燕,张高芝,臧循雄.妊娠期糖尿病孕妇血糖、糖化血红蛋白与甲状腺功能的相关性[J].中国妇幼保健,2018,33(4):760-763.
[16]魏青文,颜彬,龚丽娟.糖化血红蛋白、糖化血清蛋白、C反应蛋白联合检测对早期妊娠期糖尿病的诊断价值[J].中国计划生育和妇产科,2018,10(1):54-56.
[2]徐菁.血浆糖化血红蛋白对妊娠期糖尿病发展为2型糖尿病的预测价值[J].广西医科大学学报,2017,34(7):1016-1018.
[3]张青川,张林华,王会青,等.妊娠期糖尿病患者血清空腹血糖、餐后2 h血糖、糖化血红蛋白水平变化及其与不良妊娠结局的关系研究[J].实用临床医药杂志,2017,21(24):23-26.
[4]王俊凤,莫洁平,杨志,等.双C疗法治疗高龄孕妇妊娠期糖尿病并妊娠期高血压疾病的可行性分析[J].中国医学创新,2018,15(14):137-140.
[5]王婧,徐琢,谷阳,等.高血压合并妊娠期糖尿病慢性心衰患者糖化血红蛋白与C-反应蛋白、脑钠肽的相关性[J].中国妇幼保健,2017,32(24):6142-6144.
[6]施雯君.妊娠糖尿病患者糖化血红蛋白监测的临床意义[J].实用临床医药杂志,2014,18(3):111-112.
[7]龚妙添.血清中糖化血红蛋白和白蛋白水平与妊娠期糖尿病患者术后感染风险及医疗费用的关系[J].中国卫生检验杂志,2017,27(22):3289-3291.
[8]丁秀花.不同干预方案对妊娠期糖尿病产妇糖化血红蛋白水平及妊娠结局的影响[J].中国妇幼保健,2017,32(22):5550-5552.
[9]李瑞琼,辜素梅,杨丽红.糖化血红蛋白水平在预测妊娠期糖尿病孕妇生产结局中的价值分析[J].中国计划生育和妇产科,2017,9(10):48-50,54.
[10]马亚娟,杜清丽,杨彩萍.糖化血红蛋白检测在妊娠期糖尿病诊断中的应用价值[J].临床医学研究与实践,2017,2(22):129-130.
[11]王娜,鲁海鸟,周游,等.妊娠期糖尿病孕妇体质指数和糖化血红蛋白水平与围生结局的关系[J].中国妇幼保健,2017,32(15):3418-3420.
[12]翟晓丽,许筠,张军,等.D-二聚体及糖化血红蛋白预测妊娠期糖尿病患者发生胎儿生长受限的价值[J].中国妇幼保健,2017,32(15):3421-3424.
[13]林春晓,李春花,缪士霞,等.妊娠期糖尿病不同糖化血红蛋白水平的围产结局分析[J].实用医学杂志,2015,26(8):1268-1270.
[14]俞琳,许岚,蒋艳敏.孕早期血红蛋白在妊娠期糖尿病发病中的重要性[J].南京医科大学学报(自然科学版),2017,37(7):886-889.
[15]黄晓燕,张高芝,臧循雄.妊娠期糖尿病孕妇血糖、糖化血红蛋白与甲状腺功能的相关性[J].中国妇幼保健,2018,33(4):760-763.
[16]魏青文,颜彬,龚丽娟.糖化血红蛋白、糖化血清蛋白、C反应蛋白联合检测对早期妊娠期糖尿病的诊断价值[J].中国计划生育和妇产科,2018,10(1):54-56.